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57 results about "Piperazine salt" patented technology

Flame retardant composition with improved fluidity, flame retardant resin composition and molded products

ActiveUS20070176154A1Improve flame retardant performanceImproved powder property and hygroscopic propertyDyeing processMelamine phosphateAdditive ingredient
The invention provides a flame retardant composition comprising 1-99 weight parts of a salt of piperazine and an inorganic compound selected from among piperazine phosphate, piperazine pyrophosphate and piperazine polyphosphate, or a mixture of two or more of these piperazine salts (ingredient (A)), 99-1 weight parts of a salt of melamine and an inorganic compound selected from among melamine phosphate, melamine pyrophosphate and melamine polyphosphate, or a mixture of two or more of these melamine salts (ingredient (B) ) (wherein, the sum of ingredient (A) and ingredient (B) is 100 weight parts), 0-50 weight parts of an arbitrary ingredient (ingredient (C)), and 0.01-20 weight parts of a silicone oil having a viscosity at 25° C. of 5000 mm2 / s (ingredient (D)) which is added thereto. This flame retardant not only has superior flame retarding properties, but also has enhanced powder properties and anti-hygroscopic properties, and when it is added to a resin, there is little change of electrical resistance.
Owner:ADEKA CORP

Flame retardant composition having improved processability, flame-retardant synthetic resin composition, and shaped article thereof

InactiveUS20100249286A1Improve processing stabilityAbility to suppress occurrence of “die buildup”Fireproof paintsAlcoholCarboxylic acid
A flame retardant composition contains, with respect to a flame retardant composition containing 1 to 99 parts by mass of a salt of piperazine and an inorganic phosphorus compound (component (A)) selected from piperazine phosphate, piperazine pyrophosphate, piperazine polyphosphate, or a mixture of at least two of the piperazine salts, and 99 to 1 parts by mass of a salt of melamine and an inorganic phosphorus compound (component (B)) selected from melamine phosphate, melamine pyrophosphate, melamine polyphosphate, or a mixture of at least two of the melamine salts (wherein the total of the component (A) and the component (B) is 100 parts by mass): 0.01 to 10 parts by mass of silicone oil; and 0.01 to 20 parts by mass of a monoamide compound of a higher aliphatic carboxylic acid and / or a monoester compound produced by reacting a higher aliphatic carboxylic acid with a monovalent to trivalent alcohol compound.
Owner:ADEKA CORP

Sacubitril derivatives and medicine compositions, preparation methods and application thereof

The invention provides sacubitril derivatives and medicine compositions, preparation methods and application thereof and belongs to the fields of medicine compounds and preparation thereof. The sacubitril derivatives comprise sacubitril lithium salt, sacubitril kali salt, sacubitril magnesium salt, sacubitril calcium salt, sacubitril strontium salt, sacubitril zinc salt, sacubitril ferric salt, sacubitril ammonium salt, sacubitril diethylamine salt, sacubitril ethylenediamine salt, sacubitril piperazine salt, sacubitril N-(2-ethoxyl)-pyrrolidine salt, sacubitril choline salt, sacubitril cholamine salt, sacubitril diethanol amine salt, sacubitril triethanolamine salt, sacubitril tromethamine salt, sacubitril meglumine salt, sacubitril diisopropylamine salt, sacubitril tert-butylamine salt, sacubitril N, N'-bis-benzyl ethylenediamine salt, sacubitril L-lysine salt, sacubitril L-arginine salt or sacubitril L-histidine salt.
Owner:SICHUAN HAISCO PHARMA CO LTD

Flame retardant composition and flame-retardant synthetic resin composition

Disclosed is a flame retardant composition having excellent flame retardancy and processability, providing a flame-retardant synthetic resin composition including this flame retardant composition and having excellent flame retardancy and processability. Specifically, the following components are used in combination: as component (A), 20 to 50 parts by mass of at least one type of melamine salt selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate; as component (B), 50 to 80 parts by mass of at least one type of piperazine salt selected from the group consisting of piperazine orthophosphate, piperazine pyrophosphate, and piperazine polyphosphate (the total of component (A) and component (B) is 100 parts by mass); and as component (C), 0.01 to 20.0 parts by mass of a bicyclophosphoric ester compound represented by the following general formula (1). The details of formula (1) are as described in the Description.
Owner:ADEKA CORP

Piperazine salt and a process for the preparation thereof

The invention relates to novel trans N-{4-{2-[4-(2, 3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate and a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate, said process comprising the stepsa) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl) amino]-cyclohexyl}-acetic acid ester with sodium borohydride and aluminium trichloride to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethanol;b) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]cyclohexyl}-ethanol obtained with methanesulfonic acid chloride in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate;c) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate obtained with 2,3-dichlorophenyl-piperazine in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester;d) heating trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester obtained to a temperature between 40-100° C. in a mixture of aqueous hydrochloric acid / methanol to give trans N-{4-{2-[4-(2,3-dichlorophenyl) piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate.
Owner:RICHTER GEDEON NYRT

