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149results about "Plasma/lacto globulins" patented technology
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Methods and compositions for targeted cleavage and recombination
ActiveUS7888121B2High frequencyInhibitory activityFusion with DNA-binding domainHydrolasesPolynucleotideGenome
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
Owner:SANGAMO BIOSCIENCES INC
Expression vector for animal cell
InactiveUS7422874B2Increased expression efficiency and levelVectorsSugar derivativesGastrin GeneEvolutionary biology
The present invention relates to an expression vector for animal cells. Specifically, the present invention relates to an expression vector, pMS vector, pSG vector and pMSG vector, including the human β-globin 5′ MAR complementary sequence or / and the transcription termination site of the gastrin gene. An expression system using an expression vector of the present invention can successfully produce recombinant proteins in various animals cells and recombinant protein having a unique structure and function.
Owner:MOGAM BIOTECH RES INST +1
Method for improving gene targeting efficiency and method for carrying out in-situ repair on base on beta-globulin gene locus
InactiveCN106244555AShorten the construction experiment cycleHigh miss rateNucleic acid vectorVector-based foreign material introductionGene targetsGene Modification
The invention provides a method for improving the gene targeting efficiency and a method for carrying out in-situ repair on the base on a beta-globulin gene locus. The method for improving the gene targeting efficiency comprises the following steps of: S10, determining a gene locus to undergo in-situ repair; and S20, introducing a CRISPR / Ca system to cleave editing lotus DNA to cause DNA damage and simultaneously providing a repair template segment. Based on the deficiency of existing gene modification, the gene modification efficiency, the timeliness and the modification quality are improved after single-stranded oligonucleotides (ss ODNs) and a small molecule compound participate in a CRISPR / Cas9 gene modification system.
Owner:THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
Denatured lactoglobulin and polyphenol coassemblies
ActiveUS20120093933A1Improve colloidal stabilityLess bitterPowder deliveryBiocideNanoparticlePolyphenol
The present invention is directed to co-assembled nanoparticle composition comprising denatured β-lactoglobulin and at least one nutraceutical compound, specifically polyphenols, such as EGCG, compositions comprising same and methods of preparing thereof.
Owner:TECHNION RES & DEV FOUND LTD
Compositions comprising a casein and methods of producing the same
ActiveUS20170273328A1Improve flavor profileReduce removalMilk preparationFrozen sweetsCrystallographyCasein
Disclosed herein are methods and compositions including casein, and methods for making these compositions.
Owner:PERFECT DAY INC
Compound and method for the prevention and/or the treatment of allergy
InactiveUS20030152581A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntigenActivation cells
The present invention is related to a compound for the prevention and / or the treatment of allergy consisting of: at least one allergen antigenic determinant which is recognised by a B cell or an antibody secreted by a B cell of a non-atopic individual to said allergen, and at least one antigenic determinant of an antigen different from said allergen which triggers T cell activation.
Owner:SAINT REMY JEAN MARIE +1
Compositions comprising a casein and methods of producing the same
ActiveUS20170164632A1Improve flavor profileReduce removalMilk preparationFrozen sweetsCrystallographyCasein
Disclosed herein are methods and compositions including casein, and methods for making these compositions.
Owner:PERFECT DAY INC
Characteristic peptide combination and method for detecting adulterate ratio of powdered milk in goat milk powder
InactiveCN106749598AQuantitativeRealize the quantification of adulteration ratioComponent separationBiological testingLinearityPeptide fragment
The invention discloses a characteristic peptide combination and a method for detecting the adulterate ratio of powdered milk in goat milk powder. The characteristic peptide combination comprises milk characteristic peptides and goat milk characteristic peptides, wherein the amino acid sequence of the milk characteristic peptides is LSFNPTQLEEQCHI, and the amino acid sequence of the goat milk characteristic peptides is LAFNPTQLEGQCHV. Through the application of the characteristic peptide combination disclosed by the invention, the adulterate ratio of the powdered milk in the goat milk powder can be quantitatively detected by using a high performance liquid chromatography-mass spectrometry combined technology, the method is relatively high in linearity, sensitivity, recovery rate and accuracy rate, and characteristic peptide fragments in a protein are selected as detection substances and are applicable for detection of denatured protein, so that natured and denatured proteins in a detection sample can be detected simultaneously, and the accuracy of the method is guaranteed.
