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109 results about "Cholesterol absorption" patented technology

Managing cholesterol at the site of absorption is an increasingly popular strategy in the treatment of hypercholesterolemia [citation needed]. Cholesterol absorption inhibitors are known to have a synergistic effect when combined a class of antihyperlipidemics called statins, to achieve an overall serum

Composition for improving blood cholesterol levels

A nutritional composition for improving blood cholesterol by jointly and simultaneously inhibiting cholesterol absorption, decreasing blood LDL levels, increasing blood HDL levels and interfering with HMG-CoA reductase synthesis or degradation in an individual comprising, therapeutically effective amounts of plant sterols or plant stanols or derivatives thereof, procyanidins, policosanol and niacin or derivatives of niacin is provided. Both a composition and a method are provided by the present disclosure.
Owner:IOMEDIX DEV INT

Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders

The invention relates to compositions containing cholesterol absorption inhibitors alone or in combination with other therapeutic agents for treating non-alcoholic fatty liver disease-associated disorders by administering a therapeutically effective amount of the compositions to a subject in need thereof.
Owner:IRONWOOD PHARMA

Anti-hypercholesterolemic compounds

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
Owner:MERCK SHARP & DOHME CORP

Anti-hypercholesterolemic compounds

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
Owner:MERCK SHARP & DOHME LLC

Methods and apparatus for creating particle derivatives of HDL with reduced lipid content

ActiveUS20050004004A1Low in lipidsEnhancing cellular cholesterol effluxNervous disorderPeptide/protein ingredientsPresent methodCellular cholesterol
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
Owner:LIPID SCI +1

Anti-hypercholesterolemic biaryl azetidinone compounds

This invention provides cholesterol absorption inhibitors of Formula I:and the pharmaceutically acceptable salts thereof, wherein R12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of—OH and —COOH, and R9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.
Owner:MORRIELLO GREGORI J +1

Cholesterol absorption inhibitor

To provide a bacterium belonging to the genus Bifidobacterium which is excellent in a survival ability in the gastrointestinal tract, has an effect of inhibiting the cholesterol absorption in the intestinal tract, and is excellent in lipid metabolism ameliorating effects including decreasing the blood cholesterol level and the like, and shows a high survival rate after storage, and a cholesterol absorption inhibitor using the same. The invention provides a cholesterol absorption inhibitor containing, as an active ingredient, at least one microorganism selected from Bifidobacterium animalis subsp. animalis YIT 10394, Bifidobacterium animalis subsp. lactis JCM 1253, Bifidobacterium animalis subsp. lactis JCM 7117, and Bifidobacterium pseudolongum subsp. globosum.
Owner:YAKULT HONSHA KK

Methods and apparatus for creating particle derivatives of HDL with reduced lipid content

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
Owner:HDL THERAPEUTICS +1

Cholesterol lowering supplement

InactiveUS20050100619A1Preventing elevated blood cholesterol levelInhibiting cholesterol synthesisOrganic active ingredientsBiocidePlant stanolsElevated blood
The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as a suitable composition comprising (a) one or more phytosterols and / or phytostanols capable of reducing cholesterol absorption in the intestine and / or one or more soluble fibres capable of inhibiting ileal bile acid absorption, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions (b) and (c) is preferably derived from plants.
Owner:NUTRICIA

Selenium-rich natto product

The invention discloses a selenium-rich natto product, which comprises the following components in parts by weight: 35-50 parts of selenium-rich natto powder, 10-16 parts of phytosterol powder and 10-15 parts of green tea extract powder. The selenium-rich natto powder contains selenium natto kinase with high activity and long lasting time, and organic selenium, thus having an excellent antioxidation effect; phytosterol contained in the phytosterol powder has the effects of inhibiting cholesterol absorption of a human body, promoting katabolism of cholesterol, inhibiting biochemical synthesis of the cholesterol and the like; and catechinic acid contained in the green tea extract powder has the effects of inhibiting blood pressure and blood sugar, reducing cholesterol and low density lipoprotein in blood and increasing the content of high density lipoprotein. According to the selenium-rich natto product, the selenium-rich natto powder, the phytosterol powder and the green tea extract powder are combined in scientific proportion to take effect together in three aspects of inhibiting thrombus formation, improving thrombus dissolution and enhancing the toughness of blood vessels, and therefore, the selenium-rich natto product is capable of effectively preventing cardiovascular and cerebrovascular diseases.
Owner:GUANGZHOU CINJEP BIOTECH

