54 results about "Oa osteoarthritis" patented technology

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention provides a stem cell injection for treating osteoarthritis cartilage defect and preparation and application thereof. The injection comprises fifth-generation umbilical cord mesenchymal stem cells and a liquid solvent, wherein the fifth generation umbilical cord mesenchymal stem cells are suspended in the liquid solvent, and the concentration is (2.0-3.0)x10<7> cells / 4.5-5.0ml of the liquid solvent. The liquid solvent is normal saline, or autologous platelet-rich plasma, or a mixed solution of normal saline and human albumin, or a mixed solution of normal saline and autologous platelet-rich plasma. The human albumin accounts for 5-8% in volume by percentage. The normal saline accounts for 10% or below in volume by percentage. The injection is administered by intravenous injection or bone joint cavity local injection or the combination of the two, the cell injection amount of the intravenous injection is (1.0-1.5)x10<8> cells / one time, and the cell injection amount of the bone joint cavity injection is (2.0-3.0)x10<7> cells / one time / one knee. The effect of the stem cell injection for treating the integrity degree of osteoarthritis cartilage is obviously superior to that of a traditional hyaluronic acid (HA) method.

The invention provides a knee osteoarthritis exercise rehabilitation instrument. The knee osteoarthritis exercise rehabilitation instrument comprises a deck chair, a resistance arm installed on the deck chair through a pivot, a flywheel in transmission connection with the resistance arm, an electromagnetic resistance device arranged close to the flywheel and a control device electrically connectedwith the electromagnetic resistance device. The electromagnetic resistance device comprises a magnet and a resistance adjusting unit connected with the magnet, the control device is configured to control the resistance adjusting unit so as to adjust the rotating resistance of the flywheel, and an anti-resistance device is further arranged on the reclining chair and is in transmission connection with the pivoting end of the resistance arm so that the anti-resistance device and the resistance arm can synchronously and reversely move. Therefore, the pressure in the joint capsule during movementis increased. Due to the fact that the resistance-adjustable electromagnetic resistance device is arranged, a user can select the most appropriate exercise mode by himself / herself.

The invention discloses a traditional Chinese medicine plaster for treating neck-shoulder and lumbocrural pain. The traditional Chinese medicine plaster is prepared from the following active pharmaceutical ingredients: radix angelicae lateralis preparata, radix paeoniae rubra, safflower, sangusis draconis, catechu, olibanum, myrrha, radix gentianae macrophyllae, semen strychni, radix saposhnikoviae and radix glycyrrhizae. The traditional Chinese medicine plaster is reasonable in formula, significant in efficacy, low in price, has a good effect on relieving pain caused by various reasons, is especially applicable to pain caused by cervical spondylosis, lumbar muscle degeneration, psoatic strain, rheumatism rheumatoid arthritis, uarthritis, joint sprains, degenerative osteoarthritis and the like, and has no obvious adverse effects.

The invention discloses a traditional Chinese medicine lotion for treating osteoarthritis and application method thereof. The lotion is prepared from the following components: Chinese prickly ash, caulis sinomenii, safflower, dahurian angelica root, notopterygium root, angelica pubescens, clematis root, spatholobus stem, raw radix aconiti, saposhnicovia divaricata, Chinese angelica, asarum herb, ligusticum wallichii, frankincense, myrrh, buck grass, cassia twig, and licorice. The invention also discloses an application method of the lotion. The invention also discloses an application of the lotion in treating calcaneal spur. The invention also discloses a method using the lotion to treat calcaneal spur. The lotion can relieve the pain caused by osteoarthritis, improves the functions of bones and life quality of patients, and avoids the risk of surgery of artificial joint replacement and pricy treatment cost.

The invention relates to novel self-assembling peptide complexes comprising a charged peptide and a polysaccharide, methods of producing them and uses therefor. The novel self-assembling peptide complexes of the present invention have particular utility in the restoration of biomechanical or biochemical function of a variety of biological tissues, for example and without limitation, in degenerated spinal discs, osteoarthritic joints, damaged cartilage, meniscus, ligaments, tendons, dental, ophthalmic and cardiovascular and blood vessel tissues. The invention provides inter alia methods of repairing and or restoring biomechanical or biochemical function of biological tissues and scaffolds for the support of cell growth.

