The invention discloses a health wine for preventing and treating atherosclerosis, prepared from the materials according to following parts by weight per liter of the health wine: 10-20 g of Pinus massoniana needles, 15-30 g of Caulis et Folium Gynostemmatis Pentaphylli, 9-15 g of Fructus Trichosanthis, 3-10 g of Rhizoma Curcumae Longae, 6-12 g of Radix Polygoni Multiflori Preparata, and 3-12 g of Fructus Lycii. The health wine has the effects of replenishing qi to invigorate the spleen, nourishing liver and kidney, and dissipating phlegm and removing blood stasis, and has the special functions of resisting arteriosclerosis, lowering blood lipid, resisting oxidation, resisting coagulation, resisting inflammation, clearing free radicals, preventing aging, controlling cancers, enhancing immunity, lowering blood glucose, lowering blood pressure and the like. The health wine of the invention has significant effect in treating atherosclerosis with symptoms, such as dizziness, headache, limb numbness, palpitation, chest distress, shortness of breath, unsmooth speech, hemiplegia, neck discomfort, precordial pain, lower limb limping, red tongue with petechiae at edge, thick white greasy coating, and thready, unsmooth, wiry and slippery pulses.