32 results about "Prohibition of drugs" patented technology

The invention discloses a wearable / handheld personal communication device with hardware and software sensor modules that sense and analyze all caregiver prescribed / monitored user-lifestyle activities, and deploys such analysis in improving user's overall health in terms of reduced risks for all-cause morbidities / mortalities and eventually a life without drugs. Termed Rx Zero, such method may be prescribed not just for maintaining a healthy lifestyle, but for treatment of chronic diseases with intent to wean the patients to minimal or zero pharmacological intervention, or in combination with medications to improve prognosis of the disease under treatment.The benefits of the Rx Zero method of the present invention extend not only to the individual and the community through high quality healthcare at lower cost, but payers by reducing the loss ratio on account of reduced cost of medical claims, and to the caregivers in terms of an effective tool that disseminates, implements and redefines “Primary Health Care” and “Prevention” at levels beyond the terms' currently understood scope that has transformed healthcare to sickcare.

The invention discloses a wearable / handheld personal communication device with hardware and software sensor modules that sense and analyze all caregiver prescribed / monitored user-lifestyle activities, and deploys such analysis in improving user's overall health in terms of reduced risks for all-cause morbidities / mortalities and eventually a life without drugs. Termed Rx Zero, such method may be prescribed not just for maintaining a healthy lifestyle, but for treatment of chronic diseases with intent to wean the patients to minimal or zero pharmacological intervention, or in combination with medications to improve prognosis of the disease under treatment.The benefits of the Rx Zero method of the present invention extend not only to the individual and the community through high quality healthcare at lower cost, but payers by reducing the loss ratio on account of reduced cost of medical claims, and to the caregivers in terms of an effective tool that disseminates, implements and redefines “Primary Health Care” and “Prevention” at levels beyond the terms' currently understood scope that has transformed healthcare to sickcare.

The present disclosure relates to systems and methods for scanning refuse (garbage, trash) from a large geographic area to detect the presence of hazardous materials in the refuse. Hazardous material may comprise CBRNE agents, components of terrorist devices, environmental pollutants and toxins and illegal drugs and may include trace particulates of such agents as well as by-products thereof. Systems and methods, according to some embodiments, may further comprise geo-locating to a small geographic area the origin of hazardous material. Accordingly, in some embodiments the disclosure provides systems and methods to geo-locate facilities or addresses where hazardous materials are generated, thereby geo-locating facilities that make terrorist devices, sources of environmental pollutants and / or sources of illegal drugs. According to some embodiments, systems and methods of the disclosure enable focusing efforts of law enforcement authorities to identify terrorists, drug activities and / or environmental offenders to small geographic areas (e.g. a street address).

The invention belongs to the technical field of biological engineering, and relates to an NGF-Fc fusion protein and a preparation method thereof. The method comprises the following steps: constructing a human immune globulin IgG Fc and nerve growth factor (NGF) fusion gene expression vector through a genetic engineering means, transferring to a mammal cell to make the transferred mammal cell highly express and produce NGF-Fc fusion proteins, purifying, identifying and carrying out biological activity detection. The expression vector transferred mammal cell constructed in the invention can express bioactive NGF-Fc fusion proteins, so the expression level can be 150mg / L or above, and the obtained protein has good stability and long half life, and can be used to prepare drugs for treating Alzheimer's disease, diabetic peripheral neuropathy, Parkinson's disease, facial neuritis, craniocerebral trauma, trauma of spinal cord, acute cerebrovascular disease, encephalatrophy and other neurological diseases, and peripheral nerve injury acute cerebral vascular central nerve injuries induced by chemical drugs.

The invention relates to an application of a lead compound namely L-corydalmine (L-CDL) of isoquinoline compounds on treating diseases related with addiction. The diseases comprise drug addiction (heroin, opium, methyl amphetamine, morphine, marihuana, cocaine, and the like), nicotine addiction, and alcohol addiction, and also comprise novel drug addiction (stimulant type novel drugs) and brain damage caused by novel drugs.

An illegal drug sensing device provides a sensor coupled to a processor which evaluates the likely presence of illegal drug consumption and / or manufacture at a particular location. Upon the processor determining that such a condition is likely, an alarm is transmitted to at least one of locally or remotely such as through wired or wireless systems which are employed to alert at least one interested party such as the authorities (i.e., the police department) or a land owner of the likely presence of illegal drug activity at the premises.

