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Application of Teprenone in preparing drug for preventing and/or treating readdiction in opiates narcotics

A technology of teprenone and opioids, which is applied in the field of medicine to achieve significant curative effect, reduce economic burden and low price

Inactive Publication Date: 2015-09-23
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether teprenone can be used for the prevention or treatment of opioid drug relapse has not been reported

Method used

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  • Application of Teprenone in preparing drug for preventing and/or treating readdiction in opiates narcotics
  • Application of Teprenone in preparing drug for preventing and/or treating readdiction in opiates narcotics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Teprenone antagonizes morphine-induced conditioned place preference experiment

[0016] The small animal autonomous activity detection device was used to measure the mice, and the mice were divided into 4 groups, with 10 mice in each group. The control group (C) was intragastrically administered normal saline for 7 consecutive days; the morphine group (Mor) was intragastrically administered normal saline for 7 consecutive days; the GGA and morphine-GGA group (GGA+Mor) was intragastrically administered GGA (800 mg / kg) for 7 consecutive days . On the eighth day, the initial time of the conditioned place preference experiment was measured for 15 minutes. Then on the 9th, 11th, 13th, and 15th day respectively, group C received intraperitoneal injection of normal saline, GGA and GGA+Mor group received intragastric administration of GGA (800 mg / kg), Mor group and GGA+Mor group received intraperitoneal injection of morphine 20 mg / kg, on the 10th, 12th, 14th, an...

Embodiment 2

[0017] Example 2: Teprenone inhibits the increased expression of NR2B in the NAc region induced by morphine relapse

[0018] Tissue collection and storage: After the mice were sacrificed by cervical dislocation, the chest was opened, the venous vessel end of the right atrium was cut open, and the left ventricle was perfused with 1×PBS buffer solution at a flow rate of 20 rpm. Bai Hou stopped. Then the tissues in the NAc area were taken, divided into liquid nitrogen, quick-frozen, marked, and stored in a -80°C refrigerator.

[0019] Extraction of protein in brain tissue: Take out the tissue in the NAc area frozen in the -80 ℃ refrigerator, use tweezers to take out the tissue of the same part and the same size, put it into a glass grinder and grind it into dispersed cells, add an appropriate amount of cell lysis Then suck out the mixed solution and put it into a 1.5 ml eppendorf centrifuge tube, and then crack it in ice bath every 10 min for 50 min, centrifuge at 15000 rpm an...

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PUM

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Abstract

The invention discloses a novel application of teprenone, and particularly relates to an application in preparing a drug for preventing and / or treating readdiction in opiates narcotics, and relates to the technical field of medicine. The experiment result shows that after the teprenone is orally taken for 7 days, the conditioned place preference test is carried out on re-addiction mouse after the morphine addiction disappears; when GGA is previously orally taken, the mouse conditioned place preference caused by the readdiction in the morphine can be remarkably inhibited; the expression of NAc-zone NR2B induced by readdiction of morphine can be remarkably inhibited on the molecular level, and the teprenone can be used for preparing the drug for preventing and / or treating opiates narcotics.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a medical application of teprenone, in particular to the application of teprenone in the preparation of drugs for preventing and / or treating relapse of opioid drugs. Background technique [0002] Drug relapse is an international public hazard and a long-term worldwide problem. It has become one of the main enemies of human beings in the 21st century, and has attracted extensive attention from researchers from all over the world. Relapse refers to the reappearance of drug-seeking and drug-taking behaviors of drug addicts after a period of abstinence due to certain factors, which is an important feature of drug addiction. The impact of drug relapse involves many fields such as social culture, politics, and behavior, and can cause a series of social and public health problems, such as the main cause of human immunodeficiency virus (Human Immunodeficiency Virus, HIV) and hepatitis B v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/121A61P25/30A61P25/36
Inventor 白洁朱光洁周小爽贾金婧
Owner KUNMING UNIV OF SCI & TECH
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