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Multifunctional nano graphene oxide (NGO) compound for treating osteoarthritis (OA)

A technology of nano-graphite oxide and osteoarthritis, applied in bone diseases, drug combinations, medical preparations of non-active ingredients, etc., can solve the problems of poor bioavailability, difficult intracellular delivery, etc., to inhibit development and improve Chondrogenic differentiation potential, effect of alleviating pathophysiology

Inactive Publication Date: 2021-02-02
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, KGN is not easily soluble in water, so it is difficult to carry out effective intracellular delivery and has poor bioavailability

Method used

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Embodiment Construction

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0031] In the embodiment of the present invention, the multifunctional nano-graphene oxide composite for treating osteoarthritis, the multifunctional nano-graphene oxide composite is mainly composed of the following components: graphene oxide (GO), amino-terminated polyethylene Diol (PEG), branched polyethyleneimine (BPEI), N-(3-dimethylaminopropyl-N′-ethylcarbodiimide) hydrochloride (EDC·HCl) and N-hydroxy Succinimide (NHS), KGN.

[0032] The preparation process of the multifunctional nano-graphene oxide composite for the treatment ...

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PUM

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Abstract

The invention discloses a multifunctional nano graphene oxide (NGO) compound for treating osteoarthritis (OA), which is mainly composed of biocompatible functional NGO PEG-BPEI-NGO (PPG) and KGN, NGOis functionally modified by amino-terminated polyethylene glycol (PEG) and branched polyethyleneimine (BPEI), the biocompatible functional NGO product PEG-BPEI-NGO (PPG) is synthesized, non-covalent loading of hydrophobic KGN molecules (PPG-KGN) is carried out through pi-pi accumulation and hydrophobic action, MSCs and PPG-KGN are co-incubated before articular cavity injection, and the intracellular transport efficiency of KGN can be improved through PPG-KGN to obtain KGN enhanced MSCs (BMSCs (PPG-KNG)). The BMSCs (PPG-KNG) has higher chondrogenic differentiation characteristic, can effectively inhibit the development of osteoarthritis, relieve joint gap stenosis and subchondral osteosclerosis, improve osteoarthritis pain and promote tissue regeneration, can better assist stem cell treatment, and provides conditions for relieving osteoarthritis symptoms and improving pathophysiology.

Description

technical field [0001] The invention relates to the technical field of osteoarthritis treatment, in particular to a multifunctional nanometer graphene oxide compound for treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) is the most common degenerative bone and joint disease, leading to severe pain, dysfunction in affected joints, and an increased public health burden. Its pathological features are: intra-articular inflammation and catabolism imbalance, leading to progressive degeneration of multiple joints. A good OA treatment strategy usually needs to simultaneously reduce the inflammatory response and promote the regeneration of cartilage tissue. Due to the poor self-regeneration and repair ability of cartilage tissue, there is currently no effective treatment strategy for OA. The current conservative treatment methods for osteoarthritis include weight loss, exercise, physical therapy, the use of painkillers, nutritional cartilage drugs, anti-inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K35/28A61K47/04A61P19/02A61P19/08
CPCA61K31/192A61K35/28A61K47/02A61P19/02A61P19/08A61K2300/00
Inventor 曾伟南周宗科余秋萍王端于浩达
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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