The invention provides a preparation method of a targeting chondrocyte exosome. The preparation method comprises the following steps of preparing an exosome carrier, preparing a targeting cartilage exosome, and preparing miRNA-140 wrapped by the targeting cartilage exosome. The preparation method has the beneficial effects that the miRNA medicine is delivered with treatment potential, high efficiency and tissue specificity for treating osteoarthritis, the application of the miRNA-140 wrapped by the targeting exosome in the medicine for treating osteoarthritis is mainly utilized, in an osteoarthritis animal model of a rat, the expression of MMP-13 can be inhibited by injecting the miRNA-140 into a knee joint cavity, the damage of cartilage matrix can be obviously improved, the cartilage damage process of an osteoarthritis animal model is delayed, and the cartilage protection effect is achieved, and therefore, the exosome is used for transporting miRNA-140 in a targeted manner, degradation of cartilage tissues can be slowed down, and the effect of inhibiting catabolism of cartilage matrix is achieved, so that the damage of articular cartilage is controlled, and cartilage repair is promoted.

Disclosed are pharmaceutical compositions containing, as the active ingredients, a mixture of a hyaluronic acid polymer with a bradykinin B2 receptor antagonist. Said compositions have proved especially effective in the treatment of degenerative joint diseases such as osteoarthritis using intra-articular injections.

The invention discloses a medicine preparation form, especially discloses a Bulleyaconitin A dry emulsion and the preparing method and application. It takes Bulleyaconitin A in the dry emulsion as effective component, and also comprises oil phase, emulsifying agent and other findings. The dry emulsion is characterized by mature preparation process, easy industrialization, good stability, easy transportation and storage, controllable medicine content and good effect. The invention is used for local anesthesia, reducing fever, relieving pain, treating rheumatism and atrophic arthritis, scapulohumeral periarthritis, sprain of waist and limbs joints, herpes zoster, cold and dentalgia and other infections or pains.

Disclosed are pharmaceutical compositions containing, as the active ingredients, a mixture of a hyaluronic acid polymer with a bradykinin B2 receptor antagonist. Said compositions have proved especially effective in the treatment of degenerative joint diseases such as osteoarthritis using intra-articular injections.

Disclosed herein is Synergistic herbal composition(s) comprising combination of a first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Murraya koenigii and a second ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Coriandrum sativum or Curcuma amada for improving cartilage growth / repair / regeneration, improving joint mobility, reducing cartilage breakdown, reducing joint pain, reducing stiffness, reducing inflammation and / or treating / alleviating symptoms associated with osteoarthritis. The invention further provides method of improving cartilage growth / repair / regeneration, improving joint mobility, reducing cartilage breakdown, reducing joint pain, reducing stiffness, reducing inflammation and / or treating / alleviating symptoms associated with osteoarthritis in a human or animal.

The invention provides a traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from from the following raw material medicines in parts by weight: 10-20 parts of poria cocos, 5-15 parts of cassia twigs, 2-8 parts of rhizoma atractylodis, 2-8 parts of cortex phellodendri, 2-8 parts of radix stephaniae tetrandrae, 2-8 parts of polyporus umbellatus, 2-8 parts of rhizoma drynariae, 5-15 parts of rhizoma corydalis and 3-9 parts of radix cyathulae. The composition disclosed by the invention has the functions of tonifying spleen, promoting diuresis, dispelling wind, clearing heat, dredging collaterals and relieving pain, and is clinically applicable to patients suffering from rheumatic fever arthralgia in the attack stage of knee osteoarthritis, wherein the patients have the symptoms of swelling, pain, unfavorable flexion and extension and even local pyrexia, redness and swelling of joints, fat and big tongue body with tooth prints, yellow and greasy tongue coating and few pulse strings. When the composition provided by the invention is used for intervening in a rabbit with knee osteoarthritis, results show that the composition can relieve symptoms like joint swelling and skin temperature rise of the rabbit with knee osteoarthritis, improve joint functions, reduce the contents of IL-1[beta], TNF[alpha], PGE2 and NO in joints, relieve synovitis and delay the progress of knee osteoarthritis. Clinical observation results show that the composition provided by the invention has theeffects of relieving swelling and pain and improving joint functions for patients with knee osteoarthritis.