Ionic liquid of N-methyl piperazine salt and preparation method thereof

The invention discloses ionic liquid of N-methyl piperazine salt. The ionic liquid has the structural general formula shown as the specifications. The invention also discloses a preparation method for the ionic liquid. N-methyl piperazine and Y acid are subjected to one-step reaction to directly form the ionic liquid of N-methyl piperazine salt. The method has the advantages of simple operation, wild reaction condition, high yield and product purity, simple storage and transportation, and suitability for industrial production; and in the produced ionic liquid of N-methyl piperazine salt, anions have plenty of selection spaces and structure and performance design spaces, and the ionic liquid can be applied to multiple fields.
Owner:ZHEJIANG UNIV

Flame-retardant composition and flame-retardant synthetic resin composition

Disclosed is a flame retardant composition that has excellent heat resistance and in which the risk of corroding processing machines at the time of compounding resin is reduced. The flame retardant composition includes 20 to 50 parts by mass of component (A) described below, 50 to 80 parts by mass of component (B) described below (the total of the component (A) and the component (B) is 100 parts by mass), and 0.01 to 5 parts by mass of component (C) described below:component (A): at least one type of melamine salt selected from melamine orthophosphate, melamine pyrophosphate, melamine polyphosphate, or a mixture including two or more types of the melamine salts;component (B): at least one type of piperazine salt selected from piperazine orthophosphate, piperazine pyrophosphate, piperazine polyphosphate, or a mixture including two or more types of the piperazine salts; andcomponent (C): a hydrotalcite compound.
Owner:ADEKA CORP

Salts with CRTH2 antagonist activity

The potassium, sodium, ammonium, lysine, diethylamine, tromethamine (TRIS), piperazine, ethylenediamine and ethanolamine salt of a compound of general formula (I): wherein R<1> is halo or cyano; R<2> is C1-C4 alkyl; and R<3> is quinolyl or phenyl substituted with methane sulfonyl; can be synthesised by a novel method and are substantially more soluble than the parent free acids in a range of solvents.
Owner:OXAGEN

Flame-retardant polypropylene composition

A disclosed flame-retardant polypropylene composition contains: a random copolymer polypropylene as a synthetic resin component; and a component (A) and a component (B) as flame retardant components, the component (A) being one or more melamine salts selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate, and the component (B) being one or more piperazine salts selected from the group consisting of piperazine orthophosphate, piperazine pyrophosphate, and piperazine polyphosphate. Furthermore, as a flame retardant component, the flame-retardant polypropylene composition preferably further contains zinc oxide as a component (C). Also, as a synthetic resin component, the flame-retardant polypropylene composition preferably further contains a styrene-based thermoplastic elastomer.
Owner:ADEKA CORP

Novel piperazine salts as d3/d2 antagonists

The present invention relates to novel monohydrochloride, dihydrochloride, monohydrobromide, maleate and methanesulphonate salts of trans 4-(2-(4-(2,3-dichlorophenyl)-piperazine-1-yl)-ethyl)-N,N-dimethylcarbamoyl-cyclohexylamine and / or their hydrates and / or solvates. Moreover, the invention relates to the process for preparing the salts and their hydrates and / or solvates, to their use in the treatment and / or prevention of conditions which require modulation of dopamine receptor and to pharmaceutical compositions containing them.
Owner:RICHTER GEDEON NYRT

Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine

InactiveUS20080161566A1Excellent cell adhesion inhibitory actionOrganic active ingredientsNervous disorderUlcerative colitisAutoimmune disease
Salts and crystals of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine have excellent cell adhesion inhibitory action and cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis.
Owner:EISIA R&D MANAGEMENT CO LTD

Composition, and flame-retardant resin composition

A composition according to the present invention contains component (A), component (B), and component (C) below, wherein component (A)is at least one melamine salt selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate; component (B)is at least one piperazine salt selected from the group consisting of piperazine orthophosphate, piperazinepyrophosphate, and piperazine polyphosphate; and component (C)is a monohydrate of alumina. According to the present invention, a composition is provided, which, when mixed with a resin, can impart excellent processability and moldability and flame retardancy to the resin.
Owner:ADEKA CORP

Oleanolic acid piperazine salt and preparation method thereof

The invention discloses an oleanolic acid piperazine salt and a preparation method thereof. The oleanolic acid salt refers to oleanolic acid piperazine salt and has the chemical structure general formula described in the specification of the invention. The oleanolic acid piperazine salt has the advantages of good solubility, dissolving rate, low moisture absorption, high stability and higher bioavailability. Therefore, the invention provides a form of oleanolic acid salt with bright clinical practice prospect.
Owner:KAIHUI SCI & TECH DEV SHANGHAI

