61 results about "Pulmonary tumor" patented technology

The invention relates to exosome as well as a preparation method and application thereof in preparing medicines for treating lung cancer. The preparation method comprises a step of stimulating cells to secrete the exosome by using KRN7000 and ATP (Adenosine Triphosphate). By adopting the preparation method provided by the invention, efficient in-vitro exosome preparation can be achieved. The invention further provides the exosome prepared by using the method. The exosome has relatively good cytotoxic effects and lung tumor resistance activity. The invention further provides application of the exosome in preparing medicines for treating lung cancer.

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and / or treatment of diseases, particularly lung cancer.

The present invention relates to pharmaceutical compositions, methods and kits that provide for the early diagnosis and treatment of lung cancer. More particularly, the present invention relates to pharmaceutical compositions containing uteroglobin for preventing or inhibiting metastasis of lung tumor cells and methods of using the same to prevent or inhibit metastasis of lung tumor cells. The present invention also relates to methods and kits for early diagnosis of metastatic lung cancer by assaying for uteroglobin and comparing the results against control cells. The present invention also relates to methods and kits for detection of metastatic lung cancer by assaying for the presence of an aberrant form of uteroglobin.

The present invention relates to pharmaceutical compositions, methods and kits that provide for the early diagnosis and treatment of lung cancer. More particularly, the present invention relates to pharmaceutical compositions containing uteroglobin for preventing or inhibiting metastasis of lung tumor cells and methods of using the same to prevent or inhibit metastasis of lung tumor cells. The present invention also relates to methods and kits for early diagnosis of metastatic lung cancer by assaying for uteroglobin and comparing the results against control cells. The present invention also relates to methods and kits for detection of metastatic lung cancer by assaying for the presence of an aberrant form of uteroglobin.

The invention relates to a medical lung MRI image segmentation method based on an adaptive contour model, and MRI equipment. The equipment comprises a main magnet system, a gradient magnetic field system, a radio frequency system and an operation and image processing system; the radio frequency system comprises a plurality of radio frequency coils which are respectively arranged in coil fixing devices, and different radio frequency receiving coils correspond to different detection parts on a patient. The method comprises the following steps: 1) preprocessing an input fused MRI image; 2) setting an initial contour line as c0 and setting the initial contour line as a circle according to the characteristics of the lung tumor image, and calculating an initial level set function phi 0 accordingto the c0; 3) updating a level set function phi n, and calculating c1 and c2 according to the current phi n; 4) checking whether iteration is convergent or not: if so, determining that c is the optimal contour line, and otherwise, continuing iteration; 5), after the target area is obtained, removing noise and some tiny protruding parts by using image morphological opening operation, smoothing theboundary, connecting the fracture part by using closed operation, and filling a cavity to obtain a target image. The method is high in segmentation precision and clear in edge, and is suitable for segmenting lung MRI images with fuzzy targets, weak edges, smooth boundaries, discontinuous boundaries and complex topological structures.

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and / or treatment of diseases, particularly lung cancer.

The invention relates to a dry powder inhaler and specifically relates to a dry powder inhaler produced by a toad skin extract, a preparation method of the dry powder inhaler and an application of the dry powder inhaler in preparation of medicaments for treating tumors of the lung. The toad skin extract dry powder inhaler is characterized by comprising the toad skin extract and pharmaceutically acceptable excipients, and the weight ratio of the toad skin extract to the excipients is (1:0)-(1:110). The dry powder inhaler produced by the toad skin extract can direct act on patients with lung diseases, reduce the occurrence of toxic and side effects, improve the bioavailability of the medicament, overcome the shortcomings of low effect taking speed, first-pass effect of the liver, systemic toxic and side effects, lower bioavailability and the like of oral preparations, and simultaneously solve the problems of inconvenience in use, poor patient compliance and the like of injections.

