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41 results about "Fowl typhoid" patented technology
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The incidence of fowl typhoid is low in the USA, Canada, and some European countries but is much higher in other countries. Although S Gallinarum is egg-transmitted and produces lesions in chicks and poults similar to those produced by S Pullorum, there is a much greater tendency to spread among growing or mature flocks.
Novel bacteriophage and antibacterial composition comprising the same
Disclosed herein are is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Pullorum without affecting beneficial bacteria. Disclosed are also compositions, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum or Salmonella Pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the salmonella bacteria.
Owner:CJ CHEILJEDANG CORP
Novel bacteriophage and antibacterial composition comprising the same
ActiveUS20110052542A1Effective preventionEffective treatmentAntibacterial agentsBiocideBacteroidesFood poisoning
Disclosed herein is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Pullorum without affecting beneficial bacteria, in addition to showing excellent tolerance to acid, heat and desiccation. The novel bacteriophage can be widely used as an active ingredient for therapeutic agents, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum or Salmonella Pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the salmonella bacteria.
Owner:CJ CHEILJEDANG CORP
Novel Bacteriophage and Antibacterial Composition Comprising the Same
InactiveUS20100166709A1Good acidImprove the heating effectAntibacterial agentsBiocideFood poisoningBacteriophage
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Pullorum. Further, the present invention relates to a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella Enteritidis or Salmonella Typhimurium, Fowl Typhoid caused by Salmonella Gallinarum, and Pullorum disease caused by Salmonella Pullorum, comprising the bacteriophage as an active ingredient. Furthermore, the present invention relates to a feed additive, drinking water, a cleaner and a sanitizer, comprising the bacteriophage as an active ingredient.
Owner:CJ CHEILJEDANG CORP
Novel bacteriophage and antibacterial composition comprising same
InactiveCN102149816AImprove acid resistanceImprove heat resistanceAntibacterial agentsMammal material medical ingredientsDisinfectantFood poisoning
Owner:CJ CHEILJEDANG CORP
Novel bacteriophage and antibacterial composition comprising the same
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum and Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella enteritidis or Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient.
Owner:CJ CHEILJEDANG CORP
Salmonella broad-spectrum virulent bacteriophage as well as preparation method and application thereof
ActiveCN112662636AHigh potencyHas cracking abilityAntibacterial agentsDigestive systemSalmonella paratyphi ASerotype
The invention provides a salmonella broad-spectrum virulent bacteriophage. The preservation number of the bacteriophage is CCTCC NO: M 2020839. The invention also provides a preparation process and application of the salmonella broad-spectrum virulent bacteriophage, and the preparation process comprises fermentation and extraction; in the step of fermentation, a salmonella gallinarum attenuated vaccine strain is used as host bacteria for bacteriophage fermentation. The bacteriophage XPARCPS02 disclosed by the invention can be used for cracking salmonella of various serotypes and also has different degrees of cracking effects on drug-resistant bacteria; the salmonella typhimurium lysate lysate has a cracking capability on salmonella typhimurium, salmonella typhimurium drug-resistant bacteria, salmonella gallinarum, salmonella enteritidis, salmonella enteritidis drug-resistant bacteria, salmonella typhimurium, salmonella pullorum, salmonella paratyphi A, salmonella paratyphi B and salmonella dubicularis.
Owner:山东仙普爱瑞科技股份有限公司
Bacteriophage and antibacterial composition comprising the same
ActiveUS20140017205A1Good acidExcellent heat-resistanceBiocideViral/bacteriophage medical ingredientsInfectious DisorderFood poisoning
Disclosed herein is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum, and Salmonella pullorum without affecting beneficial bacteria, in addition to showing excellent tolerance to acid, heat and desiccation. The novel bacteriophage of the present invention can be widely used as an active ingredient for therapeutic agents, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum or Salmonella pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the Salmonella bacteria. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
Owner:CJ CHEILJEDANG CORP
Novel bacteriophage and antibacterial composition comprising the same
Disclosed herein are is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Pullorum without affecting beneficial bacteria. Disclosed are also compositions, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum or Salmonella Pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the salmonella bacteria.
Owner:CJ CHEILJEDANG CORP
Novel bacteriophage and antibacterial composition comprising the same
Disclosed herein are is a novel bacteriophage which has specific bactericidal activity against one or more Salmonella bacteria selected from the group consisting of Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum, and Salmonella Pullorum without affecting beneficial bacteria. Disclosed are also compositions, animal feeds or drinking water, cleaners and sanitizers for preventing and treating the infectious diseases caused by Salmonella Enteritidis, Salmonella Typhimurium, Salmonella Gallinarum or Salmonella Pullorum including salmonellosis, Salmonella food poisoning, Fowl Typhoid, and Pullorum disease or for controlling the salmonella bacteria.
