The invention discloses a centrally symmetrical round pipe positioning device, which comprises a bottom positioning die, an upper pressing die, a left V-shaped block, a right V-shaped block, a left-handed nut slider, a right-handed nut slider and a two-way lead screw , the upper pressing die is arranged directly above the bottom positioning die, the left V-shaped block and the right V-shaped block are symmetrically arranged on the left and right sides of the bottom positioning die, and the left-handed nut slider is arranged on the left V-shaped block Below, the right-handed screw nut slider is arranged below the right V-shaped block, and the two-way lead screw penetrates from one end of the left-handed screw nut slider and then passes out from the other end of the right-handed screw nut slider. Through the above method, the centrosymmetric round pipe positioning device of the present invention can perform positioning and clamping from four directions of the round pipe, and has the advantages of accurate and reliable positioning, uniform clamping force, simple structure and convenient manufacture, and is suitable for many Positioning and clamping of circular tubes of different diameters.