The invention relates to a high-precision punching device with a calibration function. The device includes a base, a support rod, an operation table, a punching mechanism, a calibration mechanism, anda clamping mechanism. According to the high-precision punching device with the calibration function, the calibration of a punching point and a drill can be achieved through the calibration mechanism,the clamping can be achieved through the clamping mechanism, and the punching can be achieved through the punching mechanism. Compared with an existing punching device, through coordination of the calibration mechanism and the clamping mechanism, the punching device make the punching point and the drill of a work piece keep alignment all the time, and the punching precision is improved. Comparedwith an existing calibration mechanism, the calibration mechanism adopts a purely mechanical mechanism to achieve determining and fixation of the punching point, a sensor is prevented from using, andthe service life is improved. Through linkage of determining assemblies and absorption assemblies, the fixation can be finished during determining, the better locating effect can be achieved, meanwhile through linkage of clamping assemblies and the absorption assemblies, a sucker absorbs the work piece well, and the absorption effect can be improved.