Purification preparation method for cocaine hydrochloride standard substance for forensic science drug detection

Abstract

The invention discloses a purification preparation method for a cocaine hydrochloride standard substance for forensic science drug detection. The purification preparation method comprises the following steps: (1) detecting purity of cocaine in captured cocaine samples, and selecting a captured cocaine sample of which the cocaine mass fraction is greater than or equal to 60wt% as a raw material for purification preparation of a cocaine hydrochloride standard substance; (2) preparing the cocaine hydrochloride standard substance through high performance liquid chromatography. The cocaine hydrochloride prepared by using the purification preparation method is confirmed through magnetic resonance imaging, liquid chromatography-electrospray tandem mass spectrometry and infrared spectroscopic analysis, the purity of the cocaine hydrochloride is confirmed through liquid chromatography and gas chromatography, and impurities which do not respond to chromatography are tested; according to standard substance study requirements, the stability, the uniformity, the definite values and the total uncertainty of the cocaine hydrochloride standard substance all meet related standards, and expected indexes can be met.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing cocaine hydrochloride standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measureme...

AI Technical Summary

Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.

Moreover, the lack of domestic drug standard substances has become a major obstacle restricting my country from realizing the standardization of forensic scientific drug detection chemical measurement methods, traceability and mutual recognition of measurement results.

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