Owner:CJ CHEILJEDANG CORP
Inert carrier indirect agglutination test detection system and application thereof
ActiveCN111537712ANo self-condensationSelf-condensation does not occurBiological material analysisDepsipeptidesSerum/Whole bloodAntigen
The invention discloses an inert carrier indirect agglutination test detection system and application thereof. The system comprises inert carrier bacteria S9 and a complex S9-P which is shown and expressed on the surface of the inert carrier bacteria S9 and carries a P-antibody factor. The system only carries the P-antibody factor, is single in component and specific in targeting, generates macroscopic positive particle agglutination reaction with whole blood or serum of chicken infected by pullorum disease and salmonella typhimurium under a certain concentration condition, and does not generate non-specific cross agglutination reaction with chicken-derived serum and whole blood of different backgrounds infected by non-pullorum disease and salmonella typhimurium. The S9-P is based on a glass plate agglutination reaction operation platform. The S9-P is simple and convenient to operate, sensitive and rapid in reaction, macroscopic in agglutination reaction particles and clear and easy inresult judgment, tests and result judgment are completed within two minutes, and the S9-P is suitable for targeted specific detection of pullorum disease and salmonella gallinarum infection in chicken flocks and has a good application prospect in on-site monitoring and diagnosis of the chicken flocks.
Owner:YANGZHOU UNIV
Bacteriophage and antibacterial composition comprising the same
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella typhimurium, Salmonella gallinarum, or Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
Owner:CJ CHEILJEDANG CORP
Primers, probes, a test kit and a test method for triple real-time fluorescence PCR detection of four bacteria
ActiveCN103060447AMicrobiological testing/measurementFluorescence/phosphorescenceSalmonella GallinarumFluorescence
The invention discloses primers, probes, a test kit and a test method for triple real-time fluorescence PCR detection of Salmonella choleraesuis, Salmonella paratyphi, Salmonella typhi, and Salmonella gallinarum. According to the present invention, a triple real-time PCR method is used, wherein a consensus sequence of Salmonella choleraesuis and Salmonella paratyphi is used for the detection of Salmonella choleraesuis and Salmonella paratyphi, a specific sequence of Salmonella typhi is used for the detection of Salmonella typhi, and a specific sequence of Salmonella gallinarum is used for the detection of Salmonella gallinarum. Whether a sample is contaminated by Salmonella choleraesuis, Salmonella paratyphi, Salmonella typhi, and Salmonella gallinarum is determined via a real-time fluorescence PCR amplification, and then Salmonella choleraesuis and Salmonella paratyphi are distinguished via a single fluorescent PCR amplification; the detection is rapid, the process of preparing sample and issuing test results can be finished in 31hours, the results are reliable, and sensitivity and specificity are high.
Owner:许龙岩 +5
PCR detection kit for rapidly identifying Salmonella Pullorum/Salmonella Gullinarum
ActiveCN108330176ARapid identificationGood repeatabilityMicrobiological testing/measurementAgainst vector-borne diseasesForward primerSerum ige
The invention belongs to the field of biotechnology detection, and particularly relates to a PCR detection kit for rapidly identifying Salmonella Pullorum / Salmonella Gullinarum, wherein the PCR detection kit comprises a SPUL_2693 gene detection primer pair, and the SPUL_2693 gene detection primer pair comprises a forward primer with a nucleotide sequence represented by SEQ ID NO.1 and a reverse primer with a nucleotide sequence represented by SEQ ID NO.2. According to the present invention, the kit can perform rapid and high-throughput identification on Salmonella Pullorum / Salmonella Gullinarum, can be used as the auxiliary method for the traditional serological typing of Salmonella, and provides the new simple, rapid and highly-sensitive method for the monitoring and laboratory diagnosisof Salmonella Pullorum / Salmonella Gullinarum.
Owner:YANGZHOU UNIV
Bacteriophage of the siphoviridae family and antibacterial compositions comprising the same
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella enteritidis, Salmonella typhimurium, Salmonella gallinarum and Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella enteritidis or Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient.
