55 results about "Treatment infertility" patented technology

A method is provided for the improvement of implantation rates and / or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective amount of (a) a nitric oxide synthase substrate, a nitric oxide donor, or both, optionally in combination with (b) a progestin, and, (c) optionally, in further combination with an estrogen. A method is also provided for fertility control for a female mammal, comprising administering to a female mammal in whom pregnancy is not desired and at risk for becoming pregnant an effective amount of nitric oxide synthase inhibitor in combination with an antiprogestin. Pharmaceutical compositions are also provided.

"The present invention provides non-peptidic amino derivatives, their therapeutic use as well as pharmaceutical compositions that possess activity as Follicle Stimulating Hormone (FSH) agonists and are useful in the treatment of infertility. In particular, the invention provides derivatives."

A method is provided for the improvement of implantation rates and / or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective amount of (a) a nitric oxide synthase substrate, a nitric oxide donor, or both, optionally in combination with (b) a progestin, and, (c) optionally, in further combination with an estrogen. A method is also provided for fertility control for a female mammal, comprising administering to a female mammal in whom pregnancy is not desired and at risk for becoming pregnant an effective amount of nitric oxide synthase inhibitor in combination with an antiprogestin. Pharmaceutical compositions are also provided.

The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc receptor (FcRn) and a second polypeptide including a beta subunit of FSH (βFSH) linked directly or indirectly to an FcRn binding partner. In one embodiment the FcRn binding partner includes an Fc fragment of an immunoglobulin, e.g., an Fc fragment of IgG. Also provided are methods making and using the fusion proteins of the invention. The invention provides a method for increasing fertility in a subject and a method for treating a subject having a disease state responsive to treatment by FSH.

The invention discloses novel growth hormone releasing hormone analog peptides and an application thereof in preparing medicines for treating infertility. Experiments discover that 2D, 2E or 2F peptide has obviously high hypophysis GH releasing activity and hypophysis hormone releasing specificity. Tested by the conjugation reaction of an in-vitro GHRH dimer peptide and a hypophysis GHRH receptor, 2D, 2E and 2F dimer peptides have extremely high hypophysis receptor binding activity, wherein the 2F dimer peptide has the maximum binding activity. With the 2F peptide as the representative, infertility model treatment finds out that, compared with a normal saline group and a pure cyclophosphamide control group, in the 2F dimer peptide group, the spermatocytes and the spermatogonia in the seminiferous tubules are obviously increased, the seminiferous tubule cells are arranged in order and large in volume, the cavities of the seminiferous tubules are reduced and even disappear, and dose dependency is shown. All the facts indicate that the GHRH peptides with the 2F peptide as the representative have an obvious effect of stimulating the proliferation and the maturation of spermatogonia / oogonia, thereby promoting reproduction; and as a result, the novel growth hormone releasing hormone analog peptides can be applied to medicines for treating infertility.

The invention relates to a traditional Chinese medicine for treating infertility, which is prepared from the following medicinal materials: prepared rehmannia root, radix rehmanniae, cornus officinalis, semen cuscutae, morinda officinalis, radix achyranthis bidentatae, radix bupleuri, auranti fructus, rhizoma cyperi, cassia twig, angelica sinensis, radix paeoniae alba, radix paeoniae rubra, peach kernels, safflower, cortex moutan, poria cocos and rhizoma alismatis. According to the different physiques and illness states of patients, the medicines and the doses are different, if a patient suffers from static blood blocking in uterine vessel, rubia cordifolia and cuttlefish bone are added, and if the patient also suffers from moist heat, dahurian patrinia herb and sargent gloryvine are added, and the preparation can be decoction, powder or pills. The traditional Chinese medicine is effective in tonifying kidney and nourishing blood, soothing the liver and removing depression, activating blood circulation and dispelling blood stasis, removing dampness and eliminating phlegm, and suitable for treating infertility due to kidney deficiency and hemophthisis, liver stagnation, qi depression and blood stasis and phlegm dampness aggregation, and has the advantages of fast effect, high pregnancy rate and no side effect.

The present invention is directed to a methods and compositions for enhancing the probability that a subject will become pregnant. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a linoleic acid active agent, e.g., linoleic acid, a polyunsaturated fatty acid analog thereof, etc. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of infertility conditions.

