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Veterinary compound gentamycin sulfate injection and preparation method thereof

A technology of gentamicin sulfate and injection, which is applied in the direction of medical preparations containing active ingredients, blood diseases, pharmaceutical formulas, etc., can solve the problems of incomplete curative effect, achieve broad antibacterial spectrum, low drug resistance, The effect of high bioavailability

Inactive Publication Date: 2010-09-15
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dose of the injection is accurate and the effect is reliable, unlike the internal medicine that may be affected by digestive juices, food, etc., and the dose used cannot fully produce the curative effect

Method used

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  • Veterinary compound gentamycin sulfate injection and preparation method thereof
  • Veterinary compound gentamycin sulfate injection and preparation method thereof
  • Veterinary compound gentamycin sulfate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound gentamycin sulfate injection for veterinary use contains the following components, all in parts by weight:

[0032] 4 parts of gentamicin sulfate, 2 parts of ofloxacin, 1.5 parts of trimethoprim, 30 parts of analgin, 0.15 parts of sodium bisulfite, 0.04 parts of disodium edetate, N, N-di 20 parts of methyl formamide, 15 parts of propylene glycol, 3.5 parts of glacial acetic acid; 40 parts of water for injection.

[0033] The preparation method of aforementioned veterinary compound gentamicin sulfate injection, the steps are as follows:

[0034] 1) After dissolving 1.5 parts of trimethoprim with 20 parts of N,N-dimethylformamide, a trimethoprim solution was obtained;

[0035] 2) After dissolving 2 parts of ofloxacin with 2 parts of glacial acetic acid and 5 parts of water for injection, a solution of ofloxacin is obtained;

[0036] 3) Dissolve 30 parts of Sulpyrine in 25 parts of water for injection to obtain a Sulpyrine solution; dissolve 4 parts of gentami...

Embodiment 2

[0054] A compound gentamycin sulfate injection for veterinary use contains the following components, all in parts by weight:

[0055] 2 parts of gentamicin sulfate, 4 parts of ofloxacin, 2 parts of trimethoprim, 10 parts of analgin, 0.1 part of sodium bisulfite, 0.02 part of disodium edetate, N, N-di 35 parts of methyl formamide, 15 parts of propylene glycol, 6 parts of glacial acetic acid; 30 parts of water for injection.

[0056] The preparation steps were the same as in Example 1 to obtain compound gentamycin sulfate injection for veterinary use, with a pH of 3.7.

[0057] Table 3 The present invention (experimental example 2) clinical treatment effect

[0058]

[0059] Table 4 The present invention and Gentamicin Sulfate Injection clinical treatment comparative test result

[0060]

Embodiment 3

[0062] A compound gentamycin sulfate injection for veterinary use contains the following components, all in parts by weight:

[0063] 5 parts of gentamicin sulfate, 5 parts of ofloxacin, 2.5 parts of trimethoprim, 30 parts of analgin, 0.2 parts of sodium bisulfite, 0.04 parts of disodium edetate, N, N-di 25 parts of methyl formamide, 10 parts of propylene glycol, 7.5 parts of glacial acetic acid; 25 parts of water for injection.

[0064] The preparation steps were the same as in Example 1 to obtain compound gentamycin sulfate injection for veterinary use, with a pH of 3.9.

[0065] Table 5 The present invention (experimental example 3) clinical treatment effect

[0066]

[0067] Table 6 The present invention and Gentamicin Sulfate Injection clinical treatment comparative test result

[0068]

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PUM

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Abstract

The invention relates to a veterinary compound gentamycin sulfate injection and a preparation method thereof. The injection consists of gentamicin sulphate, ofloxacin, analgin, trimethoprim, an organic solvent and injection water. The injection serving as a veterinary special compound preparation is mainly used for treating porcine epidemic diarrhea, transmissible gastrocnteritis, paratyphus vaccine for piglets, yellow and white scour for piglets, edema disease for piglets, and intestinal diseases, such as poultry colibacillosis, fowl typhoid, paratyphoid and the like. The injection has the advantages of convenient use, short period of treatment, low medicament resistance and the like.

Description

(1) Technical field [0001] The invention relates to a veterinary compound gentamycin sulfate injection and a preparation method thereof, belonging to the technical field of veterinary drug injections. (2) Background technology [0002] Gentamycin Sulfate (Gentamycin Sulfate) is an aminoglycoside drug with a broad antibacterial spectrum and moderate antibacterial activity. It is effective against Pseudomonas aeruginosa, E. , Shigella, Brucella, etc. have strong effects, especially against Pseudomonas aeruginosa. [0003] Ofloxacin has broad-spectrum antibacterial activity against most Gram-negative and positive bacteria, some anaerobic bacteria and mycoplasma, and has good antibacterial activity against gentamicin-resistant Pseudomonas aeruginosa. Strong, high bioavailability, for intestinal infection, respiratory infection, urinary tract infection, skin and soft tissue infection caused by sensitive bacteria; for mixed infection of mycoplasma and bacteria. [0004] Analgin ...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K31/5383A61K31/505A61K31/4152A61K9/08A61P31/04A61P1/12A61P1/00A61P7/10A61P29/00
Inventor 陈建波陈抗
Owner 陈建波
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