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Application of roxadustat in preparation of drug for preventing and/or treating narcotic or drug addiction

A drug and addiction technology, applied in the field of drug use, to achieve the effect of promoting regression, less adverse reactions, and good tolerance

Active Publication Date: 2021-05-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, pharmacological experiments have proved that roxadustat has therapeutic or protective effects on peripheral diseases such as muscle damage, obesity-related inflammation, and metabolic diseases, as well as central nervous and psychiatric diseases such as spinal cord injuries, Parkinson's disease, and depression. Effects of drug or drug addiction or dependence not reported

Method used

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  • Application of roxadustat in preparation of drug for preventing and/or treating narcotic or drug addiction
  • Application of roxadustat in preparation of drug for preventing and/or treating narcotic or drug addiction
  • Application of roxadustat in preparation of drug for preventing and/or treating narcotic or drug addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preventive effect of roxadustat on methamphetamine addiction

[0036] The C57BL / 6J mice used in the present invention were purchased from Shanghai Slack Experimental Animal Co., Ltd., and the roxadustat used in the present invention was purchased from Selleck Company.

[0037] The mouse administration method is as follows:

[0038] Thirty-six male C57BL / 6J mice (8 weeks old, weighing 22-25g) were fed in an SPF grade animal room, and after one week of adaptive feeding, they were randomly divided into control group (11 mice), methamphetamine group (10 mice) and Methamphetamine+roxadustat group (15 rats). The mice in the control group were intraperitoneally injected with normal saline, the mice in the methamphetamine group were intraperitoneally injected with methamphetamine (2 mg / kg / day), and the mice in the methamphetamine+roxadustat group were injected intraperitoneally with roxadustat (10 mg / kg). / day), 6 hours later, intraperitoneal injection of methamphet...

Embodiment 2

[0042] Example 2 Preventive effect of roxadustat on morphine addiction

[0043] The C57BL / 6J mice used in the present invention were purchased from Shanghai Slack Experimental Animal Co., Ltd., and the roxadustat used in the present invention was purchased from Selleck Company.

[0044] The mouse administration method is as follows:

[0045] Thirty-six male C57BL / 6J mice (8 weeks old, weighing 22-25g) were bred in an SPF grade animal room. After one week of adaptive feeding, they were randomly divided into control group (14 mice), morphine group (13 mice) and morphine + Roxadustat group (14 rats). The mice in the control group were intraperitoneally injected with normal saline, the mice in the morphine group were injected intraperitoneally with morphine (20 mg / kg / day), and the mice in the morphine+roxadustat group were injected intraperitoneally with roxadustat (10 mg / kg / day) for 6 hours Morphine (20 mg / kg / day) was injected intraperitoneally for 7 consecutive days.

[0046]...

Embodiment 3

[0049] Example 3 Roxadustat preventive effect on morphine addiction dose-effect relationship

[0050] The C57BL / 6J mice used in the present invention were purchased from Shanghai Slack Experimental Animal Co., Ltd., and the roxadustat used in the present invention was purchased from Selleck Company.

[0051] The mouse administration method is as follows:

[0052] Thirty-six male C57BL / 6J mice (8 weeks old, weighing 22-25g) were raised in an SPF grade animal room, and after one week of adaptive feeding, they were randomly divided into control group (8 mice), morphine group (15 mice), morphine + Roxadustat 2.5mg / kg group (14 rats), morphine+roxadustat 5mg / kg group (14 rats), morphine+roxadustat 10mg / kg group (13 rats), morphine+roxadustat 20mg / kg group (14 rats). The mice in the control group were intraperitoneally injected with normal saline, the mice in the morphine group were injected intraperitoneally with morphine (20 mg / kg / day), and the mice in the morphine+roxadustat gr...

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Abstract

The invention relates to application of roxadustat in preparation of a drug for preventing and / or treating narcotic or drug addiction. The invention discloses that the roxadustat can prevent formation of narcotic or drug addiction behavior after being applied, and can promote regression of the narcotic or drug addiction behavior, so that the prevention and treatment of narcotic or drug addiction or dependence are realized.

Description

technical field [0001] The invention relates to the technical field of drug use, in particular to the application of roxadustat in the preparation of drugs for preventing and / or treating drug or drug addiction. Background technique [0002] Drugs refer to natural, semi-synthetic or synthetic substances that can cause dependence, excite or inhibit the central nervous system of animals, cause hallucinations, or damage animals' motor functions, thoughts, behaviors, feelings, and emotions. Among them, natural drugs include opium, morphine, etc.; semi-synthetic drugs include cocaine, etc.; synthetic drugs include amphetamine, methamphetamine (ice), etc. Drug addiction is a chronic recurrent brain disease. It is a chronic disease caused by a series of changes in the morphology, structure and function of brain nerve cells caused by long-term drug abuse. aspects of the problem. Drug addiction not only endangers the health, but also causes a heavy burden to the family and society, ...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61P25/36A23L33/10A23L2/38
CPCA61K31/47A61P25/36A23L33/10A23L2/38A23V2002/00A23V2200/334
Inventor 镇学初颜鹏举马明
Owner SUZHOU UNIV
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