The present invention relates to a system for combating the psychological craving for drugs of new drug addicts. The system is characterized in that it includes a viewing device based on panoramic technology and an electrocardiometer, and the addict wears the viewing device and the electrocardiometer to monitor the HRV value of the addict; Panoramic technology watches drug use scenes and hears the sound effects of drug use props; the addict uses virtual reality technology to watch drug-related disgust scenes and hear complication-related sound effects through virtual reality technology, using its enhanced The immersive experience presents audio-visual content that induces addicts' memory of drug use, and achieves the purpose of extracting drug-related memory.

The invention belongs to the field of drug monitoring, and discloses an online monitoring instrument for a drug. The online monitoring instrument comprises an analysis control system, a spectrometer, an optical fiber, an optical amplifier, a sensor and communication equipment, wherein the analysis control system is connected with the spectrometer, and the spectrometer is respectively connected with the optical fiber and the communication equipment; the tail end of the optical fiber is connected with the optical amplifier, and the optical amplifier and the sensor are arranged at an interval; the sensor is connected with the communication equipment. The invention also discloses the online monitoring method for the drug. The method comprises the following steps of: transmitting an optical signal, amplifying the signal, penetrating through a detection space, receiving the signal, drawing spectra, analyzing the spectra, sending early warning and the like. The police force can be saved, the normal business of hotels is not interfered, and the drug inspection efficiency is high. The online monitoring instrument can monitor whether a drug abuse situation occurs or not in a room on line, and timely reports to police when the drug abuse situation occurs. The online monitoring instrument for the drug has the advantages of low cost and good effects and is suitable for popularization.

The invention discloses a drug addiction degree detection method, a computer system is used for drug addiction degree detection, and an adopted detection system is composed of a behavioristics module,a drug addiction stimulation module, a data acquisition module, a CNN model establishment module, a CNN classification module and a result evaluation module. The method comprises the following operation steps: 1) collecting behavioral indexes; 2) stimulating the response of drug addicts to drugs; 3) collecting near-infrared data; and 4) establishing a CNN model. 5) performing CNN classification;and 6) evaluating a result. The method solves the problem that the addiction degree of the drug addiction personnel can only be defined according to artificial subjective factors. According to the method, the artificial intelligence method is used for classifying physiological data of mild, moderate and severe drug addiction personnel, and the average accuracy is 75%. According to the method, drugaddiction degree definition is more objective and standardized, and drug rehabilitation and rehabilitation trend is more scientific, reasonable and humanized.

The invention relates to a non-contact relapse monitoring method and system for drug addicts. The monitoring method comprises the following steps: physiological characteristic acquisition: directly collecting or indirectly calculating physiological characteristics of a testee through a non-contact sensor assembly; drug relapse probability evaluation model establishment: acquiring relapse symptomsand clinical sign data of a drug addict as training samples, and performing training through a statistical learning method, a machine learning method or a deep learning method to generate the drug relapse probability evaluation model; and suspect judgment: inputting the physiological characteristics of the testee to the drug relapse probability evaluation model, and outputting the probability of drug relapse of the testee.

The invention discloses a method for investigating an illegal-drug making den based on a soil monitoring technology. The method comprises: surveying a suspected drug-making region, predicting a targetillegal drug, and determining components of finished and semi-finished products and raw making materials of the illegal drug which may exist in soil of the region; setting up sampling points according to the area, terrain and soil structure of the surveyed region to obtain soil samples, analyzing the soil samples and measuring the composition and concentration of the illegal drug; performing soilsample collection on the suspected region where the composition and concentration of the illegal drug are greater than set thresholds, by setting up sampling points for the second time, and reconfirming the composition and concentration of the illegal drug in the soil samples; and determining position information of the drug-making den as well as the type, drug-making level and quantity of the drug in reference to the terrain situation of the suspected region, an atmospheric diffusion model and a principle that water-irrigated soil pollution is uniformly distributed in a band shape accordingto a water flow direction.

The present invention discloses one drug addiction stopping medicine and its preparation process. The medicine is prepared with 62 kinds of Chinese medicinal materials, including licorice, ginseng, Dangshen, American ginseng, etc. The medicine is suitable for stopping addiction of heroin, opium, poppy, marijuanan and other drugs. The medicine has high and determined curative effect, less recurrence, low cost and easy preparation.