Owner:杭州帕匹德检测技术服务有限公司
Immunogenic peptides and their use in immune disorders
ActiveUS9249202B2High expressionNervous disorderAntibody mimetics/scaffoldsAutoimmune diseaseImmunogenic peptide
Owner:IMCYSE
Synthesis and structure of high potency RNA therapeutics
ActiveUS20190002906A1Increased cytoplasmic half-lifeExtended half-lifeApolipeptidesFibrinogenProtein targetArabis
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
Owner:ARCTURUS THERAPEUTICS
Systems, compositions, and methods for transplantation and treating conditions
Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and / or to prolong the half-life of the protein for treating wounds.
Owner:CYTONICS CORP
Milk protein production in transgenic plants
Owner:ALPINE ROADS INC
Recombinant fusion proteins for producing milk proteins in plants
ActiveUS10947552B1Stable expressionFabaceae cultivationVector-based foreign material introductionBiotechnologyMicrobiology
Provided herein are compositions and methods for producing milk proteins in plants, which allow for safe, sustainable and humane production of milk proteins for commercial use, such as use in food compositions. The disclosure provides recombinant fusion proteins comprising a milk protein, or fragment thereof and a structured mammalian, avian, plant, or fungal protein, or fragment thereof. The disclosure also provides methods for producing the recombinant fusions proteins, and food compositions comprising the same.
Owner:NOBELL FOODS INC
Whey Protein Isolate Hydrogels and Their Uses
A biodegradable hydrogel has been made based on high concentrations of whey protein isolate (WP1). WP1 gels of different compositions were fabricated by thermally inducing gelation of high-concentration suspensions of protein, and characterized for compressive strength and modulus, hydration swelling and drying properties, mechanical behavior change due to polysaccharide additives, and intrinsic pore network structure. The gels were shown to be compatible with bone cells and could be used as bone tissue scaffolds. In addition, WP1 fibers were produced by electrospinning. Several additives could be incorporated into the WPI gels, including structural additives, growth factors, amino acids, etc. The WP1 hydrogels can be made with glycerol to increase flexibility and stability. The hydrogels could be used for tissue regeneration, food protection, controlled-release applications (including drug encapsulation, dietary supplement release, attractant release in lures, nutrient release to plants (fertilizers), column packing for compound separation, and membrane development.
Owner:BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV & AGRI & MECHANICAL COLLEGE
Systems, compositions, and methods for transplantation and treating conditions
Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and / or to prolong the half-life of the protein for treating wounds.
Owner:CYTONICS CORP
Ultrasound-assisted simulated digestion method of milk protein active peptide and application thereof in health foods
ActiveUS20200157142A1Lower blood pressureGood anti-inflammatory effectPeptide preparation methodsFermentationBiotechnologyMilk protein
An ultrasound-assisted simulated digestion method of a milk protein active peptide and an application thereof in health foods, pertaining to the technical field of intensive processing of dairy products and preparation of health foods. The method firstly employs ultrasonic pretreatment of casein and β-lactoglobulin, followed by enzymatic hydrolysis with a protease to prepare casein and β-lactoglobulin polypeptide, and traces the activity of the polypeptide by simulating gastrointestinal digestion, and then simulates absorption by intestinal epithelial cells with Caco-2 cells, to characterize a highly active milk protein polypeptide digested by the gastrointestinal tract and absorbed by the Caco-2 cells simulating absorption by the inner wall of the small intestine. The method has identified five such highly active milk protein polypeptides.
Owner:JIANGSU UNIV
Paclitaxel immunogen, anti-paclitaxel specific antibody and paclitaxel detection reagent
InactiveCN104530222AStrong specificityReduce testing costsSerum immunoglobulinsSerum albuminImmunogenicitySpecific antibody
The invention discloses a paclitaxel immunogen and a synthetic method of the paclitaxel immunogen as well as an anti-paclitaxel specific antibody and a detection reagent obtained by the paclitaxel immunogen and a preparation method thereof. The paclitaxel immunogen prepared by the invention is high in immunogenicity, can be induced to obtain a high titer anti-paclitaxel specific antibody and is free of any cross reactions with 62 common medicines. The paclitaxel detection reagent prepared by the antibody can be used for precisely and quickly determining the content of paclitaxel in a sample. Compared with existing detection reagents in the market, the detection reagent has the advantages of being simple and convenient to operate, high in sensitivity, strong in specificity, accurate in result and the like and can be used for effectively lowering the paclitaxel detection cost, thereby facilitating clinical large-scaled popularization and use.
