Pharmaceutical compositions containing bradykinin antagonists and hyaluronic acid, and uses thereof

Abstract

Disclosed are pharmaceutical compositions containing, as the active ingredients, a mixture of a hyaluronic acid polymer with a bradykinin B2 receptor antagonist. Said compositions have proved especially effective in the treatment of degenerative joint diseases such as osteoarthritis using intra-articular injections.

Description

Field of Invention [0001] The present invention relates to pharmaceutical compositions comprising, as active ingredients, a mixture of a hyaluronic acid polymer and a bradykinin B2 receptor antagonist. The compositions have proven particularly effective for intra-articular injections in the treatment of degenerative joint diseases such as osteoarthritis. Background technique [0002] Osteoarthritis (OA), also known as degenerative joint disease, is a painful, progressive, degenerative condition of the joints. The main pathophysiological features of OA are articular cartilage destruction and defect, hypertrophy, synovial inflammation and subsequent joint swelling. These effects produce symptoms such as pain, stiffness, and loss of function. As life expectancy increases, the high incidence of OA in the aging population suggests that there may be a considerable increase in the number of patients with the condition in the near future. People with OA consider pain reduction ve...

AI Technical Summary

Problems solved by technology

[0022] However, there remains an unmet need for effective treatments for degenerative joint diseases such as osteoarthritis

Images