The invention discloses compound intrauterine infusion liquid of western medicine and Chinese traditional medicine for treating cow endometritis and a preparation method thereof, the infusion liquid takes oxytetracycline, motherwort herb, peach seed, Chinese angelica, Szechuan lovage rhizome, membranous milkvetch root, liquoric root and a plurality of excipients as raw materials and is prepared by decoction, filtration, concentration, pumping filtration, concentration, spray drying, micro-powderization of oxytetracycline, homogenization and other processes; the infusion liquid has the advantages that firstly, the raw materials constitute the safe, effective and comprehensive infusion liquid which can not only realize the rapid anti-inflammation, but can also restore the functions of the body with the diseases after the inflammation, promote the pregnancy and treat the infertility; secondly, the infusion liquid adopts the formulation of microparticle suspension, the unit solvent drug-loaded amount is great, the drug delivery volume is small, the chemical properties of the drug microparticles are stable, the bioadhesion is stronger, the drug release is sustained, the infusion liquid can be adhered on the cow uterine endometrium for a long time, thus directly stimulating a uterine receptor, ensuring the drug to be fully absorbed as well as better and rapidly playing the roles.

The invention discloses a traditional Chinese medicine composition for treating infertility and a preparation method thereof. The composition comprises the components of dodders, barrenwort, medlar, c. deserticola, codonopsis pilosula, yam, tuckahoe, antlers, raspberries, rhizoma cyperi, radix bupleuri, radix paeoniae alba, angelica, cortex moutan radicis, prepared rehmannia root, and liquorice. The traditional Chinese medicine composition of the invention has reasonable proportion, and any one clinically oral agent or external-use agent can be prepared according to a conventional preparationmethod of traditional Chinese medicine. The composition, in particular matching with meridians buried line therapy, via multiple stimuli effect of acupuncture, medical gut can generate lasting benignstimulation to cutem in process of gradually liquidated absorption with the gut being buried to meridians as foreign proteins so that effect of cutem is more obvious and the composition has exact effect for treating infertility caused by man and woman endocrine disorder, yellow body dysfunction, anovulation, aspermia,atheno-spermia and the like.

The invention discloses a novel growth hormone releasing hormone analogue peptide dimer and an application thereof. The amino acid sequence of the novel growth hormone releasing hormone analogue peptide dimer is as follows: (NH2)X1-ADAIFTNSYR-X12-VLGQLSAR-X21-LLQDIMS--C32-C32-theta-SMIDQLL-X21-RASLQGLV-X12-RYSNTFIADA-X1(NH2), wherein formula is R, RG or RGG; theta is GGR or GR and R or (NH2)X1-ADAIFTNSYR-X12-VLGQLSAR-X21-LLQDIMSRQQGESNQERGARAR--C46-C46-omega-RARAGREQNSEGQQRSMIDQLL-X21-RASLQGLV-X12-RYSNTFIADA-X1(NH2), wherein formula is L, LG or LGG and omega is GGL or GL and L. The growth hormone releasing hormone analogue peptide dimer can improve in vivo or in vitro growth hormone releasing activity and has a longer half life, so that the dimer has wide pharmacological activity, for example, promoting wound healing, promoting cardiac muscle cell reconstruction, improving sleeping quality, promoting proliferation and differentiation of generative cells so as to treat infertility, adjust immunity, reduce weight and treat diabetes.

The invention discloses a traditional Chinese medicine composition for treating luteal phase defect type infertility and menstrual disorder. The traditional Chinese medicine composition disclosed by the invention is prepared from the following components in parts by weight: 1-6 parts of fried radix paeoniae alba, 1-9 parts of common yam rhizome, 1-6 parts of dogwood, 0.5-3 parts of vinegar baked bupleurum root, 1-9 parts of the seed of Chinese dodder, 1.5-9 parts of sliced cornu cervi, 1.5-9 parts of amethyst and 1-6 parts of radix salviae miltiorrhizae. According to the compound composition provided by the invention, by means of syndrome differentiation and treatment, the formula is obtained through a lot of experimental screening under the guidance of theories of traditional Chinese medicines; experimental results show that the traditional Chinese medicine composition is capable of improving the structure and form of ovary mitochondria endoplasmic reticulum, improving structures of endometrial glands and mesenchyme, adjusting ovary secreted active substances E2 and P, reducing endometrium estrogen receptors and progestrone receptors and increasing expression of integrins alpha v and beta 3; therefore, the endometrium receptivity can be increased; the embryo implantation action is promoted; the traditional Chinese medicine composition has the good effect for treating infertility; and furthermore, the traditional Chinese medicine composition is free from toxic and side effect, and safe and reliable to use.

A method of treatment for infertility includes hypnotic suggestions of relaxation and feelings of being pregnant. Also included are acupressure applied to specific selected body sites, and application of a large area magnet to the body surface over the uterus. The acupressure may be applied by acupuncture needles, pressure applied by small blunt sticks, laser light, electro-stimulation, or small strong magnets. The method may be applied by a practitioner. In another embodiment of the invention, the materials are supplied in a kit form including audio and video recordings and implements for application of acupressure by the patient herself.