The present invention relates to a composition for treating osteoarthritis and a method for preparing the same, and more specifically, relates to a composition comprising hydrophilized sulfasalazine as an active ingredient and hyaluronic acid so as to enable effective treatment of osteoarthritis such as degenerative osteoarthritis by preventing joint wear in addition to symptom relief through intraarticular or local administration, and a method for preparing the same. When such a composition for osteoarthritis treatment is prepared by the preparation method according to the present invention, the dissolved state is maintained beyond a neutralization step after dissolution, preventing precipitation of sulfalazine by salting out occurring after neutralization, and thus a composition comprising high concentration of sulfasalazine can be prepared, and the composition prepared accordingly is highly effective in treating osteoarthritis, particularly degenerative osteoarthritis, through the intraarticular or local administration, since it comprises high concentration of sulfasalazine which had to be formulated at low concentration by conventional method due to poor solubility.

The invention discloses a multifunctional nano graphene oxide (NGO) compound for treating osteoarthritis (OA), which is mainly composed of biocompatible functional NGO PEG-BPEI-NGO (PPG) and KGN, NGOis functionally modified by amino-terminated polyethylene glycol (PEG) and branched polyethyleneimine (BPEI), the biocompatible functional NGO product PEG-BPEI-NGO (PPG) is synthesized, non-covalent loading of hydrophobic KGN molecules (PPG-KGN) is carried out through pi-pi accumulation and hydrophobic action, MSCs and PPG-KGN are co-incubated before articular cavity injection, and the intracellular transport efficiency of KGN can be improved through PPG-KGN to obtain KGN enhanced MSCs (BMSCs (PPG-KNG)). The BMSCs (PPG-KNG) has higher chondrogenic differentiation characteristic, can effectively inhibit the development of osteoarthritis, relieve joint gap stenosis and subchondral osteosclerosis, improve osteoarthritis pain and promote tissue regeneration, can better assist stem cell treatment, and provides conditions for relieving osteoarthritis symptoms and improving pathophysiology.

The invention relates to the industries of functional food, cosmetics and medicine, and in particular, relates to glucosamine hyaluronate and an application thereof. The structural formula of the glucosamine hyaluronate is represented by a formula (1), and the average polymerization degree n is 10-1000. The prepared glucosamine hyaluronate has a good treatment effect on osteoarthritis model rats in an articular cavity injection mode, and can be used for but not limited to the field of daily chemicals especially moisture absorption and preservation agents of cosmetics, wrinkle removal filling injection for beauty, anti-fatigue eye drops and related joint treatment or auxiliary health care.

The invention discloses an externally-applied glucosamine chondroitin nano-preparation and a preparation method thereof. The externally-applied glucosamine chondroitin nano-preparation comprises a nano-liposome and an inner material, the inner material comprises the following components in percentage by mass: 4-6% of glycerol, 3-6% of propylene glycol, 5-12% of N-acetyl-D-glucosamine, 2-4% of a humectant, 8-10% of a penetration enhancer, 2-8% of shark bone chondroitin sulfate, 1-3% of bovine bone chondroitin, 8-12% of a lipid material, 2-6% of stearyl alcohol, 2-6% of cetyl alcohol, 8-10% of mineral oil, 2-4% of silicone oil, 2-4% of an emulsifier, 1.2-1.6% of a preservative and the balance of deionized water. The particle size is smaller, the transdermal rate is high, the usage amount of effective components is small, the production cost is saved, and glucosamine and chondroitin can rapidly permeate into joints to lubricate the joints, relieve osteoarthritis pain and inflammation and repair cartilage tissue.

The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

Provided are liposomes that encapsulate adenosine. The liposomes may be formed from sphingomyelin or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG, and DMPC. The liposomes encapsulating adenosine may be used to induce cartilage regeneration, treat osteoarthritis, alleviate joint pain, and / or slow, arrest, and / or reverse progressive structural tissue damage associated with osteoarthritis or treat osteoarthritis, rheumatoid arthritis, acute gouty arthritis, and / or synovitis. The liposomes may release adenosine for up to two weeks.