Owner:苏州博源医疗科技有限公司
Method for extracting plasma protein powder from pig blood
InactiveCN105132399ATake advantage ofPromote absorptionFermentationAnimals/human peptidesHemolysisSolvent
The invention provides a method for extracting plasma protein powder from pig blood. The method comprises the following steps of preparing anticoagulation pig blood; separating plasma from haemocyte; depositing the plasma to collect prothrombin; preparing crude thrombin liquid; preparing fine thrombin products; breaking walls and performing hemolysis of the haemocyte; performing enzymolysis of hyperglobulinemia by segment; preparing hydrolyzed protein of the pig blood. The method has the beneficial effects that the amino acid content of the hydrolyzed protein of the pig blood is more than 90% of protein, the hydrolyzed protein of the pig blood is easy to absorb and utilize, raw materials are fully utilized, and two high added-value products can be produced by once charging. In the whole process of production, organic solvents with large toxicity are not used, the defects of product singleness, solvent residue and the like are overcome, and the production cost is reduced.
Owner:HAIAN HUARUN FOOD
Bioactive Peptides and Proteins Containing Bioactive Peptides, their Uses and Processes for Making the Same
InactiveUS20140011742A1Improve arterial functionGood blood pressurePeptide/protein ingredientsImmunoglobulinsBioactive peptideDigestion
A process for treating a protein before hydrolytic digestion, the process comprising exposing the protein to at least one cycle of microwave irradiation to produce a microwave treated protein containing one or more bioactive peptides. Further hydrolyzing the microwave treated protein to release at least one of the one or more bioactive peptides. A pharmaceutical composition, supplement and food product including the microwave treated protein or the one or more released bioactive peptides.
Owner:MCGILL UNIV
Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), are also provided.
Owner:TAKEDA PHARMA CO LTD
Method for separating milk-derived whey proteins in PEG/phosphate aqueous two-phase system
ActiveCN103524612AAchieve separationSimple and fast operationAlbumin peptidesPeptide preparation methodsPhosphateSeparation technology
Owner:JINAN UNIVERSITY
Recombinant milk proteins
ActiveUS10894812B1Stable expressionPolypeptide with localisation/targeting motifFusion with protease siteBiotechnologyMilk protein
Provided herein are compositions and methods for producing recombinant milk proteins, as well as food compositions comprising the same. In aspects, the recombinant milk proteins of the disclosure are recombinant fusion proteins comprising casein and beta-lactoglobulin.
Owner:NOBELL FOODS INC
Method for knocking out cattle beta-lactoglobulin gene by using zinc finger nucleases (ZFNs)
InactiveCN102212545AKnockout convenienceHigh knockout efficiencyHydrolasesArtificial cell constructsEmbryoSomatic cell
The invention provides a method for knocking out a cattle beta-lactoglobulin gene by using zinc finger nucleases (ZFNs), comprising the following steps of: according to a cattle beta-lactoglobulin gene sequence, designing ZFNs specific site expression vector and transplanting the ZFNs specific site expression vector into cattle fibroblast; and obtaining cells with the beta-lactoglobulin gene knocked out. By using ZFNs mediated gene knockout, one-time transfection can be realized so as to obtain cell clones with biallelic genes knocked out, which is difficultly achieved in the conventional gene targeting process. The drug screening process is saved. The method disclosed by the invention is advantageous for forming monoclonal cells. The process required by cells for resisting drug toxic process is avoided. The method plays a key role in the improvement of subsequent somatic cell nuclear transplantation efficiency and embryonic development quality. Simultaneously, resistance genes are not contained; and the biological safety evaluation process is greatly simplified.
Owner:BEIJING GEFUCURE BIOTECHNOLOGY LIMITED COMPANY
Method for separating beta-lactoglobulin from desalted whey powder
InactiveCN103923202AEasy to operateSimple processPeptide preparation methodsAnimals/human peptidesUltrafiltrationSalting out
The invention discloses a method for separating beta-lactoglobulin from desalted whey powder. According to the method, desalted whey powder is used as a treatment object which is subjected to ammonium sulfate salting out, primary ultrafiltration desalting, primary ion-exchange column chromatography, secondary ultrafiltration desalting, secondary ion-exchange column chromatography, gel chromatography and final separation so as to obtain beta-lactoglobulin with relatively high purity. Compared with the prior art, the method has the advantages that firstly, the operation is convenient, the process is simplified, related requirements are lowly required, and the operation can be carried out in a small laboratory; secondly, operators are lowly required, and the popularization and the application are convenient; thirdly, beta-lactoglobulin is relatively high in separation purity, the strip is clear and the separation is thorough; fourthly, the application range is wide, and different varieties of protein can be separated.
