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Water-soluble trimethoprim composition and compounded composition thereof

A compound composition, trimethoprim technology, applied in the directions of drug combination, pharmaceutical formulation, organic active ingredients, etc., can solve the problem that trimethoprim is insoluble in water, the premix is ​​difficult to mix evenly, and the treatment effect is affected, etc. problems, to achieve the effects of fast drug absorption, convenient administration, and simple production process

Inactive Publication Date: 2017-01-04
江西派尼生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a water-soluble trimethoprim composition, which solves the problem that trimethoprim is difficult to dissolve in water. The present invention further provides a compound combination of a composition containing water-soluble trimethoprim Drugs are administered through drinking water, which effectively solves the problem that the premix is ​​difficult to mix evenly in the feed and affects the therapeutic effect.

Method used

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  • Water-soluble trimethoprim composition and compounded composition thereof
  • Water-soluble trimethoprim composition and compounded composition thereof
  • Water-soluble trimethoprim composition and compounded composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Trimethoprim (Shouguang Fukang Pharmaceutical Co., Ltd.)

Embodiment 2

[0030] Preparation of compound composition containing trimethoprim:

[0031] Trimethoprim 2.0g

[0032] Sulfachlordazine Sodium 10.0g

[0033] Preparation method: Weigh 2.0 g of trimethoprim (Shouguang Fukang Pharmaceutical Co., Ltd.) and 10.0 g of sulfachlordazine sodium, and mix them uniformly to obtain a powder compound composition.

Embodiment 3

[0035] Preparation of compound composition containing trimethoprim:

[0036] Trimethoprim 2.0g

[0037] Sulfachlordazine Sodium 10.0g

[0038] Sucrose 88.0g

[0039] Preparation method: Weigh 2.0 g of trimethoprim (Shouguang Fukang Pharmaceutical Co., Ltd.) and 10.0 g of sulfachlordazine sodium, mix uniformly, add 88.0 g of sucrose, and mix uniformly to obtain a powder compound composition.

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Abstract

The invention provides a water-soluble trimethoprim composition and a compounded composition thereof. After being treated through a special process, trimethoprim can be uniformly dispersed in water together with sulfanilamide salt, and can be used for effectively solving the problems that a premixing agent is unevenly mixed in the feed and influences the treatment effect. The water-soluble trimethoprim composition is applied through hydroposia, has obvious treatment effects on blood poisoning, white diarrhea, fowl typhoid, cholera, unknown high heat, respiratory system secondary bacterial infection and the like caused by poultry colibacillus, and can be used for preventing and treating coccidiosis. The preparation method is simple in operation, free from pollution and suitable for industrial production.

Description

technical field [0001] The invention relates to a water-soluble trimethoprim composition and its compound composition, belonging to the field of veterinary medicine. Background technique [0002] As a class of chemotherapeutic drugs, sulfa drugs have played a very good role in the control of bacterial diseases and coccidiosis. At present, there are more than 10 kinds of sulfonamide drugs used in the field of veterinary medicine. These drugs have the advantages of broad antibacterial spectrum, oral administration, rapid absorption, and stable properties; but they also have many adverse reactions, and bacteria are prone to drug resistance. Large and long courses of treatment and other defects. After the discovery of trimethoprim and other antibacterial synergists, the combination of sulfonamides and synergists greatly enhanced the antibacterial activity. Therefore, sulfonamides are still important drugs in the treatment of livestock and poultry anti-infection and coccidiosis....

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/505A61K31/635A61K47/34A61K47/32A61P31/04A61P33/02
CPCA61K9/0095A61K9/146A61K31/505A61K31/635A61K2300/00
Inventor 谢艳霞易全茂曾繁山
Owner 江西派尼生物药业有限公司
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