119 results about "Epigenetics" patented technology

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell.

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell.

The present invention concerns the chemically modified genomic sequences of genes associated with angiogenesis, oligonucleotides and / or PNA oligomers directed against the sequence for the detection of the cytosine methylation state of genes associated with angiogenesis as well as a method for determining genetic and / or epigenetic parameters of genes associated with angiogenesis.

A system and method for determining the functional impact of somatic mutations and genomic aberrations on downstream cellular processes by integrating multi-omics measurements in cancer samples with community-curated biological pathways are disclosed. The method comprises the steps of extracting biological pathway information from well-curated biological pathway sources, using the pathway information to generate an upstream regulatory parent sub-network tree for each gene of interest, integrating measurement-based omic data for both cancer and normal samples to determine a nonlinear function for each gene expression level based on the gene's epigenetic information and regulatory network status, using the nonlinear function to predict gene expression levels and compare activation and consistency scores with inputted patient- specific gene expression data, and using the patient-specific gene expression predictions to identify significant deviations and inconsistencies in gene expressionlevels from expected levels in individual patient samples to identify potential biomarkers in providing predictive information in relation to cancer and cancer treatment.

The invention discloses a global optimization, searching and machine learning method based on a Lamarck's principle of inheritance of acquired characters. The global optimization, searching and machine learning method comprises the steps of: step 1, constructing an objective function f(x) according to a problem object; step 2, encoding the problem object into a chromosome of a genetic algorithm, automatically calculating or inputting operation parameters, and performing initialization; step 3, performing iterative optimization on a current (kth generation) population Gk={Pk<1>, Pk<2>,..., Pk<S>} by adopting a Lamarck's ''operator of inheritance of acquired characters'' and a ''use and disuse operator'' according to evaluation of the objective function f(x); step 4, and outputting an optimal solution set of the problem object. The global optimization, searching and machine learning method integrates the ''inheritance of acquired characters'' and ''use and disuse'' natural laws of Lamarck's evolution theory with the modern ''epigenetics'' and the ''survival of the fittest'' natural law of Darwin's evolution theory, simplifies the structure of the genetic algorithm, overcomes the multiple technical defects of the existing algorithm, and improves the efficiency, global optimality and sustainability of late evolution of the algorithm, so that more global optimization, searching and machine learning problems can be better solved.

Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squamous cell carcinoma, as are methods of treating a subject having such a cancer.

The present invention relates to a 5-formylcytosine specific chemical labeling method and related applications in aspects such as sequencing, detection, imaging, and diagnosis. In the method, a condensation reaction occurs between an active methylene group in an active methylene compound containing a side-chain reactive group and an aldehyde group in 5-formylcytosine or a 1-substituted derivative of 5-formylcytosine, and at the same time an intramolecular reaction occurs between the side-chain reactive group of the active methylene compound and a 4-amino group of cytosine to implement ring closing. By means of the 5-formylcytosine specific chemical labeling method and related compounds of the present invention, detection of the content of 5-formylcytosine in nucleic acid molecules, and specific concentration of 5-formylcytosine-containing nucleic acid samples, and analysis of sequence distribution information of 5-formylcytosine and / or single-base resolution sequence information in nucleic acid molecules and the like may be implemented. The present invention provides various effective research methods in the research fields of epigenetics and nucleic acid biochemistry.

The present invention relates to a method to reprogramming pluripotent stem cells (PSCs) by epigenetic conditioning and metabolic reprogramming into p PSCs with highly controllable biological functions, the cells obtained by said method as well as methods of using said cells.

The invention discloses a tumor resource tissue library and a method for establishing the same. The tumor resource tissue library comprises a tumor resource warehouse, tumor tissue samples and a tumordatabase. With the tumor resource tissue library, a problem of collecting fresh tumor tissues difficultly in the prior art is solved; the case resources are protected and utilized fully and reasonably; proper tumor samples are provided for the researchers; the research cycle is reduced, and the related researches on the lymphoma and other tumors are promoted. Therefore, research materials are provided for research workers in the fields of genetics, epigenetics, cell and molecular biology, genomics and proteomics and the like; and the bases are provided for tumor mutagenesis screening, geneticcounseling of high-risk populations, epidemiological characteristics of malignant tumors and tumor classification, early diagnosis, prognosis assessment and individualized treatment.

The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein Z1, Z2, X, R1 to R8 and Y are defined as described in the specification, or a pharmaceutically acceptable form or prodrug thereof, that are inhibitors of methyl transferases such as protein lysine methyltransferases and more particularly SMYD3. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders / conditions / diseases involving, relating to or associated with enzymes having methyl transferase activities / functions and / or via unspecified / multi-targeted mechanisms.

Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squamous cell carcinoma, as are methods of treating a subject having such a cancer.