A method and composition for the treatment of infertility is disclosed. The method relates to using progesterone dilutions, or any other steroid hormone, to treat infertility. The hormone dilution may be administered sublingually, by drops or sublingual tablet or, an intradermal route of administration may be chosen.

The present invention provides a drug combination for the treatment of infertility and its crude drug comprises the medical ingredients with their weight proportions listed as below: 10-20 amounts by weight of Rehmannia, 10-20 amounts by weight of Chinese Peony, 10-20 amounts by weight of Asiatic Dogwood, 10-20 amounts by weight of Chinese Yam, 10-20 amounts by weight of Poria, 15-25 amounts by weight of Astragalus, 15-25 amounts by weight of Codonopsis, 10-20 amounts by weight of Epimedium and 10-20 amounts by weight of Jujube. The compatibility of this drug combination invented is precise, appropriate and possess outstanding curative effects. As shown in many experiments, the drug combination invented is safe and reliable, its toxic & side-effect is low and it has obvious improvement effects on female infertility caused by androgen, fallopian tube inflammation, tubal blockage and other factors. Furthermore, it can not only significantly improve the success rate of pregnancy, but also improve immunity and enhance the body's anti-fatigue and hypoxia tolerance. In short, the invention provides a safe and reliable new choice for clinical medication.

Certain compounds, structurally related to natural compounds which can be extracted i.a. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives. These compounds have the structural formula wherein the substituents are as defined in the specification.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a medicine for treating infertility and a preparation method thereof. The medicine is prepared from fried semen cuscutae, cornu cervi degelatinatum, roasted morinda officinalis, fried eucommia ulmoides, fried teasel roots, fried Chinese yam, fried gorgon fruits, fructus lycii, amomum villosum lour, fried rhizoma atractylodis macrocephalae, codonopsis pilosula, prepared rehmannia roots, angelica sinensis, roasted astragalus membranaceus and roasted liquorice. The medicine for treating infertility is beneficial for increasing the thickness of the endometrium, enhancing the follicle tension, recovering normal development of follicles and enhancing pregnancy assistance.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating infertility and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of radix rehmanniae praeparata, 12-15 parts of radix angelicae sinensis, 25-35 parts of fried rhizoma atractylodis macrocephalae, 15-20 parts of fried rhizoma dioscoreae, 10-12 parts of fried radix paeoniae alba, 9-12 parts of raw semen ziziphi spinosae, 6-10 parts of cortex moutan, 9-12 parts of radix glehniae, 8-10 parts of fried cortex eucommiae, 20-25 parts of radix codonopsis, 6-10 parts of radix bupleuri, 8-12 parts of fried rhizoma cyperi and 6-9 parts of caulis perllae. The traditional Chinese medicine composition for treating infertility, provided by the invention, can improve the curative effects of increasing the thickness of endometrium, enhancing follicle tension and recovering normal development of follicles, and finally effectively assists pregnancy.

The invention relates to a method for preparing a traditional Chinese medicine composition for treating infertility, and belongs to the technical field of traditional Chinese medicines. The method for preparing the traditional Chinese medicine composition for treating infertility comprises the following steps of weighting the following raw materials: folium ginkgo, madder, peach kernels, rhizoma sparganii, fructus evodiae, Chinese yam, poria cocos, Fructus Ziziphi Jujubae, the root of kudzu vine, radix codonopsis and liquorice; and respectively cleaning, drying and pulverizing; and soaking, extracting, filtering, centrifuging, ultra-filtering and concentrating to obtain a Chinese herb extract. The traditional Chinese medicine composition prepared by the invention has effects of warming channels for arresting bleeding, eliminating cold to stop pain, removing stasis and restoring menstrual flow, tonifying the spleen and calming the heart, tonifying middle-jiao and qi and nourishing the blood and tranquilization in the aspects of treatment of female infertility, and has the advantages that simple preparation technology, good curative effect, small side effects, convenience in oral taking, easiness in popularization and application and the like.

The invention belongs to the technical field of infertility traditional Chinese medicine research, and particularly relates to a traditional Chinese medicine composition for treating infertility as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight of 10 to 15 parts of radix angelicae sinensis, 15 to 25 parts of fried rhizoma atractylodis macrocephalae, 20 to 25 parts of fried radix paeoniae alba, 8 to 12 parts of fried rhizoma cyperi, 10 to 12 parts of cortex moutan, 12 to 15 parts of poria cocos, 7 to 9 parts of radix trichosanthis, 4 to 6 parts of fructus meliae azedarach, 10 to 12 parts of fructus liquidambaris, 6 to 12 parts of semen vaccariae and 8 to 12 parts of herba taraxaci. The traditional Chinese medicine composition for treating infertility provided by the invention can reduce the secretin hormone level, increase the endometrial thickness and recover normal development of ovarian follicles, and finally effectively assists pregnancy.

