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Use of kakonein in preparing medicine for treating endometriosis

A technology of endometrium and puerarin, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of high price, liver function damage, easy recurrence, etc.

Inactive Publication Date: 2010-10-27
俞超芹 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the decrease in the level of this diol, the patient has a change similar to that of menopause, which brings more obvious side effects
At the same time, these drugs are expensive, and long-term use can cause liver damage, and they are prone to relapse after drug withdrawal. These shortcomings limit the application of these drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Water solvent:

[0017] Take 1000ml of pyrogen-free deionized pure distilled water to dissolve 30000mg of puerarin, mix evenly, sterilize and make 30mg / ml water solvent, bottle it to make the finished product.

Embodiment 2

[0019] 1 Material:

[0020] 1.1 Experimental animals:

[0021] 90 healthy, sexually mature and unmated female SD rats, aged 70d-80d, each rat weighing 160-180g. The rats were provided by the Animal Center of Fudan University School of Medicine, and were kept in the animal room of the Animal Experiment Center of this hospital with 12 hours of light and 12 hours of darkness.

[0022] 1.2 Main equipment:

[0023] Forma725 -80°C low-temperature refrigerator (USA), BCD-248 ordinary refrigerator (Qingdao Haier Group), Olympus PM-10AD microscope (Japan OLYMPUS company), high-speed low-temperature centrifuge (Germany Hereaus company), Access automatic particle chemistry Luminescence analyzer (Beckman Coulter, USA), Array 360 specific protein analyzer (Beckman Coulter, USA), homogenizer, wet box, incubator, wax dipping box, embedding box, slicer , oven, etc.

[0024] 1.3 Main reagents:

[0025] Cytochrome aromatase P450 monoclonal antibody (purchased from Beijing Zhongshan Bioengi...

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PUM

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Abstract

The present invention discloses the application of puerasin in preparing medicine for treating endometriosis. Animal test proves the obvious endometriosis treating effect of puerasin, and what is more important is that puerasin possesses inapproachable safety compared with danazol. With high treating effect and basically no adverse effect, puerasin possesses excellent application foreground in treating endometriosis.

Description

technical field [0001] The present invention relates to a new application of puerarin, especially the application in preparing medicine for treating endometriosis. Background technique [0002] Puerarin is a flavonoid glycoside extracted from the root of the leguminous plant Pueraria lobata (pueraria lobata). In China, Fang Qicheng and others successfully extracted puerarin in 1974, and in 1993, puerarin was approved by the Ministry of Health for clinical use. As a new drug for improving cardiovascular and cerebrovascular circulation, it has become a drug widely used clinically because of its low toxicity, wide safety range and good curative effect. [0003] Endometriosis is the appearance of functional endometrium outside the inner wall of the uterine cavity. It causes secondary dysmenorrhea, infertility, chronic pelvic pain and other symptoms that seriously affect the quality of life of patients. Although endometriosis is a benign gynecological disease, it is aggressive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P15/00
Inventor 俞超芹石书芳
Owner 俞超芹
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