The invention discloses a purification preparation method for a cocaine hydrochloride standard substance for forensic science drug detection. The purification preparation method comprises the following steps: (1) detecting purity of cocaine in captured cocaine samples, and selecting a captured cocaine sample of which the cocaine mass fraction is greater than or equal to 60wt% as a raw material for purification preparation of a cocaine hydrochloride standard substance; (2) preparing the cocaine hydrochloride standard substance through high performance liquid chromatography. The cocaine hydrochloride prepared by using the purification preparation method is confirmed through magnetic resonance imaging, liquid chromatography-electrospray tandem mass spectrometry and infrared spectroscopic analysis, the purity of the cocaine hydrochloride is confirmed through liquid chromatography and gas chromatography, and impurities which do not respond to chromatography are tested; according to standard substance study requirements, the stability, the uniformity, the definite values and the total uncertainty of the cocaine hydrochloride standard substance all meet related standards, and expected indexes can be met.

The invention relates to application of roxadustat in preparation of a drug for preventing and / or treating narcotic or drug addiction. The invention discloses that the roxadustat can prevent formation of narcotic or drug addiction behavior after being applied, and can promote regression of the narcotic or drug addiction behavior, so that the prevention and treatment of narcotic or drug addiction or dependence are realized.

A purification method for preparing a codeine standard substance used for forensic scientific drug detection is disclosed. The method includes (1) detecting codeine purities of seized codeine samples, and selecting the codeine sample as a raw material for preparing the codeine standard substance; and (2) preparing the codeine standard substance by utilizing high performance liquid chromatography. The obtained codeine obtained by the method is validated by nuclear magnetic resonance, liquid chromatography-tandem mass spectrometry and infrared spectroscopy analysis, the purity value of the codeine obtained by the method is determined by liquid chromatography and gas chromatography, impurities not responding to chromatography are measured, and according to standard substance development requirements, stability, uniformity, the fixed value and total uncertainty estimation of the prepared codeine standard substance all meet related regulations, thus meeting excepted indexes.

The invention belongs to the technical field of information data processing. The invention discloses a method for establishing a drug addiction relapse time estimation model through a psychological scale. The method comprises the following steps: selecting in- institution personnel and new personnel of a drug abstinence institution who accord with testing object conditions, testing the personnel by using a drug addiction motivation scale tool and a drug abstinence motivation scale tool, and recording and filing the personnel and personal information (demographic variables) of the personnel together; tracking and investigating the time interval (objective index) between the time when testing objects leave the drug abstinence institution and the time when the testing objects enter the drug abstinence institution again due to relapse and the time (subjective index) when the testing objects contact drugs after leaving the drug abstinence institution; performing statistical analysis on thedata by using a statistical method, and establishing statistical models such as a drug addiction motivation scale, a drug rehabilitation motivation scale and demographic variables for predicting the relapse interval time and a drug addiction and rehabilitation motivation intensity division standard; obtaining a psychological health research data sample of the drug abstinence personnel during drugabstinence based on the record data; and providing a feasible method for evaluating the drug rehabilitation effect and the relapse possibility.

The invention discloses a method for analyzing the functional connection of the brain areas of a heroin addict in a task state. The method includes the steps of firstly, using Matlab as the platform,and using SPM8fMRI software to preprocess magnetic resonance imaging data; secondly, building the parameter matrix models of a subject during neutral picture watching and drug-related picture watching; thirdly, calculating to obtain the beta value of each voxel, corresponding to each picture stimulation at each time point, of the whole brain of the subject; fourthly, determining interested areas,and acquiring a whole brain functional connection result graph; fifthly, comparing differences between groups. The method has the advantages that the functional connection of the brain areas of the heroin addict is analyzed in the drug-related clue task state, the whole brain neural activity internal connection of the heroin additive exposed to drugs can be favorably disclosed as compared with analysis in the resting state, and reliable functional imaging evidence is provided for the researches of the heroin addiction mechanism and the curative effect of abstinence treatment.

The invention provides a hair detection method for discriminating drug addicts. The method comprises the following steps: cleaning to-be-detected hair, collecting the cleaned to-be-detected hair and the last washing liquor, quantitatively analyzing the drug content in the to-be-detected hair and the washing liquor, and when the ratio of the to-be-detected hair to the washing liquor is more than 10times and the drug content in the to-be-detected hair is more than or equal to a content threshold, determining that a hair detection result is positive. According to the method provided by the invention, on the basis of the existing hair detection, detection of the drug content in the hair lotion is added, the reliability of the hair detection result for discriminating drug addicts is improved by calculating the ratio of the drug content in the hair to the drug content in the lotion, and a scientific basis is provided for the judgment of suspected drug addicts and the drug addiction time.

