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Bulleyaconitin A dry emulsion and its preparation method and application

A technology of sulfamethoxine and dry emulsion, which is applied in the field of pharmaceutical dosage forms in the field of medical technology, can solve problems such as the destruction of drugs and auxiliary materials, the large volume of fat emulsion infusion, the breaking of emulsion droplets, etc. The effect of controllable content and mature production process

Inactive Publication Date: 2007-10-24
陈云生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fat emulsion infusion has a large volume, which is inconvenient for production, storage, transportation, and clinical application; emulsion droplets are easy to aggregate; high-temperature sterilization will cause damage to drugs and auxiliary materials; Diffusion and phospholipids in a solution state are prone to oxidation reactions, etc.; the water in the infusion is easy to freeze, which easily leads to demulsification of emulsion droplets; this makes the storage validity period of aconitin fat emulsion infusion short

Method used

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  • Bulleyaconitin A dry emulsion and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1) In the preparation equipment, dissolve 0.005 g of aconitin in 300 ml of safflower oil;

[0047] 2) Mix 10g of lecithin with an appropriate amount of water for injection, and add 50gV c ;

[0048] 3) Add 2) into 1) under the condition of stirring, and after stirring at 20° C., pass through a homogenizer to homogenize the solution repeatedly to obtain a uniform solution. Prepare a total of 2000ml of liquid medicine;

[0049] 4) Add 80% mannitol as a protective agent, remove moisture through spray drying, and obtain dry aconitin dry emulsion;

[0050] 5) Add water to the prepared dry emulsion according to the required amount, revert to emulsion after hydration and shaking.

Embodiment 2

[0052] 1) In the preparation equipment, dissolve 0.4 g of aconitin in 25 ml of safflower oil for injection;

[0053] 2) Mix 9g of lecithin with an appropriate amount of water for injection, and add 1g of sodium oleate;

[0054] 3) Add 2) into 1) under the condition of stirring, and after stirring at 30° C., pass through a homogenizer to homogenize the solution repeatedly to obtain a uniform solution. Prepare a total of 1000ml of liquid medicine;

[0055] 4) adding 12% glucose as a protective agent, and removing moisture by freeze-drying to obtain a dry curicaconin dry emulsion;

[0056] 5) Add water to the prepared dry emulsion according to the required amount, revert to emulsion after hydration and shaking.

Embodiment 3

[0058] 1) In the preparation equipment, dissolve 8 g of aconitin in acetone, and then evenly disperse the acetone solution in 1000 ml of olive oil;

[0059] 2) Mix 5g of poloxamer, 0.1g of natural stevioside with water, and add 40g of ethylparaben

[0060] 3) Add 2) to 1) under the condition of stirring, and after stirring at 80° C., pass through a homogenizer to homogenize the solution repeatedly to obtain a uniform solution. Prepare the liquid medicine of 4000ml;

[0061] 4) adding 40% maltose as a protective agent, distilling off the water under reduced pressure, and adding silicon dioxide to absorb excess water to obtain a dried aconitin dry emulsion;

[0062] 5) Add water to the prepared dry emulsion according to the required amount, revert to emulsion after hydration and shaking.

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Abstract

The invention discloses a medicine preparation form, especially discloses a Bulleyaconitin A dry emulsion and the preparing method and application. It takes Bulleyaconitin A in the dry emulsion as effective component, and also comprises oil phase, emulsifying agent and other findings. The dry emulsion is characterized by mature preparation process, easy industrialization, good stability, easy transportation and storage, controllable medicine content and good effect. The invention is used for local anesthesia, reducing fever, relieving pain, treating rheumatism and atrophic arthritis, scapulohumeral periarthritis, sprain of waist and limbs joints, herpes zoster, cold and dentalgia and other infections or pains.

Description

Technical field: [0001] The invention relates to pharmaceutical dosage forms in the technical field of medicine, in particular to a dry emulsion of aconitin and its preparation method and application. Background technique: [0002] Bulleyaconitioue A, molecular formula C 35 h 49 o 10 N, molecular weight 643.77, is a colorless prismatic crystal. This product is soluble in ether, alcohol, acid water, insoluble in water and easy to decompose, has strong analgesic and obvious anti-inflammatory effects. Experiments have proved that the analgesic effect of this product is central and closely related to the level of serotonin in the brain. Non-addictive; its anti-inflammatory effect does not pass through the adrenal system, but is related to the suppression of PG levels; this product also has antipyretic and local anesthetic effects. Aconitin has the highest content in the liver and adrenal gland, followed by the kidney, lung, spleen and heart, and the brain content is very lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K9/107A61P23/02A61P29/00A61P19/00
Inventor 贾奕陈云生
Owner 陈云生
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