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Medicine with protective function on gastric mucosa and liver injury and preparation method thereof

A technology for protection and liver damage, applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, it can solve rare problems and achieve the effects of calming medication, improving curative effect, and improving local blood circulation.

Active Publication Date: 2012-08-08
BEIJING WEIWEIKANG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] To sum up, there are few traditional Chinese medicines currently on the market that have a protective effect on gastric mucosa and liver damage.

Method used

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  • Medicine with protective function on gastric mucosa and liver injury and preparation method thereof
  • Medicine with protective function on gastric mucosa and liver injury and preparation method thereof
  • Medicine with protective function on gastric mucosa and liver injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the present invention has protective effect medicine preparation to gastric mucosa and liver injury

[0030] Drugs that have a protective effect on gastric mucosa and liver damage. The prescription of the traditional Chinese medicine is as follows: Baiji 3000g, Pueraria 1000g, Paeoniae Alba 1000g, Citrus aurantium 800g, Panax notoginseng 500g, licorice 500g

[0031] A method for preparing a drug with a protective effect on gastric mucosa and liver damage, comprising the following specific steps:

[0032] 1) Weigh the medicinal materials according to the components and their weights in the above-mentioned traditional Chinese medicine prescription, and perform routine pretreatment;

[0033] 2) Put the amount of Panax notoginseng in a multi-functional extraction tank, use 4 to 6 times the amount of 70% edible ethanol to heat and reflux for 1.5 hours for the first extraction, and use 3 to 5 times the amount of 70% edible ethanol for the second time Heat and r...

Embodiment 2

[0040] Embodiment 2, the experiment of the influence of the medicine that the present invention has protective effect on gastric mucosa and liver injury on rat liver injury model

[0041] Adopt the medicine that the gastric mucosa and hepatic injury that adopt embodiment 1 preparation have protective effect (clinical experiment name is Dingjiu oral liquid), carry out animal experiment to rat liver injury model, by contrast experiment, investigate the medicine of the present invention greatly to hepatic injury therapeutic effect in mice. The specific experimental process is as follows:

[0042] (1) Method: The alcoholic liver injury model was continuously given the mouse test substance for 30 days. At the end of giving the test sample, the model control group and each sample group were given 50% ethanol 12ml / kgBW by intragastric administration once, and the blank control group was given distilled water. , fasted for 16 hours to kill the animals, and the liver tissue was taken ...

Embodiment 3

[0071] Embodiment 3, the experiment of the influence of the medicine that the present invention has protective effect on gastric mucosa and liver injury to rat gastric mucosa injury model

[0072] Adopt the medicine that the gastric mucosa and hepatic injury of embodiment 1 preparation have protective effect (clinical experiment is named as Dingjiu oral liquid), to the therapeutic effect test of gastric mucosal injury rat, by contrast experiment, investigate the medicine of the present invention to gastric mucosa Therapeutic effects in injured rats. The specific experimental process is as follows:

[0073] (1) Method: The acute gastric mucosal injury model was administered to rats with the test substance continuously for 30 days, and the animals were fasted for 24 hours before dissection. On the day of the end of the experiment, the test substance was gavaged for 1 hour, and then 1.0ml of absolute ethanol was injected. After 1 hour, the animals were killed, and the stomach wa...

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Abstract

The invention relates to a medicine with protective function on gastric mucosa and liver injury. The medicine is prepared from the following raw materials in parts by weight: 2.80-6.20 parts of rhizoma bletillae, 0.80-4.20 parts of sanqi, 1.80-6.20 parts of vine root, 1.40-4.20 parts of immature bitter orange, 1.80-6.20 parts of white paeony root and 0.80-4.20 parts of liquorice. The invention also discloses a method for preparing the medicine with the protective function on gastric mucosa and liver injury. The medicine can make harmony of stomach, clear liver fire, enhance the immunity of the organism and improve local blood circulation, thus having higher value on health care of people. The medicine is used for patients with liver injury or gastric mucosa injury. Compared with the existing traditional Chinese medicine, the medicine has more remarkably curative effect, and the action of treating chemical liver injury and gastric mucosa injury is obviously superior to a control drug.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a medicine capable of protecting gastric mucosa and liver damage and a preparation method thereof. Background technique [0002] In the whole life activity, the human body must absorb nutrients from the outside world as the source of life activity energy to meet the needs of a series of metabolic activities such as human development, growth, reproduction, and tissue repair. The digestive system is an important system to ensure the normal progress of human metabolism. It is responsible for the intake and digestion of food, so that we can obtain nutrients such as carbohydrates, fats, proteins, and vitamins. Sexual digestion, absorb its nutrients, and excrete food residues from the body. Both the stomach and the liver belong to the digestive system, and they are closely related. [0003] The stomach is one of the most important digestive organs in the human body. Its i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P1/04A61P1/16
Inventor 曹春景
Owner BEIJING WEIWEIKANG TECH
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