The invention discloses a traditional Chinese medicine composition for treating infertility and a preparation method thereof. The composition is prepared from concha meretricis seu cyclinae, radix achyranthis bidentatae, fructus liquidambaris, cortex magnoliae officinalis, semen vaccariae, patrinia scabiosaefolia, akebia trifoliate, garden balsam stem, fructus trichosanthis, herba leonuri, herba epimedii, fructus ligustri lucidi, turtle shell, saffron crocus, green prickleyash and probiotics. The traditional Chinese medicine composition has a remarkable treatment effect on the infertility.

Methods for treating uterine fibroids, endometriosis, adenomyosis, or heavy menstrual bleeding in a subject, which include administering to the subject from 10 mg to 60 mg per day of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea, and from 0.01 mg to 5 mg per day of a hormone replacement medicament. The present disclosure has methods for reducing menstrual bleeding in a subject, reducing bone mineral density loss in a subject caused by administering a GnRH antagonist to the subject, suppressing sex hormones in a subject, reducing vasomotor symptoms or hot flashes in a subject, and reducing symptoms of decreased libido in a subject having uterine fibroids, endometriosis, or adenomyosis. Further provided are methods of maintaining blood glucose profile, maintaining lipid profile, and / or maintaining bone mineral density in a pre-menopausal woman being treated for one or moreconditions or symptoms of endometriosis, adenomyosis, uterine fibroids, or heavy menstrual bleeding; and methods of contraception and treating infertility.

The invention discloses an herbal preparation for treating infertility. The herbal preparation is prepared from the following herbal medicines: 15-25 parts of codonopsis pilosula, 20-25 parts of angelica sinensis, 15-25 parts of morinda officinalis how, 20-30 parts of earthworm, 10-20 parts of fructus leonuri, 10-20 parts of semen vaccariae, 10-25 parts of fructus liquidambaris, 15-25 parts of cornu cervi degelatinatum, 15-25 parts of cistanche, 25-35 parts of fluoritum, 8-12 parts of photinia parvifolia, 15-25 parts of squama manitis, 20-30 parts of polygonum multiflorum thunb, 15-25 parts of semen cuscutae, 20-30 parts of prepared rhizoma cyperi, 15-25 parts of herba epimedii, 15-25 parts of placenta hominis, 6-12 parts of dicranopteris pedata, 20-30 parts of celosia cristata L, 10-15 parts of high mallow, 10-15 parts of mallotus apelta(lour.)muell.-arg and 20-35 parts of radix paeoniae alba, wherein codonopsis pilosula, angelica sinensis and morinda officinalis function as the Monarch drugs; earthworm, fructus leonuri, semen vaccariae, cornu cervi degelatinatum and cistanche function as the minister drugs; fluoritum, photinia parvifolia and herba epimedii function as the assistant drugs; and high mallow, mallotus apelta(lour.)muell.-arg, crateva unilocularis and radix paeoniae alba function as the guide drugs.

Certain novel sterol derivatives having no hydroxy group in the 3-position can be used to regulate the meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives. These compounds have the structural formula wherein the substituents are as defined in the specification.

A method of inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor. A method for augmenting ovulation in an ovulating female suffering from unexplained infertility or another type of ovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor early in one or more menstrual cycles. A method of substantially reducing dosage levels of follicle stimulating hormone (FSH) for administration to a female undergoing infertility treatment which comprises administering a combination of two or more daily doses of at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). A method of increasing response to a follicle stimulating hormone from a female who is a poor responder to follicle stimulation, which comprises administering a combination of two or more daily doses or at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). Also disclosed are related pharmaceutical preparations and uses.