Owner:CJ CHEILJEDANG CORP
Traditional Chinese medicine composition for treating fowl typhoid and preparation method thereof
InactiveCN104644834AGood control effectAntibacterial effect is obviousAntibacterial agentsPowder deliverySide effectAdditive ingredient
The invention relates to a traditional Chinese medicine composition for treating fowl typhoid and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients, by weight, 20-40 parts of the root of Chinese pulsatilla, 10-20 parts of phellodendron, 10-20 parts of Scutellaria baicalensis, 10-20 parts of radix platycodi, 5-15 parts of honeysuckle flower, 10-20 parts of humifuse euphorbia herb and 10-20 parts of licorice. The traditional Chinese medicine composition has antimicrobial, anti-inflammation, heat-clearing and antidiarrheal effects, has little toxic and side effect, has no drug residue, is not easy to generate drug resistance, is convenient to use, is easy to absorb, has high bioavailability, meets requirements of safe veterinary drug and animal-derived food safety guarantee, and is an ideal traditional Chinese medicine composition for treating fowl typhoid.
Owner:TIANJIN REBATE SCI & TECH DEV
Veterinary compound gentamycin sulfate injection and preparation method thereof
InactiveCN101829129APromote absorptionProlong the action timeAntibacterial agentsOrganic active ingredientsDiseaseTrimethoprim
The invention relates to a veterinary compound gentamycin sulfate injection and a preparation method thereof. The injection consists of gentamicin sulphate, ofloxacin, analgin, trimethoprim, an organic solvent and injection water. The injection serving as a veterinary special compound preparation is mainly used for treating porcine epidemic diarrhea, transmissible gastrocnteritis, paratyphus vaccine for piglets, yellow and white scour for piglets, edema disease for piglets, and intestinal diseases, such as poultry colibacillosis, fowl typhoid, paratyphoid and the like. The injection has the advantages of convenient use, short period of treatment, low medicament resistance and the like.
Owner:陈建波
Pullorum disease salmonella spiC-rfc double-gene knockout attenuated strain and DIVA vaccine application thereof
The invention belongs to the field of fowl salmonellosis prevention and control and particularly relates to a pullorum disease salmonella spiC-rfc double-gene knockout attenuated strain and preparation and application thereof. The attenuated strain is pullorum disease salmonella in which a spiC gene or an rfc gene is not expressed. It is found through animal experiments that virulence of the mutant strain is remarkably reduced, and colonization time in a host body is shortened obviously. The attenuated strain is adopted for preparing pullorum disease salmonella live vaccine, after chickens are inoculated with the vaccine, no adverse reaction is generated, and strong virulence strain infection can be effectively eliminated. The host does not generate an anti-body aiming at O-antigen, by means of pullorum disease fowl typhoid multi-valence detection antigen, the attenuated stain can be effectively applied to glass plate agglutination experiments to distinguish immunized chickens and naturally infected chickens, and the characteristic of the DIVA vaccine is achieved.
Owner:YANGZHOU UNIV
Salmonella bacteriophage and antibacterial composition comprising the same
ActiveUS8288146B2Good acidImprove the heating effectAntibacterial agentsBiocideFood poisoningFowl typhoid
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella typhimurium, Salmonella gallinarum, or Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient.
Owner:CJ CHEILJEDANG CORP
Pullorum disease salmonella spiC-rfaH double-gene knockout attenuated strain and DIVA vaccine application thereof
InactiveCN105483049AImproving immunogenicitySolid immune protectionAntibacterial agentsBacteriaAntigenVirulent characteristics
The invention belongs to the field of fowl salmonellosis prevention and control and particularly relates to a pullorum disease salmonella spiC-rfaH double-gene knockout attenuated strain and preparation and application thereof. The attenuated strain is pullorum disease salmonella in which a spiC gene or an rfaH gene is not expressed. It is found through animal experiments that virulence of the mutant strain is remarkably reduced, and colonization time in a host body is shortened obviously. The attenuated strain is adopted for preparing a pullorum disease salmonella live vaccine, after chickens are inoculated with the vaccine, no adverse reaction is generated, and strong virulence strain infection can be effectively eliminated. The host does not generate an anti-body aiming at O-antigen, by means of the pullorum disease fowl typhoid multi-valence detection antigen, the attenuated stain can be effectively applied to glass plate agglutination experiments to distinguish immunized chickens from naturally infected chickens, and the characteristic of the DIVA vaccine is achieved.
