A purification method for preparing a codeine standard substance used for forensic scientific drug detection

Abstract

A purification method for preparing a codeine standard substance used for forensic scientific drug detection is disclosed. The method includes (1) detecting codeine purities of seized codeine samples, and selecting the codeine sample as a raw material for preparing the codeine standard substance; and (2) preparing the codeine standard substance by utilizing high performance liquid chromatography. The obtained codeine obtained by the method is validated by nuclear magnetic resonance, liquid chromatography-tandem mass spectrometry and infrared spectroscopy analysis, the purity value of the codeine obtained by the method is determined by liquid chromatography and gas chromatography, impurities not responding to chromatography are measured, and according to standard substance development requirements, stability, uniformity, the fixed value and total uncertainty estimation of the prepared codeine standard substance all meet related regulations, thus meeting excepted indexes.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing codeine standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measurement technology ...

AI Technical Summary

Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.

Moreover, the lack of domestic drug standard substances has become a major obstacle restricting my country from realizing the standardization of forensic scientific drug detection chemical measurement methods, traceability and mutual recognition of measurement results.

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