The invention discloses a medicine for treating gynecological diseases and andrological diseases. The medicine is prepared from cassia twigs, rhizoma sparganic, curcuma zedoary, leeches, earthworms, sargentgloryvine stems, kelp, herba patriniae, polygonum cuspidatum, myrrh, radix aconiti carmichaeli, liquidambar formosana hance, cowherb seeds, asarum, oldenlandia diffusa, fructus cnidii and honey. The medicine for treating gynecological diseases and andrological diseases has the advantages that through the mutual synergistic effect of the medicines, the medicine can be used for treating infertility, abnormal leucorrhea, annexitis, pelvic inflammation, vaginitis, cervicitis, cervical erosion, hysteromyoma, ovarian cyst, uterine prolapse, tubal nowhere, menstrual stomachache, menstrual disorder, amenorrhea, endocrine dyscrasia, habitual abortion, waist soreness and pain after parturition, incomplete lochia and bleeding, sexual apathy, congenital uterine and ovarian dysplasia atrophy, endometriosis and the like, and also can be used for treating male prostatitis, prostatic hyperplasia calcification, varicocele, non-liquefaction of sperms, asthenospermia, oligospermia, testicular dysplasia, epididymitis and other male infertility and other male diseases.

The present invention provides a medicament for treating infertility and a preparing method thereof which is prepared from 10 raw Chinese medicinal components including loranthus, rehmannia glutinosa, salvia, poria cocos, radix cyathulae, zedoary, rhizoma sparganii, angelica, rhizoma corydalis, cyperus rotundus. The medicament is a product combining traditional secret recipe with modern pharmacopoeia, and is a new product prepared by changing traditional decoction. The medicament has better curative effects in supplying qi and nourishing blood, nourishing yin, eliminating blood stasis and promoting tissue regeneration, promoting ingravidation and benefiting mother. The medicament has determinated curative effect for treating woman's qi-blood deficiency, qi-blood stasis, fallopian tube blockage, meridian vessel uncomfortable, amenorrhea, dysmenorrhea, exceptional leukorrhoea, endometriosis uterina, uterine hypoplasia and habitual abortion.

The invention discloses a traditional Kazakhstan externally applied pharmaceutical composition for treating infertility and a preparation method thereof, wherein the pharmaceutical composition is mainly used to prevent and treat infertility by combining a traditional medical theoretical basis: Kazakhstan medical Introduction six-element theory, namely Ozeg alta turor theory; qi, function and energy theory, namely Huvati theory; body liquid theory, namely Sule theory; visceral organ theory, namely Myfeler theory, and the like. An orally taken preparation is prepared from the following traditional common medicinal plants in Kazakhstan medicines as raw materials: plant parasite, cortex acanthopanacis, radix angelicae pubescentis, angelica sinensis, monkshood, cinnamon, cortex illicii, homalomena occulta, frankincense, myrrh, flowers carthami, notopterygium root, divaricate saposhnikovia root, rhizoma corydalis, the root of red-rooted salvia, radix clematidis, root of common peony, garden balsam stems and folium artemisiae argyi which are extracted by water and ethanol and uniformly mixed. The preparation comprises all externally applied preparations such as lotion, liniments, pastes, cataplasm, sprays and emulsions suitable for clinically preventing and treating infertility. The pharmaceutical composition disclosed by the invention particularly has better curative effect on adjuvant therapy of oral administration to infertility, and is reasonable in formula, convenient to prepare, exact in curative effect, quick in effect and free from toxic and side effects such as irritancy.

The invention provides a wearable acupoint therapeutic apparatus for relieving or treating infertility, which is worn at the Sanyinjiao acupoint of the ankle and comprises an acupoint stimulator and a traditional Chinese medicine patch which are matched for use. The acupoint stimulator comprises an electrical stimulation device, an in-vitro controller and a fixing assembly. The electrical stimulation device comprises a shell, an electrical stimulation piece installed on the upper surface of the shell, an electric heating piece arranged in the shell, a signal generator, a signal receiver and an inner controller. The in-vitro controller is mounted on mobile communication equipment, is in communication connection with the in-vitro controller through the signal receiver, and comprises a plurality of condition setting buttons; the fixing assembly comprises fixing belts arranged on the two sides of the shell, and the free end is provided with fixing openings matched with each other. The traditional Chinese medicine patch comprises a carrier and a traditional Chinese medicine agentia added on the carrier, wherein the traditional Chinese medicine agentia comprises the following components: 10 parts of radix rehmanniae preparata, 5 parts of dogwood, 5 parts of angelica sinensis and 5 parts of radix paeoniae alba.

The invention provides a gene related to animal infertility, sgRNA, application and a method for constructing an animal model, and relates to the technical field of animal models. The invention provides a gene related to animal infertility. The gene comprises an animal dguok gene. The sgRNA is designed on the basis of the gene, a female infertility animal model is constructed, the model is 100% infertility, and the expression is that ova cannot be mature, cannot be successfully fertilized, cannot be split and cannot enter an 8-cell stage and a blastocyst stage; and the female infertility mouse model is helpful for deeply researching a specific molecular mechanism of female infertility on a molecular level, and is helpful for researching and developing related medicines for treating infertility.