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Purification preparation method for cocaine hydrochloride standard substance for forensic science drug detection

A technology for cocaine hydrochloride and standard substance, which is applied in the field of purification and preparation of cocaine hydrochloride standard substance, can solve the problems of restricting traceability and mutual recognition, affecting the accuracy of quantitative results, lack of drug standard substances, etc., to ensure effectiveness and improve analysis and measurement. The effect of quality, effective mutual recognition

Inactive Publication Date: 2017-08-29
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.
Moreover, the lack of domestic drug standard substances has become a major obstacle restricting my country from realizing the standardization of forensic scientific drug detection chemical measurement methods, traceability and mutual recognition of measurement results.

Method used

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  • Purification preparation method for cocaine hydrochloride standard substance for forensic science drug detection
  • Purification preparation method for cocaine hydrochloride standard substance for forensic science drug detection
  • Purification preparation method for cocaine hydrochloride standard substance for forensic science drug detection

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Embodiment Construction

[0042] In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0043] This embodiment mainly uses the cocaine samples seized in the case to optimize and screen the experimental conditions for the separation and purification of cocaine hydrochloride standard substances by preparative liquid chromatography.

[0044] 1. Instruments, reagents and materials

[0045] 1.1 Main Instruments

[0046] Analytical high-performance liquid chromatography (Shimadzu, Japan), including: LC-20AD high-pressure infusion pump; SIL-10A autosampler; SPD-20A diode array detector; CTO-20A column thermostat. ...

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Abstract

The invention discloses a purification preparation method for a cocaine hydrochloride standard substance for forensic science drug detection. The purification preparation method comprises the following steps: (1) detecting purity of cocaine in captured cocaine samples, and selecting a captured cocaine sample of which the cocaine mass fraction is greater than or equal to 60wt% as a raw material for purification preparation of a cocaine hydrochloride standard substance; (2) preparing the cocaine hydrochloride standard substance through high performance liquid chromatography. The cocaine hydrochloride prepared by using the purification preparation method is confirmed through magnetic resonance imaging, liquid chromatography-electrospray tandem mass spectrometry and infrared spectroscopic analysis, the purity of the cocaine hydrochloride is confirmed through liquid chromatography and gas chromatography, and impurities which do not respond to chromatography are tested; according to standard substance study requirements, the stability, the uniformity, the definite values and the total uncertainty of the cocaine hydrochloride standard substance all meet related standards, and expected indexes can be met.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing cocaine hydrochloride standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measureme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34G01N30/06G01N30/74G01N30/86G01N30/89
CPCG01N1/34G01N30/06G01N30/74G01N30/8634G01N30/89
Inventor 郑珲高利生赵彦彪张春水赵阳常颖贺剑锋翟晚枫李彭刘克林钱振华郑晓雨杨虹贤
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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