The invention relates to a novel dust-proof softening detergent for quilt covers and a preparation method thereof. The detergent contains the following components in parts by mass: 0.3-0.7 part of sodium stearyl imidazolinyl carboxylate, 1-3 parts of sodium silicate, 4-9 parts of ester group quaternary ammonium salt, 3-9 parts of siloxane emulsion, 6-15 parts of sodium dimethyl benzenesulfonate, 20-30 parts of high-carbon fatty alcohol polyethenoxy ether, 0.2-0.5 part of fluorescent whitening agent, 0.1-0.4 part of essence, 0.07-0.25 part of citric acid, 3-7 parts of glycerin monostearate, 1-5 parts of methylchloroisothiazolinone, 1-6 parts of isopropyl palmitate, 0.5-1.5 parts of potassium xylenesulfonate and 52-68 parts of water. The detergent provided by the invention can easily remove skin grease, sweat stains, blood stains, oil stains and other stains on the quilt cover surface, and has the sterilizing and softening functions.