Owner:YANGZHOU UNIV
Pullorum disease salmonella spiC-rfaI double-gene knockout attenuated strain and DIVA vaccine application thereof
InactiveCN105483048ALow toxicityImprove protectionAntibacterial agentsBacteriaAntigenVirulent characteristics
The invention belongs to the field of fowl salmonellosis prevention and control and particularly relates to a pullorum disease salmonella spiC-rfaI double-gene knockout attenuated strain and preparation and application thereof. The attenuated strain is pullorum disease salmonella in which a spiC gene or an rfaI gene is not expressed. It is found through animal experiments that virulence of the mutant strain is remarkably reduced, and colonization time in a host body is shortened obviously. The attenuated strain is adopted for preparing pullorum disease salmonella live vaccine, after chickens are inoculated with the vaccine, no adverse reaction is generated, and strong virulence strain infection can be effectively eliminated. The host does not generate an anti-body aiming at O-antigen, by means of the pullorum disease fowl typhoid multi-valence detection antigen, the attenuated stain can be effectively applied to glass plate agglutination experiments to distinguish immunized chickens and naturally infected chickens, and the characteristic of the DIVA vaccine is achieved.
Owner:YANGZHOU UNIV
Bacteriophage and antibacterial composition comprising the same
ActiveUS20130022579A1Specific bactericidal activityAntibacterial agentsBiocideAnaplasma phagocytophilumFood poisoning
The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Salmonella typhimurium, Salmonella gallinarum, or Salmonella pullorum, a composition for the prevention or treatment of infectious diseases including salmonellosis and Salmonella food poisoning caused by Salmonella typhimurium, Fowl typhoid caused by Salmonella gallinarum, and Pullorum disease caused by Salmonella pullorum, which comprises the bacteriophage as an active ingredient, and an animal feed, drinking water, cleaner, and sanitizer which comprise the bacteriophage as an active ingredient. The present invention also provides important insights into prevention and control strategies against Salmonella infection and suggests that the use of bacteriophage can be a novel, safe, and effectively plausible alternative to antibiotics for the prevention of Salmonella infection in poultry.
Owner:CJ CHEILJEDANG CORP
Water-soluble trimethoprim composition and compounded composition thereof
InactiveCN106265527ASolve the problem of insoluble in waterSolve the problem of mixing evenly and affecting the treatment effectAntibacterial agentsPowder deliveryCoccidiosisTreatment effect
The invention provides a water-soluble trimethoprim composition and a compounded composition thereof. After being treated through a special process, trimethoprim can be uniformly dispersed in water together with sulfanilamide salt, and can be used for effectively solving the problems that a premixing agent is unevenly mixed in the feed and influences the treatment effect. The water-soluble trimethoprim composition is applied through hydroposia, has obvious treatment effects on blood poisoning, white diarrhea, fowl typhoid, cholera, unknown high heat, respiratory system secondary bacterial infection and the like caused by poultry colibacillus, and can be used for preventing and treating coccidiosis. The preparation method is simple in operation, free from pollution and suitable for industrial production.
Owner:江西派尼生物药业有限公司
Quintuple PCR detection method and detection kit for avian escherichia coli, chicken typhoid salmonella, salmonella pullorum and the like
ActiveCN107201400AStrong specificityIncreased sensitivityMicrobiological testing/measurementMicroorganism based processesEscherichia coliSalmonella enteritidis
The invention provides a multiple PCR primer group for avian escherichia coli, chicken typhoid salmonella, salmonella pullorum, salmonella enteritidis and bacillus breslaviensis, a quintuple PCR detection kit comprising the primer group and a quintuple PCR detection method. The primer group comprises primer pairs ECphoA-F and ECphoA-R for specific amplification of avian escherichia coli phoA genes, primer pairs SGg1gC-F and SGg1gC-R for specific amplification of chicken typhoid salmonella glgC genes, primer pairs SGPspeC-F and SGPspeC-R for specific amplification of chicken typhoid salmonella and salmonella pullorum genes, primer pairs SEsdf I-F and SEsdf I-R for specific amplification of salmonella enteritidis sdf-1 genes and primer pairs STstm4495-F and STstm4495-R for specific amplification of bacillus breslaviensis stm4495 genes.
Owner:SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
Pullorum disease salmonella spiC-rfaL double-gene knockout attenuated strain and DIVA vaccine application thereof
InactiveCN105483051ALow toxicityImproving immunogenicityAntibacterial agentsBacteriaAntigenVirulent characteristics
The invention belongs to the field of fowl salmonellosis prevention and control and particularly relates to a pullorum disease salmonella spiC-rfaL double-gene knockout attenuated strain and preparation and application thereof. The attenuated strain is pullorum disease salmonella in which a spiC gene or an rfaL gene is not expressed. It is found through animal experiments that virulence of the mutant strain is remarkably reduced, and colonization time in a host body is shortened obviously. The attenuated strain is adopted for preparing pullorum disease salmonella live vaccine, after chickens are inoculated with the vaccine, no adverse reaction is generated, and strong virulence strain infection can be effectively eliminated. The host does not generate an anti-body aiming at O-antigen, by means of pullorum disease fowl typhoid multi-valence detection antigen, the attenuated stain can be effectively applied to glass plate agglutination experiments to distinguish immunized chickens and naturally infected chickens, and the characteristic of the DIVA vaccine is achieved.
