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Medicine for treating endometriosis and preparation method thereof

A technology for endometriosis and endometrium, which is applied in the field of medicine for treating endometriosis and its preparation, can solve rare problems, and achieve the effect of gentle medicine, obvious formula characteristics, and remarkable clinical curative effect

Inactive Publication Date: 2008-06-04
北京羚锐伟业科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] To sum up, the traditional Chinese medicine used in the market to treat endometriosis is still rare.

Method used

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  • Medicine for treating endometriosis and preparation method thereof
  • Medicine for treating endometriosis and preparation method thereof
  • Medicine for treating endometriosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of the present invention's medicine for treating endometriosis

[0027] The medicine for treating endometriosis, the prescription of which is as follows: rhubarb 300g, turtle shell 300g, amber 150g.

[0028] The method for preparing the medicine for treating endometriosis comprises the following specific steps:

[0029] 1) Weigh the medicinal materials according to the components and their weights in the above-mentioned traditional Chinese medicine prescription, and perform routine pretreatment;

[0030] 2) Soak rhubarb plus 85% ethanol in 8 times amount for 1 hour, reflux extraction three times, each time for 1 hour, filter, combine the filtrate for 3 times, recover ethanol and concentrate under reduced pressure to a relative density of 1.08-1.10 (25°C) ;

[0031] 3) Turtle shells were extracted four times with 10 times the amount of water, each time for 8 hours, filtered, combined filtrates, and concentrated under reduced pressure to a ...

Embodiment 2

[0039] Embodiment 2, the experiment of the influence of the medicine of the present invention for treating endometriosis on rat endometriosis model

[0040] Adopt the medicine for the treatment of endometriosis prepared by embodiment 1 (clinical experiment is named as endometriosis sheet), carry out animal experiment to rat endometriosis, by contrast experiment, investigate medicine of the present invention to endometrium Therapeutic effects in atopic rats. The specific experimental process is as follows:

[0041] (1) Methods: Wistar rats were used to establish endometriosis animal models by autologous endometrial pelvic transplantation. 0.1ml / kg of estradiol benzoate was intramuscularly injected 2 days before modeling, and intraperitoneally injected with pentobarbital sodium 30mg / kg for 2 days. From the right side of the uterus to 2cm away from the ovary, a section of uterus about 2cm in the middle was taken after ligation, the endometrium was stripped from the muscle layer...

Embodiment 3

[0062] Embodiment 3, the experiment of the influence of the medicine of the present invention for treating endometriosis on domestic rabbit endometriosis model

[0063] Adopt the medicine for the treatment of endometriosis prepared by embodiment 1 (clinical experiment is named after endometriosis), to the therapeutic effect test of endometriosis model rabbit, by contrast experiment, investigate medicine of the present invention to endometriosis Therapeutic effect of biting rabbits. The specific experimental process is as follows:

[0064] (1) Methods: 80 New Zealand rabbits were used to establish animal models of endometriosis by autologous endometrial pelvic transplantation. Intramuscularly inject estradiol benzoate (0.04ml / kg) 2 days before modeling, for a total of 2 days, inject pentobarbital sodium 30mg / kg intraperitoneally, perform laparotomy under sterile conditions after anesthesia, and ligate the mesentery For blood vessels, separate the right uterus to 2cm away from...

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Abstract

The invention relates to a drug used for treating endometriosis. The drug is prepared by the following raw materials by weight: 2.80-3.20 parts of pieplant, 2.80-3.20 parts of turtle shell, and 1.30-1.70 parts of amber. The invention discloses a method of producing the drug used for treating endometriosis. The drug has the functions of dissipating blood stasis and purging the bowels, is mainly used for treating endometriosis the indications of which are dysmenorrhea, pelvic pain, straining feeling in anus, sore waist and constipation, dark tongue or with ecchymosis, thin tongue coating, thready pulse or pulse string small. Compared with the western medicine danazol, the invention has similar clinical curative effects but with fewer adverse effects and can be easily accepted by patients.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a medicine for treating endometriosis and a preparation method thereof. Background technique [0002] Endometriosis is a common gynecological disease, but also a refractory disease. Can cause severe dysmenorrhea, pelvic pain, infertility and menstrual disorders. The incidence of endometriosis in the population is about 6-8%. The incidence rate is 2-22% in asymptomatic women, 40-60% in women with dysmenorrhea, 20-30% in infertile women, and about 10- Endometriosis was diagnosed postoperatively in 25% of patients. Since the etiology of endometriosis has not been fully elucidated so far, although there are many treatment methods, the effect is not very satisfactory. [0003] The uterus, also known as the woman's cell, was first recorded in the "Emperor's Internal Classic". Because the function is different from the zang-organs storing but not purging, and also diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/20A61P15/00A61K35/10
Inventor 王大增张军兵
Owner 北京羚锐伟业科技有限公司
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