The invention discloses a treatment model for osteoarthritis by human adipose-derived stem cells and a treatment method thereof. The treatment method of the model comprises the following steps: P1, preparing a stem cell injection; P2, establishing an osteoarthritis model; P3, performing model separation; P4, performing interventional therapy; P5, performing tissue observation; P6, performing result statistics; and P7, performing contrast. The invention provides the treatment model for osteoarthritis by human adipose-derived stem cells and the treatment method thereof, the tubular joint induction is carried out on an experimental white mouse, the joint tube disease position and deterioration degree can be effectively controlled, meanwhile, two different forms of local injection treatment and intravenous injection treatment are combined, the intervention result is compared and analyzed, the change process and the intervention direction can be easily controlled, meanwhile, the intervention result is archived and compared and analyzed, the optimal solution can be easily obtained, the stem cell effect and differentiation effect are improved, the treatment effect is improved, and control, use and popularization are facilitated.

The invention relates to a purpose of a Chinese herba preparation in treating osteoarthritis in an external use paster. The Chinese herba preparation comprises, by weight, 10-20 parts of radix angelicae pubescentis, 10-20 parts of dandelion, 10-20 parts of erodium stephanianum willd, 10-20 parts of goldthread, 10-20 parts of cactuses, 10-20 parts of bark of Chinese redbud, 5-10 parts of centipeda minima, 5-10 parts of golden cypress, 5-10 parts of toad, 5-10 parts of rhizoma calami, 5-10 parts of the root bark of white mulberry, 5-10 parts of corydalis tuber, 10-15 parts of notopterygium roots, 10-15 parts of spina gleditsiae, 10-15 parts of aloes, 10-15 parts of fructus cnidii, 15-20 parts of ramulus mori, 15-20 parts of fructus evodiae, 15-20 parts of ligusticum wallichii, 15-20 parts of rattletop, 15-20 parts of radix aconiti preparata and 15-20 parts of liquorice. The compatibility of the osteoarthritis paster conforms to the traditional Chinese medicine assistant and guide principle, the components are scientific and reasonable, the drugs are in transdermal absorption, the drug efficacy can go straight to the affected part during treatment, the joint pressing pain and bump can be rapidly relieved, and the osteoarthritis paster has the advantages of being fast in effect taking, free of toxic and side effect, low in cost and the like; meanwhile, the relapse cannot happen after treatment, the satisfied short-term curative effect is achieved, and a good long-term curative effect is also achieved.

The invention relates to a composition for relieving osteoarthritis pain and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition for relieving the osteoarthritis pain comprises the following components in parts by weight: 25-85 parts of a procumbent pseudo-ginseng and chrysanthemum extract, 10-35 parts of a vinegar-processed curcuma zedoary extract and 5-25 parts of a fried szechwan chinaberry fruit extract. The composition for relieving the osteoarthritis pain contains the procumbent pseudo-ginseng and chrysanthemum extract, and has various pharmacological effects of resisting inflammation, resisting infection and the like; the curcuma zedoary extract has the effects of promoting qi circulation, breaking blood, removing food retention and relieving pain; the szechwan chinaberry fruit has the effects of soothing liver and relieving heat, promoting qi circulation and relieving pain and killing insects; and a large number of studies find that the procumbent pseudo-ginseng and chrysanthemum extract, the curcuma zedoary extract and the szechwan chinaberry fruit extract in the composition have a synergistic effect, and the composition has the remarkable effects of promoting qi to activate blood and activating meridians to stop pain on relieving slight or moderate pain of osteoarthritis and pain such as traumatic injuries, sprains, muscular pain and fractures.

Provided is a nanobody or a multivalent nanobody that binds to a β-NGF antigen, which can be used for treating, preventing, detecting or diagnosing diseases associated with β-NGF, such as pain or inflammation, especially postoperative pain, rheumatoid arthritis Pain and Osteoarthritis Pain.

The present invention relates to a composition for treating osteoarthritis and a method for preparing the same, and more specifically, relates to a composition comprising hydrophilized sulfasalazine as an active ingredient and hyaluronic acid so as to enable effective treatment of osteoarthritis such as degenerative osteoarthritis by preventing joint wear in addition to symptom relief through intraarticular or local administration, and a method for preparing the same. When such a composition for osteoarthritis treatment is prepared by the preparation method according to the present invention, the dissolved state is maintained beyond a neutralization step after dissolution, preventing precipitation of sulfalazine by salting out occurring after neutralization, and thus a composition comprising high concentration of sulfasalazine can be prepared, and the composition prepared accordingly is highly effective in treating osteoarthritis, particularly degenerative osteoarthritis, through the intraarticular or local administration, since it comprises high concentration of sulfasalazine which had to be formulated at low concentration by conventional method due to poor solubility.