797results about How to "High pressure" patented technology

A blower for providing a supply of air at positive pressure in the range of approximately 2 cm H2O to 30 cm H2O includes a motor, at least one impeller, and a stationary component. The stationary component includes an inlet and an outlet. The motor, the impeller, the inlet and outlet are co-axial.

Apparatuses for restricting fluid flow through a well conduit comprise a housing having a longitudinal bore and a seat disposed within the bore. The seat has a first position when the apparatus is in the run-in position and a second position when the apparatus is in the set position. The seat comprises an arcuate member comprising a plurality of slits defining a plurality of segment members having a gap there-between. Each of the gaps are variable such that movement of segment members inwardly causes the gaps to be narrowed or closed off completely when a plug element is disposed into the bore and landed on the arcuate member to move the arcuate member from the first position to the second position, causing restriction of fluid flow through the bore and the well conduit.

Systems for treating a bone, e.g. a vertebral body, having an interior volume occupied, at least in part, by cancellous bone provide a first tool, a second tool, and a third tool. The first tool establishes a percutaneous access path to bone. The second tool is sized and configured to be introduced through the percutaneous access path to form a void that occupies less than the interior volume. The third tool places within the void through the percutaneous access path a volume of filling material. Related methods for treating a bone, e.g. a vertebral body, having an interior volume occupied, at least in part, by cancellous bone provide establishing a percutaneous access path to bone. A tool is introduced through the percutaneous access path and manipulated to form a void that occupies less than the interior volume. A volume of filling material is then placed within the void through the percutaneous access path.

The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after innoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.

Apparatuses for restricting fluid flow through a well conduit comprise a housing having a longitudinal bore and a seat disposed within the bore. The seat has a first position when the apparatus is in the run-in position and a second position when the apparatus is in the set position. The seat comprises an arcuate member comprising a plurality of slits defining a plurality of segment members having a gap there-between. Each of the gaps are variable such that movement of segment members inwardly causes the gaps to be narrowed or closed off completely when a plug element is disposed into the bore and landed on the arcuate member to move the arcuate member from the first position to the second position, causing restriction of fluid flow through the bore and the well conduit.

Described herein are nasal respiratory devices, in particular, nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. In some variations, these devices have a threshold pressure for closing during expiration.

A support contour of a cushion, such as a wheelchair cushion, defines relief areas at locations adjacent to skin covering the ischial tuberosities, the greater trochanters and the coccyx and sacrum of a person sitting on the support contour. Support areas of the support contour transfer force into the pelvic area adjacent to skin covering tissue masses on opposite lateral sides of the posterior buttocks and beneath the proximal thighs of the person. Greater clearance is also provided in the perineal area. Risks of pressure ulcers from pressure and shear forces on bony prominences is reduced while providing support at the broader areas without bony prominences in such a manner to encourage postural alignment. The risks of skin breakdown perineal are diminished.

A flexible support structure of a seat cushion, such as a wheelchair cushion, has an upper surface with a support contour having relief areas for establishing relatively less pressure on skin adjacent to bony prominences of a user's pelvis and having a support area for establishing relatively more pressure on skin covering a tissue mass spaced from the bony prominences. A slit is formed in the rear corner of the support structure and an insertion member is inserted into the slit to change a position of the support area to thereby adjust the support contour for better support of the pelvic area. A cover encases the support structure to resist outward deformation of the support structure. The cover has an extension portion that expands the cover at the rear corner to increase a dimension of the cover to encase an increase dimension of the corner caused by the insertion of the insertion member.