The invention discloses a novel application of teprenone, and particularly relates to an application in preparing a drug for preventing and / or treating readdiction in opiates narcotics, and relates to the technical field of medicine. The experiment result shows that after the teprenone is orally taken for 7 days, the conditioned place preference test is carried out on re-addiction mouse after the morphine addiction disappears; when GGA is previously orally taken, the mouse conditioned place preference caused by the readdiction in the morphine can be remarkably inhibited; the expression of NAc-zone NR2B induced by readdiction of morphine can be remarkably inhibited on the molecular level, and the teprenone can be used for preparing the drug for preventing and / or treating opiates narcotics.

The invention discloses a purification preparation method of morphine alkaloid, morphine hydrochloride and a heroin hydrochloride standard substance for forensic science drug detection. The purification preparation method comprises: (1) detecting the purity of heroin hydrochloride in seized heroin samples, and selecting the seized heroin samples having a heroin hydrochloride content of more than or equal to 60 wt% as a raw material for purification preparation of morphine alkaloid, morphine hydrochloride and a heroin hydrochloride standard substance; and (2) preparing the morphine alkaloid, the morphine hydrochloride and the heroin hydrochloride standard substance by using high performance liquid chromatography. According to the present invention, the obtained morphine alkaloid, the obtained morphine hydrochloride and the obtained heroin hydrochloride standard substance are analyzed and confirmed by nuclear magnetic resonance, liquid chromatography-tandem mass spectrometry and infrared spectroscopy, the definite values of the purifies are determined by liquid chromatography and gas chromatography, and the impurities unresponsive to chromatography are determined; and according to the standard substance development requirements, the evaluation of the stability, the uniformity, the definite value and the total uncertainty meets the relevant provisions, and the desired indicators are met.

The invention relates to a compound of structural formula (I) and a non-toxicity pharmaceutically acceptable salt thereof, wherein R represents H or an alkyl group with 1 to 3 carbon atoms; the purpose of any compound or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof is to prepare a drug for treating an addiction disease; and the addiction disease is selected from cocaine addiction, methylamphetamine type drug addiction, opium type drug or medicine addiction, alcoholic addiction, smoking addiction or ketamine addiction.

The invention discloses a far-infrared detection method of drugs. The drugs comprise cocaine, ketamine hydrochloride, cannabinol, morphine and heroin. The far-infrared detection method of the drugs comprises the following steps that 1, standard substance samples of the drugs are prepared; 2, the far-infrared detection technology is used for detecting standard substances of the drugs and constructing a standard dactylogram library; and 3, the constructed standard dactylogram library is used for detecting unknown objects. According to the far-infrared detection method of the drugs, the far-infrared detection technology is used for constructing the fingerprint spectrum library of the five drugs, and the dactylogram library is used for quickly detecting whether the unknown objects are the drugor not. Far-infrared wave photons are low in energy and high in penetrating power, and do not cause harm to a human body, and nondestructive detection can be realized.

The invention discloses a drug forbidding device based on a VR technology. The drug forbidding device comprises terminal equipment and a drug forbidding experience table, the terminal device is connected with the drug forbidding experience table and the personal VR all-in-one machine through the 5G module. The drug forbidding experience platform comprises a construction site module, VR experienceequipment and management equipment. The terminal equipment comprises a setting module, an open platform and a user-defined module. The open platform is four-in-one software used for drug forbidding. Adatabase module is arranged on the open platform; the database module comprises a case module, a drug cognition module, a deep experience module, a drug general law module and a drug hazard module; the drug hazard module comprises a personal hazard module, a family hazard module and a social hazard module; the drug forbidding device has the beneficial effects that the VR all-in-one machine or thepersonal VR all-in-one machine on the drug forbidding experience platform is connected with the terminal equipment and is used for enabling an experiencer to comprehensively recognize drugs, so thatthe experiencer can comprehensively recognize the drugs and harm of the drugs to a human body and vividly restore the drugs, the experiencer simulates a person on site, and the drug forbidding effectis improved.

The invention relates to the application of paralest in the opium drug detoxification abstinence treatment and belongs to the technical field of addiction medicine application. According to the functional characteristics of paralest of selectively breaking the cholinergic nerve tract of striaturn, inhibiting the hyperfunction of acetylcholine, correspondingly improving the effect of brain dopamine, being good for keeping or recovering the balance of two transmitter systems of striaturn dopamine (DA) and acetylcholine (Ach) and causing no drug dependence after long time usage, the paralest is used for the treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome), etc. Experimentation on animals and clinical trial show that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The paralest can be widely applied to the opium drug abstinence treatment.