The invention discloses a high-power pulse tube refrigerator based on a Stirling refrigerator, which comprises a crank connecting link, a compression piston, an after-stage water cooler, a regenerator, a cold-end heat exchanger and a pulse tube system. A moving part, namely an expansion piston at a cold end of the prior (Phillips) Stirling refrigerator is substituted by the pulse tube system, andthe pulse tube system comprises a pulse tube, a hot-end heat exchanger, an inertance tube and an air reservoir. No moving part exists at a cold end of the high-power pulse tube refrigerator, thereby solving the problems such as machine wear and serious vibration caused by the expansion piston, remarkably improving the reliability of the refrigerator and widening the application range of the refrigerator. The high-power pulse tube refrigerator adopts the annular regenerator with mature technology, reduces the annular flow of gas in the regenerator, effectively solves the problems of nonuniformtemperature and flowing universally existing in the high-power pulse tube refrigerator, and increases the symmetry of radial temperature, thereby reducing the loss of the regenerator in the high-powerpulse tube refrigerator, and improving the efficiency of the refrigerator.