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Toad skin extract dry powder inhaler, as well as preparation method and application thereof

A technology of dry powder inhalation and extract, which is applied in the field of preparation of drugs for the treatment of lung tumors, to achieve the effect of quick onset, improvement of therapeutic effect, and rapid absorption

Active Publication Date: 2013-03-13
贺州市八步区市场监督管理局
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the study of toad skin extract dry powder inhalation with anti-lung tumor effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of toad skin extract: wash the dried toad skin, add 10 times the amount of water, decoct twice for 1.5 hours each time, combine the filtrates, concentrate to a relative density of 1.1-1.2 (85 ° C), cool to 40°C, add ethanol to precipitate to make the alcohol content reach 60%, let stand for 24 hours, take the supernatant to recover ethanol until there is no alcohol smell, add ethanol to the concentrate to make the alcohol content reach 85%, let stand for 48 hours, filter , recover ethanol to thick paste, and dry at 60°C to obtain toad skin extract.

[0033] 2. Preparation of inhalant: pulverize the toad skin extract to D 50 Below 5 microns, mix with lactose with a particle size of 45-70 microns at a mass ratio of 1:10, and pack the drug powder into capsules or blister or dry powder inhalers to obtain inhalers.

Embodiment 2

[0035] 1. Preparation of toad skin extract: take the dried toad skin and wash, add 12 times the amount of water, decoct twice, 2 hours each time, combine the filtrates, concentrate to a relative density of 1.2-1.3 (85 ° C), cool to 40°C, add ethanol to precipitate to make the alcohol content reach 70%, let stand for 24 hours, take the supernatant to recover ethanol until there is no alcohol smell, add ethanol to the concentrate to make the alcohol content reach 85%, let stand for 48 hours, filter , recover ethanol to no alcohol smell, spray dry to obtain toad skin extract powder, powder D 50 below 5 microns.

[0036] 2. Preparation of inhalant: Mix the toad skin extract powder, lactose with a particle size of 45-80 microns, and leucine with a particle size of 20-50 microns in a mass ratio of 10:100:1, and package them into The inhaler is obtained in a capsule or blister or dry powder inhaler.

Embodiment 3

[0038] 1. Preparation of toad skin extract: take the dried toad skin and wash it, add 30 times the amount of water, microwave-assisted extraction for 3 times, 1 hour each time, combine the extracts, go through the ultrafiltration membrane with a molecular weight of 1000 and ultrafiltration, the ultrafiltrate Spray drying to obtain toad skin extract powder, powder D 50 below 5 microns.

[0039] 2. Preparation of inhalant: Pack the toad skin extract powder into capsules, blister packs or dry powder inhalers to obtain inhalers.

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PUM

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Abstract

The invention relates to a dry powder inhaler and specifically relates to a dry powder inhaler produced by a toad skin extract, a preparation method of the dry powder inhaler and an application of the dry powder inhaler in preparation of medicaments for treating tumors of the lung. The toad skin extract dry powder inhaler is characterized by comprising the toad skin extract and pharmaceutically acceptable excipients, and the weight ratio of the toad skin extract to the excipients is (1:0)-(1:110). The dry powder inhaler produced by the toad skin extract can direct act on patients with lung diseases, reduce the occurrence of toxic and side effects, improve the bioavailability of the medicament, overcome the shortcomings of low effect taking speed, first-pass effect of the liver, systemic toxic and side effects, lower bioavailability and the like of oral preparations, and simultaneously solve the problems of inconvenience in use, poor patient compliance and the like of injections.

Description

Technical field: [0001] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of toad skin extract, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique: [0002] Cinobufacin is an extract obtained by extracting and purifying the dried skin of Bufobufo gargarizans Cantor, an animal of the Bufonidae family. It has the effects of detoxification, swelling, and pain relief. etc., the physiologically active substances are mainly bufotoxins and their hydrolysis products bufageins, bufoteinines and so on. At present, cinobufacin injections, oral liquids, and tablets have been used clinically, and have good curative effects on liver cancer, lung cancer, and gastric cancer. In particular, cinobufacin injection, which is a water-soluble preparation processed from the skin of Bufo bufo, has achieved comprehensive effective rates of 44% and 56% in the treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/72A61K9/14A61P35/00A61K35/65
Inventor 陈彦张振海贾晓斌王晋艳贺俊杰
Owner 贺州市八步区市场监督管理局
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