34 results about "Danazol" patented technology

The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The method comprises administering an effective amount of a danazol compound to the animal accounting for the body fat content of the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal.

Pharmaceutical preparations for topical or local administration of drugs directly to the skin for treatment of disorders of the subcutaneous fatty tissue, in particular in cases of cellulite, are disclosed herein. In a preferred embodiment, the drug is danazol or gastrinone. In another embodiment, the drug is danazol in combination with an aromatase inhibitor or an estrogen compound. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion, ointment, gel or emulsion, solution or foam.

The invention provides a preparation method of danazol. According to the preparation method of the danazol, androstenedione is used as an initial raw material, through 2-position secondary hydroxymethylation reaction, 17-position carbonyl ethinylation reaction and oximation reaction, the danazol can be prepared, and the 2-position secondary hydroxymethylation reaction and the 17-position carbonylethinylation reaction are completed in one step. The preparation method of the danazol has the advantages of being safe, short in reaction step, high in yield, efficient in reaction and the like, andin the reaction, no flammable and combustible acetylene gas with huge potential safety hazards is used, so that preparation in which potassiumacetylide is replaced by ethynylmagnesium bromide is safer. Meanwhile, the reaction which needs to be completed in four steps before is completed in one step, the reaction is more efficient, meanwhile, operation is simple, and reaction time is short.

This invention involves one kind of medicinal purposes protein textile fiber which is used for preventing and curing hyperplasia of mammary glands, and the process and application. The compound according to textile fiber gross is as follows: percentage A is protein, percentage B is high polymer, percentage C is medicine, percentage D is medicine that passes the skin absorption promoter, and the percentage is: 1<=A<=80,1<=B<=80,0<C <=20,0<D<=10. Among them, the high polymer is a kind of or a combination of polyvinyl alcohol, polyacrylonitrile, cellulose, polyvinyl acetate; the medicine can be one or a combination of xifen, isoflavone, bromocriptine and danazol; the medicine skin penetration enhancer can also be one or a combination of nitrogen alkone, oleic acid, N- methyl - 2- pyrrolidone, trimethylene glycol, or borneol.

The invention discloses a method to make medicine using Chitin-fiber used for prevent hyperplasia of mammary glands and the application. It contains Chitin, medicine and medicine adsorbing accelerant. The medicine includes one or more from Tamoxifen, isoflavone, bromocriptine and Danazol. The medicine adsorbing accelerant is one or the compound from azone, oleic acid, N-methyl-2- pyrrolidone, propylene glycol, and borneol. The Chitin contains weight proportion of A, medicine contains weight proportion of B and medicine adsorbing accelerant contains weight proportion of C, and 60<A<=99, 0<B<=30, 0<C<=10. The invention also discloses the manufacturing method for the fiber and the method to make bra from the fiber.

A preparation method of ultra-fine danazol powder belongs to the method of drug micronization. The method is that danazol solution and desolvation are first put into a supergravity rotating bed through a solution entrance 4 and a desolvation entrance 5 respectively at the same time, and the recrystallized danazol paste by the desolvation flows out from a discharge hole 1; the danazol paste is collected, filtered and dried to obtain the ultra-fine danazol powder. The method can obtain the ultra-fine danazol powder of controlled average grain size, controlled shape and narrow grain size distribution.

The present invention discloses the application of wasp's nest in preparing medicine for treating endometriosis. Animal test proves the obvious endometriosis treating effect of wasp's nest, and what is more important is that wasp's nest possesses inapproachable safety compared with danazol. With high treating effect and basically no adverse effect, wasp's nest possesses excellent application foreground in treating endometriosis.

The invention discloses a testosterone detection reagent based on a microparticle chemiluminescence immunoassay technology; the testosterone detection reagent comprises the following components: 0.002%-0.01% of paramagnetic microspheres, 0.4 mug / ml-1 mug / ml of acridinium ester labeled testosterone antibodies, a composite testosterone release agent, a luminescence liquid A, a luminescence liquid B, 0ng / dl-1500ng / dl of a testosterone calibrator and a cleaning fluid with a certain concentration; and the testosterone release agent is a mixture of dihydrotestosterone, danazol and heparin sodium. The testosterone detection reagent has the advantages of simple operation, high sensitivity, fast detection efficiency, low cost, easy automation and the like, and by combination of the selected composite release agent and different binding globulin, combined-state testosterone in serum can be fully released, so that the content detection of total testosterone is more accurate.

The invention discloses a preparation method of danazol and its intermediate, which uses androstenedione as a starting material, undergoes etherification of 3-position enol, 17-position carbonyl acetylation, 3-position hydrolysis, 2-position Secondary hydroxylation and oximation to obtain danazol. The etherification of the 3-position enol is firstly reacted with androstenedione and triethyl orthoformate in the presence of absolute ethanol and p-toluenesulfonic acid at a temperature of 30-50°C for 4-10 hours; Add triethylamine at a temperature of 10°C to continue the reaction for 0.2~1h; the ethynylation of the 17-position carbonyl is to first react potassium hydroxide powder in an acetylene stream at a temperature of 5~10°C for 1~2h; and then react with the 3-position The enol etherification product is reacted in the acetylene gas stream at a temperature of 15-30° C. for 2-4 hours in the presence of tetrahydrofuran and a catalyst. The reaction conditions of the 3-position enol etherification reaction in the present invention are mild, and the yield is high, while the 17-position carbonyl ethynylation reaction has a high yield and a short time.

The present invention discloses the application of puerasin in preparing medicine for treating endometriosis. Animal test proves the obvious endometriosis treating effect of puerasin, and what is more important is that puerasin possesses inapproachable safety compared with danazol. With high treating effect and basically no adverse effect, puerasin possesses excellent application foreground in treating endometriosis.

The invention relates to a medicinal polyacrylonitrile fiber for preventing hyperplasia of mammary glands, its manufacturing method and application. A medicinal polyacrylonitrile fiber for preventing hyperplasia of mammary glands, wherein the proportion of polyacrylonitrile to A in the total weight of the fiber is 60<A≤99, the proportion of medicine to B in the total weight of the fiber is 0<B≤30, and the medicine is transdermal The C portion of the absorption promoter accounting for the total weight of the fiber is 0<C≤10, and the drug is one of tamoxifen, isoflavones, bromocriptine and danazol or a combination of more than one; The drug transdermal absorption accelerator is one of azone, oleic acid, N-methyl-2-pyrrolidone, propylene glycol, borneol or a combination of more than one. The invention has a simple manufacturing process and is easy to realize; the source of raw materials is abundant and the cost is low; the bra made of medicinal polyacrylonitrile fiber cloth prevents hyperplasia of mammary glands, which is convenient in medication, has little side effects, and does not affect the external beauty of patients, which is very suitable for modern women Human needs for healing and pursuing beauty.