Pharmaceutical Compositions and Process for Making Them

Amorphous HMG CoA reductase inhibitors, especially amorphous atorvastatin, are described. Also described are pharmaceutical combinations comprising amorphous HMG CoA reductase inhibitors in combination with cholesterol absorption inhibitors or fibrates. A method of manufacturing the compositions using a hot melt extrusion process are also described.
Owner:CIPLA LTD

Anti-hypercholesterolemic compounds

The instant invention provides novel cholesterol absorption inhibitors of Formula I and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
Owner:MERCK & CO INC

Vinegar drink with function of assistance on blood lipid reduction, and preparation method of vinegar drink

The invention discloses vinegar drink with a function of assistance on blood lipid reduction, and a preparation method of the vinegar drink. The vinegar drink is prepared from the following materials by weight percent: 20-30% of fermented yam vinegar, 15-20% of edible fungus enzymatic hydrolysate, 10-15% of kelp enzymatic hydrolysate, 5-8% of oyster enzymatic hydrolysate, 5-15% of fresh fruit and vegetable juices, 6-10% of functional oligosaccharide and the balance of water. The vinegar drink is obtained by microwave-assisted enzymolysis, stacked dynamic reflux fermentation, ultrafiltration membrane treatment and low-temperature centrifuging; the molecular weights of effective components are reduced by enzymolysis; effective matters are purified by membrane treatment, so that the matters are more easily absorbed by a human body, and the effect of assistance on blood lipid reduction is more easily exerted; a pasteuring way is adopted for sterilizing, so that nutritional ingredients are effectively prevented from being damaged by high temperature; the vinegar drink with the function of assistance on blood lipid reduction is rich in functional polysaccharide, the functional oligosaccharide, polypeptide, amino acid, fruit vinegar, vitamins and mineral substances, thus having the effects of reducing blood cholesterol and inhibiting cholesterol absorption, and having the function of assistance on blood lipid reduction; the vinegar drink also has the functions of scavenging free radicals and delaying human aging, and is beneficial to improving the immunity of the human body.
Owner:JIANGSU FOOD & PHARMA SCI COLLEGE

Sedum aizoon L. tea

The invention relates to Sedum aizoon L. tea, which is prepared by using the following raw materials in percentage by weight: 70 to 85 percent of Sedum aizoon L. leaves, 11 to 30 percent of aloe leaves, 3 to 15 percent of ginseng leaves and 3 to 15 percent of folium cortex eucommiae, optimally 76 percent of Sedum aizoon L. leaves, 18 percent of aloe leaves, 3 percent of ginseng leaves and 3 percent of folium cortex eucommiae. Sitosterol in the Sedum aizoon L. tea can prevent the cholesterol absorption of human bodies, reduce blood fat and prevent angiosclerosis; flavones in the Sedum aizoon L. tea can expand blood vessels, promote blood circulation and reduce myocardial oxygen consumption; and oleanolic acid in the Sedum aizoon L. tea can protect liver tissues and prevent liver fibrosis. The Sedum aizoon L. tea can be drunk for a long time for strengthening body, preventing arteriosclerosis and heart diseases, protecting the liver and delaying aging.
Owner:肖永英

A method for side effect reduction in the use of statins via physiologically synthesized glutathione

Embodiments of the present invention relate generally the use of certain compositions, e.g., compositions comprising a glutathione precursor and a selenium source, in the therapy of subjects suffering from diseases associated with hyperiipidemia and / or hypercholesterolemia. Related embodiments of the present invention relate to treatment and / or reducing the incidence of the side effects of statin therapy comprising administering to a subject in need, a composition comprising a glutathione precursor and a selenium source. Embodiments of the invention also relate to the use of the compositions in combination therapy with other agents such as statins, cholesterol absorption inhibitors, bile acid binding resins, or fibrates. In other embodiments, the invention relates to the use of such compositions comprising the glutathione precursor and the selenium source in the therapy of subjects suffering from erectile dysfunction and / or viral diseases such as Ebola virus disease (EVD) or Ebola hemorrhagic fever (EHF).
Owner:THE PROIMMUNE

