The invention discloses a signature calibration method and a terminal device. The signature calibration method includes the steps of obtaining hardware information of the terminal device in the state that a system is safely started, and conducting calibration to find out whether a system software package is legal or not through the terminal device according to N pieces of signature information in the system software package and the hardware information of the terminal device, wherein the hardware information of the terminal device includes at least one of the type of a processor of the terminal device, information of a manufacturer and the type of the device or any combination of the type of the processor of the terminal device, information of the manufacturer and the type of the device, the N pieces of signature information is generated according to original data of the system software package and different types of hardware information, and N is larger than or equal to 2. Due to the fact that the N pieces of signature information is generated according to the original data of the system software package and the different types of hardware information, the signature calibration method and the terminal device can adapt to safe starting of various types of hardware, and when the hardware information such as the type of the processor, the information of the manufacturer and the type of the device changes, normal use such as starting of the device, updating of the device and maintaining of the device can not be influenced.