Owner:YANGZHOU UNIV
Bacteriophage and antibacterial composition comprising the same
ActiveUS8846368B2Improve tolerancePrevention and treatment of infectious diseasesBiocideViral/bacteriophage medical ingredientsBacteroidesFood poisoning
Owner:CJ CHEILJEDANG CORP
Salmonella bacteriophage and antibacterial composition comprising the same
ActiveUS8293515B2Effective preventionEffective treatmentAntibacterial agentsBiocideFood poisoningFowl typhoid
Owner:CJ CHEILJEDANG CORP
Bacteriophage and antibacterial composition comprising the same
ActiveUS8148131B2Improve the heating effectSpecific bactericidal activityAntibacterial agentsBiocideAnaplasma phagocytophilumBULK ACTIVE INGREDIENT
Owner:CJ CHEILJEDANG CORP
Salmonella bacteriophage CKT1 without transduction of drug-resistant gene and application of salmonella bacteriophage CKT1
The invention discloses a salmonella bacteriophage CKT1 without transduction of drug-resistant gene and application of the salmonella bacteriophage CKT1, the virulent bacteriophage CKT1 is preserved in China Center for Type Culture Collection on January 21, 2022, and the preservation number of the virulent bacteriophage CKT1 is CCTCC (China Center for Type Culture Collection) 2022110. The separated salmonella bacteriophage CKT1 has splitting activity on D-group salmonella such as salmonella pullorum, salmonella gallinarum and salmonella enteritidis from different sources, is short in incubation period, high in progeny bacteriophage outbreak amount and low in bacteriophage mutation resistance rate, does not carry virulence genes and drug-resistant genes on a genome, does not have transduction capability, and can be used for preparing the salmonella bacteriophage CKT1. The bacteriophage does not cause transmission of drug-resistant genes, is a safe, efficient and high-specificity virulent bacteriophage, and does not destroy intestinal flora of chicks. The bacteriophage preparation can become a novel environment-friendly auxiliary means for purifying salmonella pullorum in a breeding chicken farm, and is also an alternative strategy for preventing and treating salmonella pullorum or salmonella gallinarum infection of chicken flocks.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Live salmonella vaccine and methods to prevent fowl typhoid
InactiveUS20170049872A1PeptidesAntibody medical ingredientsVirulent characteristicsRecombinant vaccines
We constructed S. Gallinarum strains deleted for the global regulatory gene fur (FIG. 1) and evaluated their virulence and protective efficacy in Rhode Island Red chicks and Brown Leghorn layers. The fur deletion mutant was a virulent and, when delivered orally to chicks, elicited excellent protection against lethal S. Gallinarum challenge. We also examined the effect of a pmi mutant and a combination of fur deletions with mutations in the pmi and rfaH genes, which affect O-antigen synthesis, and ansB, whose product inhibits host T cell responses. The ΔAfur Δpmi and Δfur ΔansB double mutants were attenuated, but not protective when delivered orally to chicks. However, a Δpmi Δfur strain was substantially immunogenic when administrated intramuscularly. Altogether our results show that the fur gene is essential for virulence of S. Gallinarum and the fur mutant is effective as a live recombinant vaccine against fowl typhoid.
Owner:ARIZONA STATE UNIVERSITY
PCR detection kit for rapidly detecting salmonellae and identifying salmonella pullorum/salmonella gallinarum and application thereof
PendingCN111733266AHigh sensitivityStrong specificityMicrobiological testing/measurementMicroorganism based processesForward primerNucleotide
The invention provides a PCR detection kit for rapidly detecting salmonella and identifying salmonella pullorum / salmonella gallinarum and an application thereof. According to the applicant, a primer is designed for a cigR gene, a PCR detection technology is adopted for detecting the cigR gene, and whether a detected object belongs to salmonellae or not or whether the detected object is the salmonella pullorum / salmonella gallinarum or not can be analyzed and judged according to amplification and detection conditions. In a specific scheme, the detection kit at least comprises a forward primer asshown in SEQ ID NO.1 and a reverse primer with a nucleotide sequence as shown in SEQ ID NO.2. The kit is simple, rapid, good in specificity, high in sensitivity and good in repeatability.
Owner:YANGZHOU UNIV
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