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Composition for relieving osteoarthritis pain and application thereof

A technique for osteoarthritis pain and a composition, which is applied in the field of compositions for relieving osteoarthritis pain, can solve the problems of restricting patient compliance, unsatisfactory coating effect, cumbersome use method, etc., and achieves easy temperature control and properties. Good and practical effect

Inactive Publication Date: 2021-12-03
完美(广东)日用品有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine fumigation and compound external application have complicated medicinal taste and cumbersome application methods, which greatly limit its clinical use and patient compliance.
Common external preparations such as ointment, liniment and patch also have different limitations.
For example, a thickening agent with a viscosity of less than 5000cps is not ideal for applying to the skin of the diseased part, and it is not suitable for use if the viscosity exceeds 35000cps; traditional ointments need to touch the ointment with hands to apply the drug on the affected part, but applying the ointment by hand may Risk of contacting the eyes and other mucous membranes with the drug

Method used

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  • Composition for relieving osteoarthritis pain and application thereof
  • Composition for relieving osteoarthritis pain and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The extraction method of the Panax notoginseng extract of the embodiment of the present invention: Weigh 20kg of the Panax notoginseng dry ground whole plant, cut into sections of 4-10cm, add 10 times the volume fraction to 60% ethanol aqueous solution, 100°C Extract under heat reflux for 3 hours, repeat 3 times, concentrate and recover the solvent at 100°C, and obtain 5.1831kg of the extract of Pingbu notoginseng; 20 macroporous adsorption resin adsorption, first eluted with 120L 10% ethanol aqueous solution, and recovered the solvent under reduced pressure to obtain 2.77kg of eluate, then eluted with 120L 50% ethanol aqueous solution, recovered the solvent under reduced pressure, and obtained 614.61g of eluate , and finally eluted with 120L of 95% ethanol aqueous solution, and the solvent was recovered under reduced pressure to obtain 69.47 g of the eluate; the activity test showed that the elution site with 50% ethanol was the active site. The extraction flow chart i...

Embodiment 2

[0026]A kind of hard ointment for relieving pain of osteoarthritis according to the embodiment of the present invention, the hard ointment for relieving pain of osteoarthritis described in this embodiment is made up of the following components by weight percentage: the composition for relieving pain of osteoarthritis 15% , 10% stearic acid, 55% methanol, 15% propylene glycol, 3% petrolatum, and the balance is deionized water.

[0027] The composition for alleviating the pain of osteoarthritis in the hard ointment for alleviating the pain of osteoarthritis is composed of the following components by weight: 60 parts of Panax notoginseng chrysanthemum extract, 25 parts of vinegar curcuma extract, fried Toosendem Sub-extract 15 parts.

[0028] The preparation method of the above-mentioned hard ointment for relieving osteoarthritis pain:

[0029] (1) mixing the composition for alleviating the pain of osteoarthritis, drying and pulverizing to obtain medicinal powder;

[0030] (2) ...

Embodiment 3

[0034] A kind of hard ointment for relieving pain of osteoarthritis according to the embodiment of the present invention, the hard ointment for relieving pain of osteoarthritis described in this embodiment is made up of the following components by weight percentage: the composition for relieving pain of osteoarthritis 20% , 25% stearic acid, 30% methanol, 30% propylene glycol, 5% petrolatum, and the balance is deionized water.

[0035] The composition for alleviating the pain of osteoarthritis in the hard ointment for alleviating the pain of osteoarthritis is composed of the following components by weight: 85 parts of Panax notoginseng Chrysanthemum extract, 35 parts of Vinegar Curcuma extract, fried Toosendem Sub-extract 25 parts.

[0036] The preparation method of the above-mentioned hard ointment for relieving osteoarthritis pain:

[0037] (1) mixing the composition for alleviating the pain of osteoarthritis, drying and pulverizing to obtain medicinal powder;

[0038] (2)...

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Abstract

The invention relates to a composition for relieving osteoarthritis pain and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition for relieving the osteoarthritis pain comprises the following components in parts by weight: 25-85 parts of a procumbent pseudo-ginseng and chrysanthemum extract, 10-35 parts of a vinegar-processed curcuma zedoary extract and 5-25 parts of a fried szechwan chinaberry fruit extract. The composition for relieving the osteoarthritis pain contains the procumbent pseudo-ginseng and chrysanthemum extract, and has various pharmacological effects of resisting inflammation, resisting infection and the like; the curcuma zedoary extract has the effects of promoting qi circulation, breaking blood, removing food retention and relieving pain; the szechwan chinaberry fruit has the effects of soothing liver and relieving heat, promoting qi circulation and relieving pain and killing insects; and a large number of studies find that the procumbent pseudo-ginseng and chrysanthemum extract, the curcuma zedoary extract and the szechwan chinaberry fruit extract in the composition have a synergistic effect, and the composition has the remarkable effects of promoting qi to activate blood and activating meridians to stop pain on relieving slight or moderate pain of osteoarthritis and pain such as traumatic injuries, sprains, muscular pain and fractures.

Description

technical field [0001] The invention relates to a composition for alleviating the pain of osteoarthritis and its application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Osteoarthritis (OA) is a chronic joint disease characterized by progressive destruction of articular cartilage and local involvement of various tissues. It is mostly manifested as joint pain, joint deformity and dysfunction, and mostly involves joints such as knees, hips, ankles, hands and spine. Chronic pain prevalent in OA patients is one of the main causes of decreased quality of life and even loss of mobility in people over 50 years old. Because the mechanism of OA chronic pain is still unclear, there is still no effective clinical treatment for OA pain control. Common western painkillers have many adverse reactions during treatment, such as constipation, nausea, fatigue, dizziness, drowsiness, vomiting, etc. Opioids also have respiratory depression a...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61K47/12A61K47/10A61K47/06A61P29/00A61P19/02A61P19/04A61P21/00A61P19/08
CPCA61K36/28A61K36/9066A61K36/58A61K9/06A61K9/0014A61K47/12A61K47/10A61K47/06A61P29/00A61P19/02A61P19/04A61P21/00A61P19/08A61K2300/00
Inventor 何蓉蓉梁磊贺晓静邹剑丁肇俊李怡芳余宗盛古润金
Owner 完美(广东)日用品有限公司
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