Method for preparing trimetazidine dihydrochloride

The invention discloses a method for preparing trimetazidine dihydrochloride. The method includes steps of (1), dissolving piperazine into solvents and adding acid into the solvents to obtain piperazine salt; (2), adding 2, 3, 4-trimethoxy benzaldehyde, cetyl trimethyl ammonium bromide and nickel catalysts into the product obtained at the step (1) and carrying out catalytic hydrogenation reaction; (3), separating reaction products to obtain oily substances after the reaction is completely carried out, acidifying the oily substances by the aid of hydrochloric acid and crystallizing the oily substances to obtain the trimetazidine dihydrochloride. The method has the advantage of mild and safe reaction conditions and simplicity and convenience in operation. Besides, the usage of the piperazine can be reduced, the trimetazidine dihydrochloride prepared by the aid of the method is high in purity and yield, and the production cost can be reduced.
Owner:SUZHOU JINGYE MEDICINE & CHEM

Piperazine salt and a process for the preparation thereof

The invention relates to novel trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate and a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate, said process comprising the stepsa) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)amino]-cyclohexyl}-acetic acid ester with sodium borohydride and aluminum trichloride to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethanol;b) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]cyclohexyl}-ethanol obtained with methanesulfonic acid chloride in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate;c) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate obtained with 2,3-dichlorophenyl-piperazine in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester;d) heating trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester obtained to a temperature between 40-100° C. in a mixture of aqueous hydrochloric acid / methanol to give trans N-{4-{2-[4-(2,3-dichlorophenyl)piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate.
Owner:RICHTER GEDEON NYRT

Montelukast benzhydryl piperazine salts and process for preparation thereof

The invention relates to Benzhydryl piperazine salts of [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid represented by the formula (III). Furthermore, the invention relates to the use of Benzhydryl piperazine salts of [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid represented by the formula (III) for the preparation of substantially pure [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropane acetic acid or its alkali salts and pharmaceutical composition comprising the same.
Owner:TORRENT PHARMA LTD

Flame-retardant composition and flame-retardant synthetic-resin composition

Disclosed is a flame-retardant synthetic resin composition containing: 20 to 50 parts by mass of at least one melamine salt selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate (component (A)); 50 to 80 parts by mass of at least one piperazine salt selected from the group consisting of piperazine orthophosphate, piperazine pyrophosphate, and piperazine polyphosphate (component (B)), provided that the sum of components (A) and (B) is 100 parts by mass; and 1 to 50 parts by mass of a compound represented by general formula (1) (component (C)):wherein R1 represents an aliphatic or aromatic monocarboxylic acid residue.
Owner:ADEKA CORP

Sulfasalazine salts, production processes and uses

Disclosed are a process for preparing new crystal salt forms of sulfasalazine, in particular crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine (see FIG. 1), crystal form A of the piperazine salt of sulfasalazine (see FIG. 2) and crystal Form B of the diethylamine salt of sulfasalazine (see FIG. 4), and a pharmaceutical composition containing one or more of the inventive crystal salt forms in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and / or the gastro-intestinal tract.
Owner:MEDAC GES FUR KLINISCHE SPEZIALPRAPAR MBH

Flame-retardant composition and flame-retardant synthetic-resin composition

A flame-retardant synthetic-resin composition which comprises 20-50 parts by mass of component (A) which is at least one melamine salt selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate, 50-80 parts by mass of component (B) which is at least one piperazine salt selected from the group consisting of piperazine orthophosphate, piperazinepyrophosphate, and piperazine polyphosphate (the sum of component (A) and component (B) is 100 parts by mass), and 1-50 parts by mass of component (C) which is a compound represented by formula (1).(R1 represents a residue of an aliphatic monocarboxylic acid or a residue of an aromatic monocarboxylic acid.)
Owner:ADEKA CORP

Novel process for preparing flibanserin

The invention discloses a novel process for preparing flibanserin. The process comprises the following steps: taking 1-benzyl or substituted benyl-2-benzimidazolone as a raw materials; reacting the raw material with 1,2-dibromoethane to generate an intermediate 1; reacting the intermediate 1 with 1-(3-trifluoromethyl-phenyl) piperazine salt to generate an intermediate 2; and adding hydrogen into the intermediate 2 to remove a protecting group in the presence of a catalyst to obtain the flibanserin. Raw materials in the method are low in price and are easily obtained, an operation method is simple, the reaction conditions are gentle, and the novel process for preparing the flibanserin has potential industrial value.
Owner:葵花药业集团北京药物研究院有限公司

Composition and flame-retardant resin composition

A composition includes first, second, and third components. The composition preferably includes 0.1 to 50 parts by mass of the third component with respect to 100 parts by mass in total of the first and second components. The first component is at least one type of melamine salt selected from the group consisting of melamine orthophosphate, melamine pyrophosphate, and melamine polyphosphate. The second component is at least one type of piperazine salt selected from the group consisting of piperazine orthophosphate, piperazine pyrophosphate, and piperazine polyphosphate. The third component is cyanuric acid or zinc cyanurate.
Owner:ADEKA CORP
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