Chinese medicine formula for treating hyperlipidemia

The invention discloses a Chinese medicine formula for treating hyperlipidemia, and relates to the technical field of traditional Chinese medicines. The Chinese medicine formula comprises the components: rhizoma alismatis, rhizoma polygonati, polygonum multiflorum, semen trigonellae, semen cassia, eucommia ulmoides, hawthorn, radix curcumae longae, lotus leaf, root of red-rooted salvia, black soya bean and Chinese-date. The Chinese medicine formula can be used as a Chinese medicine prescription, can be decocted to take orally, and can also be prepared into pills to take orally. The Chinese medicine formula disclosed by the invention is scientific and reasonable in combination, available in materials, simple in preparation method, short in course of treatment, and good in treatment effect; the Chinese medicine formula compounded by a plurality of medicines has the functions of promoting blood circulation to remove blood stasis, tonifying the liver and kidney, promoting blood circulation to remove meridian obstruction, reducing cholesterol absorption, and reducing blood fat, so as to achieve an effect of treating the hyperlipidemia. The effect of the Chinese medicine formula is significant in clinical application; the effective rate is 95.48%.
Owner:赵晶晶

Preparation method of nutritional barley seedling juice

The invention discloses a preparation method of nutritional barley seedling juice and belongs to the field of processing of foods. The preparation method of the barley seedling juice comprises the following steps: cutting barley seedlings, washing, sterilizing, fixing color, pulping, performing enzymolysis, filtering, homogenizing, fermenting, filling and preserving. According to the preparation method disclosed by the invention, an ozone sterilization method is adopted, so that inactivation of superoxide dismutase (SOD) in the barley seedling juice is reduced; the barley seedling juice is fermented by using lactobacillus, so that beneficial microorganisms in the seedling juice are greatly increased. The prepared barley seedling juice can simultaneously inhibit cholesterol absorption, reduce blood lipids, reduce blood pressure and enhance immunity and resistance of a human body; furthermore, vitamin C is added into the barley seedling juice after fermentation, thereby being conductive to activating and improving the enzyme activity of SOD, which is improved by 45% in comparison with the enzyme activity of SOD before adding the vitamin C and having the effects of resisting aging and promoting longevity; and furthermore, the original grass smell in the barley seedlings is reduced and the product is slightly fragrant, thereby having broad market potentials.
Owner:天津北洋百川生物技术有限公司

Blood fat lowering mung bean cake

The present invention relates to a blood fat lowering mung bean cake. The preparation comprises: grinding mung bean into mung bean powder, spreading the mung bean powder, drying, crushing hawthorn, plantaginis semen shell, brown algae and salvia miltiorrhiza, placing the crushed materials into a leaching tank, carrying out dipping and boiling to obtain a leaching liquid, mixing the leaching liquid and the mung bean powder, adding lactase, carrying out constant temperature enzymolysis to obtain an enzymolysis product, adding Sa-son seed gum, uniformly stirring, dividing into small blocks, placing into a steaming drawer to steam, and carrying out cooling solidification. According to the present invention, with the blood fat lowering mung bean cake, the cholesterol absorption of the intestinal tract is inhibited, the enterocinesia is promoted, the fat oxidation decomposition is accelerated, and the cholesterol excretion rate is increased so as to reduce the cholesterol content in the blood; the preparation process is simple and easy to perform, and the obtained blood fat lowering mung bean cake has characteristics of delicate and fragrant taste, soft and smooth hand-feeling, no hard block and easy digestion and absorption, is suitable for people with pool stomach and pool spleen, is rich in polysaccharides, proteins, vitamins, mineral elements and cellulose, and further has high nutritional values and health functions.
Owner:ANHUI HONGTAI FOOD

Simulated lactic acid bacterium flavored vegetarian sausage

The present invention relates to a simulated lactic acid bacterium flavored vegetarian sausage. The vegetarian sausage mainly comprises the following components: textured soybean proteins, water, soybean oil and lactic acid bacteria. The simulated lactic acid bacterium flavored vegetarian sausage is prepared by vegetarian meat stirring, compound ingredient stirring, lactic acid bacterium inoculating, fermenting, sausage filling, shaping and cooking, cooling and sausage casing stripping, vacuum packaging, and sterilizing. The proteins of soybeans in the prepared simulated lactic acid bacterium flavored vegetarian sausage contains isoflavones, the lactic acid bacteria promote absorptions of nutrients of proteins, monosaccharide, calcium, magnesium, etc., and the vegetarian sausage produces a large amount of beneficial substances of vitamin B groups, etc., inhibits cholesterol absorption, lowers blood lipids and blood pressure, has good chewiness, is rich in flavor and full and life-like in appearance, and has shape characteristics of meat products of the sausages.
Owner:深圳齐善食品有限公司