The invention relates to a dry powder inhaler and specifically relates to a dry powder inhaler produced by a toad skin extract, a preparation method of the dry powder inhaler and an application of the dry powder inhaler in preparation of medicaments for treating tumors of the lung. The toad skin extract dry powder inhaler is characterized by comprising the toad skin extract and pharmaceutically acceptable excipients, and the weight ratio of the toad skin extract to the excipients is (1:0)-(1:110). The dry powder inhaler produced by the toad skin extract can direct act on patients with lung diseases, reduce the occurrence of toxic and side effects, improve the bioavailability of the medicament, overcome the shortcomings of low effect taking speed, first-pass effect of the liver, systemic toxic and side effects, lower bioavailability and the like of oral preparations, and simultaneously solve the problems of inconvenience in use, poor patient compliance and the like of injections.

The invention discloses an automatic delineation method and delineation system for a lung tumor, a calculation device and a storage medium. The method comprises the following steps: collecting planned CT images, binary images of the lung tumor and binary images of a lung region of a preset number of lung tumor patients before radiotherapy; performing three-dimensional cutting on the divided planned CT image and the corresponding binary image, and extracting a tumor region; taking the planned CT image in the tumor area as input, taking the binary image of the lung area as output, and training to obtain a lung area segmentation model A; taking the segmentation result of the lung region and the preprocessed planned CT image in the tumor region as input, taking the binary image of the lung tumor as output, and training an obtained lung tumor segmentation optimization model B; and processing a planned CT image of a to-be-tested lung tumor patient, and sequentially inputting the processed planned CT image into the trained lung region segmentation model A and the lung tumor segmentation optimization model B to obtain a lung tumor segmentation result.

Methods are provided for identifying whether a tumor, and especially a lung tumor, will be responsive to treatment with a therapeutic regimen that contains a platinum-based agent such as cisplatin andoptionally contains a taxane. A specific Schlafen family member 11 (SLFN11) fragment peptide is precisely detected and quantitated by spectrometry directly in lung cancer cells collected from lung tumor tissue obtained from a cancer patient. Comparison to reference levels determines if the cancer patient will respond positively or negatively to treatment with the chemotherapeutic agents taxane plus a platinum-based agent such as cisplatin.

The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung cancer and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens from lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeting phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorubicin, the efficacy of these drugs against human lung cancer xenografts was improved, the survival rate increased, and the drug toxicity was reduced.

The invention discloses a lung tumor biopsy and radiation particle implantation device under CT positioning, and relates to the technical field of lung tumor treatment, the lung tumor biopsy and radiation particle implantation device comprises a top plate, a fixing plate is arranged at the bottom of the top plate, a bottom plate is fixedly connected to one side of the fixing plate, and a transmission box is fixedly connected to one side of the fixing plate and located above the bottom plate; a second lead screw is rotationally connected to one side of an inner cavity of the transmission box. A threaded rod is rotationally connected to one side of the inner cavity of the transmission box and located below the second lead screw. The lung tumor biopsy and radioactive particle implantation device under CT positioning is provided with a third electric telescopic rod, a limiting groove and a cover plate; so that when a pressure sensor detects that the weight of the top of a detection plate is small and represents that particles in one particle box are used up, a third electric telescopic rod pushes a new particle box to move to the position above a through hole. Therefore, the device can automatically supplement particles, and medical staff do not need to frequently supplement radioactive particles in an operation.

The present invention is a method for manufacturing an animal model for researching a pulmonary tumor and a use thereof. A transgenic non-human animal of the present invention is prepared by embryonic gene microinjection and possesses a tissue-specific expression of vascular endothelial growth factor A165 (VEGF-A165) in lung. Through the expression of vascular endothelial growth factor A165, the lung cells in the transgenic non-human animal of the present invention have inflammatory, vascularogenesis and angiogenesis responses or induce lung tumors. Thus, the non-human animal of the present invention can serve as an animal model for analyzing the regulation and the anti-tumor drugs screening of pulmonary adenocarcinoma.