Owner:CHINA JILIANG UNIV
Recombinant milk proteins
ActiveUS11034743B1Stable expressionPolypeptide with localisation/targeting motifFusion with protease siteBiotechnologyMilk protein
Provided herein are compositions and methods for producing recombinant milk proteins, as well as food compositions comprising the same. In aspects, the recombinant milk proteins of the disclosure are recombinant fusion proteins comprising casein and beta-lactoglobulin.
Owner:NOBELL FOODS INC
Lentiviral protein delivery system for rna-guided genome editing
The invention is directed to a system comprising a lentivirus vector particle which encodes at least one guide RNA sequence that is complementary to a first DNA sequence in a host cell genome, a Cas9 protein, and optionally a donor nucleic acid molecule comprising a second DNA sequence. The invention also is directed to a method of altering a DNA sequence in a host cell using such a system, where the host cell can be in a human and the altered DNA can be of the human β-globin gene. The invention also is directed to a fusion protein comprising a Cas9 protein and a cyclophilin A (CypA) protein. The invention also is directed to sequences of vectors that can be used in the system and method.
Owner:UNITED STATES OF AMERICA
Nucleotide molecule for in-vitro transcription of mRNA, presenting cell and application
ActiveCN111019959AHigh antigen stabilitySustained expression time increasePolypeptide with localisation/targeting motifSsRNA viruses negative-senseAntigen epitopeDendritic cell
The invention provides a nucleotide molecule for in-vitro transcription of mRNA, a presenting cell and application, and relates to the technical field of biology. The nucleotide molecule provided by the invention at least has a nucleic acid sequence shown as SEQ ID NO.3, is used for transcribing at least mRNA with an amino acid sequence shown as SEQ ID NO.1 or / and an amino acid sequence shown as SEQ ID NO.2; the presenting cell is a dendritic cell loaded with the nucleotide molecule for in-vitro transcription of mRNA. The nucleotide molecule for in-vitro transcription of mRNA can be used for preparing an mRNA screening or / and evaluation model, or directly for screening or / and evaluating antigen epitope or mRNA. The nucleotide molecule for in-vitro transcription of mRNA provided by the invention has the advantages of higher stability of mRNA expressed by the nucleotide molecule for in-vitro transcription of mRNA, prolonged continuous expression time, low cost and wide universality; andthe technical problem that the existing tumor antigen vaccine can only present a single antigen is solved.
Owner:北京立康生命科技有限公司
A base editing system, a method, a kit used for specificity repair for human HBB gene mutation and an application therefor
The invention belongs to the field of gene treatment, and specifically relates to a method adopting a base editing system to repair beta thalassemia caused by A>G pathogenic mutation. The provided base editing system specifically repairs the above mutational method, mutational gRNA above specificity targeting and base editing protein. HBB: c.-79A>G and HBB: c.-78 A>G of human can be accurately repaired by utilizing the method. The method is high in efficiency and good in specificity. The gene editing system can be introduced into a somatic cell or individual of human, accurate repair can be performed on the A>G pathogenic mutation, thereby beta thalassemia disease can be cured, and the technology has wide application prospect in the field of gene treatment.
Owner:SUN YAT SEN UNIV
A2m fragments and applications thereof
The application relates to a polypeptide, the amino acid sequence of which is the sequence of a sub-fragment of the C-terminal thioester-cleaved fragment of human alpha-2-macroglobulin (A2M), wherein the molecular weight of said polypeptide is of 36 to 44 kDa, and wherein the first N-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human A2M, is at a position 1,098 or 1,085 or 1,084 or 1,083, and the last C-terminal amino acid of said polypeptide is an amino acid, which, in the full length sequence of said human A2M, is one of the last twenty C-terminal amino acids. This polypeptide is differently abundant depending on the stage of liver fibrosis. The application also relates to means deriving therefrom and to the application thereof, notably in the field of hepatitis.
Owner:BIO RAD INNOVATIONS SAS +1
Recombinant fusion proteins for producing milk proteins in plants
ActiveUS11072797B1Stable expressionFabaceae cultivationVector-based foreign material introductionBiotechnologyMicrobiology
Provided herein are compositions and methods for producing milk proteins in plants, which allow for safe, sustainable and humane production of milk proteins for commercial use, such as use in food compositions. The disclosure provides recombinant fusion proteins comprising a milk protein, or fragment thereof and a structured mammalian, avian, plant, or fungal protein, or fragment thereof. The disclosure also provides methods for producing the recombinant fusions proteins, and food compositions comprising the same.
Owner:NOBELL FOODS INC
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