NPC1L1 (NPC3) and methods of use thereof

InactiveUS7135556B2BacteriaPeptide/protein ingredientsCholesterol bindingCholesterol absorption
We claim an isolated polypeptide having ability of binding with cholesterol. Said polypeptide is useful for investigating regulation of intestinal cholesterol absorption and cholesterol levels. Also, we claim a composition comprising said polypeptide bound to cholesterol or ezetimibe and a fusion protein comprising the polypeptide thereof.
Owner:MERCK SHARP & DOHME CORP

Jiangzhining granule and preparation method thereof

The invention discloses a Jiangzhining granule. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 25 to 27.5 parts of hawthorn, 1 to 1.25 parts of radix polygonum multiflorum preparata, 1 to 1.25 parts of semen cassiae and 3.25 to 3.75 parts of lotus leaves. The prepared Jiangzhining granule has functions of expanding coronary vessels, increasing coronary flow, reducing cholesterol absorption, accelerating cholesterol excretion, inhibiting the rising of serum cholesterol and the formation of atherosclerotic plaques, reducing blood fat and cholesterol and the like.
Owner:TONGHUA XINDONGRI PHARMA CO LTD

Combinations of MTP Inhibitors with Cholesterol Absorption Inhibitors or Interferon for Treating Hepatitis C

InactiveUS20100226886A1Reduction in hepatitis C viral loadShort treatment timeBiocidePeptide/protein ingredientsActive agentMicrosomal triglyceride transfer protein
The invention is directed in part to methods for treating and / or controlling hepatitis C in a patient. The methods are directed in part to combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for example, AEGR-733 and implitapide) and at least one other active agent.
Owner:AEGERION PHARM INC

Medicine composition containing lipoprotein-associated phospholipase A2 inhibitors and application thereof

ActiveCN104840963APharmaceutical active ingredientsCardiovascular disorderLipoprotein-associated phospholipase A2Triglyceride metabolism
The invention relates to a medicine composition containing lipoprotein-associated phospholipase A2 inhibitors and application of the medicine composition, and belongs to the technical field of medicine. The medicine composition consists of lipoprotein-associated phospholipase A2 inhibitors and one or several kinds of the following ingredients including HMG-CoA (3-hydroxyl-3-methylglutaryl CoA) reductase inhibitors, cholesterol and triglyceride metabolism influence medicine, cholesterol absorption influence medicine, polysaccharide lipid-lowering medicine, gastrointestinal lipase inhibitors or butylphenyl phthaleine. The medicine composition provided by the invention has the surprising curative effect in the aspect of treating atherosclerotic diseases, and the surprising curative effect cannot be achieved by previous lipid-lowering medicine.
Owner:HEBEI DONGKANG BIOTECH CO LTD

Astaxanthin-containing healthcare noodles and preparation method thereof

The invention discloses astaxanthin-containing healthcare noodles and a preparation method thereof. An active ingredient of the astaxanthin-containing healthcare noodles is prepared from wheat flour, astaxanthin powder, hawthorn, malt, egg, chitosan, Artemisia seed glue, edible salt and Chinese herbal medicine additive. The Chinese herbal medicine additive is prepared from bamboo fungus, phlomis mongolica, kelp, semen cassia, bamboo leaf, chickpea, fructus perillae, momordica grosvenori, inula flower, radix astragali and trichosanthes kirilowii. Astaxanthin has efficacy of lowering blood fat, preventing cardiovascular diease, inhibiting diabetic nephropathy and enhancing immunity and is combined with Chinese herbal medicine having efficacy of clearing liver heat, tranquilizing liver yang, nourishing liver and kidney, moistening dryness to promote salivation, tonifying spleen and qi, activating blood to remove stasis, eliminating phlegm and inducing dieresis, and various raw materials are matched and composed scientifically, thereby balancing both symptoms and root causes and being safe, reliable and remarkable in treatment effect; synergistic or resistant effect among the raw materials is utilized to improve treatment effect, so that effects of reducing cholesterol absorption, accelerating cholesterol discharge and lowering blood fat are realized, and a healthy food is provided for patients with hyperlipidemia and hyperglycemia.
Owner:山东海葵生物科技有限公司
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