31 results about "Biological phenomenon" patented technology

A method of photoplethysmography includes processing a signal (46;56) based on at least one signal (35;50) from at least one sensor (5;18-20;26;63) arranged to capture light from a living subject to extract information on a characteristic of a periodic biological phenomenon. At least one of the signals (35;50) from at least one sensor (5;18-20;26;63) is obtained by using at least one of a light sensor (1;11-13) and a filter (6;17;64) placed before the at least one sensor (5;18-20;26;63) tuned to a peak in an absorption spectrum of water.

An improved microfluidic device and method of using the microfluidic device to measure natural motile response of a living moiety to a chemotactic agent. The invention comprises integrating microfluidic containment trenches within the microfluidic devices for cellular trapping, manipulation and real-time analysis of biological phenomena, including chemotaxis. The invention captures the design methodology for these traps, as well as the fabrication means and the associated external control mechanism that allows rapid, reversible and fully controlled changes in the chemical environment to which trapped cells are exposed.

A method of photoplethysmography includes processing a signal (46; 56) based on at least one signal (35; 50) from at least one sensor (5; 18-20; 26; 63) arranged to capture light from a living subject to extract information on a characteristic of a periodic biological phenomenon. At least one of the signals (35; 50) from at least one sensor (5; 18-20; 26; 63) is obtained by using at least one of a light source (1; 11- 13) and a filter (6; 17; 64) placed before the at least one sensor (5; 18-20; 26; 63) tuned to a peak in an absorption spectrum of water.

The invention discloses a bionic object selection method based on a TRIZ theory. The method is characterized in comprising the following steps of: S1: converting an engineering practical problem into a TRIZ problem, and extracting a parameter to be improved and a deteriorated parameter; S2: independently substituting the parameter to be improved and the deteriorated parameter into an Altshuller contradiction matrix to search recommended inventive principles for solving a problem; S3: in the obtained inventive principles, analyzing the occurrence frequency of each inventive principle, sorting the inventive principles according to the descending order of the occurrence frequency, and selecting the inventive principles which are in the top N rank; and S4: comparing the inventive principles with a bionic phenomenon, selecting a biological phenomenon which is most suitable for solving the problem as a model to determine the bionic object. By use of the method, an advanced inventive problem solution, i.e., the TRIZ theory, can be introduced into a traditional bionic object selection process, the TRIZ theory is used for guiding the selection of a bionic biological prototype, and the bionic object which is most suitable for solving the problem can be efficiently selected.

Detection sequences of periostin having from 6 to 30 amino acids and which include all or part of peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3, or a homologous peptide sequence. Antibodies suitable for specifically recognizing minimally one of these detection sequences, including an anti-periostin antibody, are disclosed. Periostin detection and dosage processes and kits that use these antibodies are also disclosed. A periostin marker for early diagnosis, tracking and prognosis of pathologies that involve periostin, including benign osteolysis such as inflammatory diseases, including osteoarticular diseases, and malignant osteolysis, such as cancers with bone metastases, is provided.

It is intended to provide a means of quickly clarifying the dynamics and molecular mechanism of a biological phenomenon by, at least in a single cell, enabling the convenient and quick detection of molecules in a fluid contained in the cell and simultaneously observing the cell dynamics. At the same time, it is aimed at providing a means of searching for an active molecule providing a certain state of a cell from among a number of the detected molecules. The fluid contained in a single cell is directly sucked through a capillary and then loaded directly on an analyzer. This procedure is carried out under a magnifying glass such as a microscope while observing the cell. In the case of employing mass spectrometry, in particular, the fluid contained in the cell is captured by directly sucking through an ionization capillary for a nano-spray, mixed with an ionization-assisting solvent, and then directly introduced into a mass spectrometer by the direct spraying method. Thus, the molecular components of the inner fluid are detected even from a single cell. By analyzing the thus captured molecular peaks among cell data groups in different states with the use of differential analysis or t-calibration, a peak, i.e., a molecule that is specific to a certain state is identified.

A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.

Mucositis is the result of a complex process of interactive biologic phenomena that take place in both the epitelium and the submucosa, often leading to severe pain and increased risk of dangerous syste f48 mic infections. Mucositis is often a side effect during chemotherapy and radiation therapy. The benzamidine derivatives herein described are particularly effective for treating and preventing mucositis since they are acting simultaneously at the several phases that characterize this disease. Data supplied from the esp@cenet database

The invention provides a single-cell ATAC-seq data analysis method. The single-cell ATAC-seq data analysis method comprises the following steps: S1, performing data analysis and quality control on sequencing original data; S2, performing comparative analysis; S3, analyzing an insertion fragment; S4, carrying out Peak analysis on the enrichment region; S5, classifying the single-cell subgroups; S6,carrying out annotation and enrichment on the Peak related genes; S7, carrying out TF-motif analysis; S8, carrying out the subgroup accessibility difference analysis; S9, analyzing related genes of the difference accessibility sites, and annotating genes corresponding to the transcription start sites closest to the peak region where the identified difference TF-motif is located, and the like. According to the method, a comprehensive single-cell ATAC-seq data analysis process with rich analysis contents is constructed; the analysis result reveals a large amount of biological information, people can deeply excavate biological phenomena and characteristics contained in the single-cell level conveniently, the analysis process and result are visually displayed in the form of html, the analysiscontent is clear in hierarchy, the result display forms are diversified, and the readability of the report is improved.

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34cdc2-cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.

The invention discloses application of trans-cucurbit(7)uril in recognition of biogenic amines. Trans-cucurbit(7)uril can be used for recognizing tryptamine by the following steps: (a) adding trans-cucurbit(7)uril into a nuclear magnetism tube, adding D2O, and vibrating to dissolve, so as to obtain a product A; (b) storing tryptamine into a frozen storage pipe, adding D2O to dissolve, so as to obtain a product B; and (c) successively adding the product B into the product A so as to obtain a corresponding nuclear magnetism spectrogram in each dropwise adding process until a series of nuclear magnetism spectrograms of a host-guest complex, making comparison on the nuclear magnetism spectrograms and a nuclear magnetism spectrogram of tryptamine, and determining biogenic amines as tryptamine when two groups of signal peaks Hg and Hf appear in the spectrograms, Hgs move towards a low field, Hfs move to a high field, peak forms of signal peaks of other Ha-He protons are widened and signal peaks move towards the high yield. Trans-cucurbit(7)uril can be used for recognizing six biogenic amines including tryptamine, spermine, spermidine, tyramine and phenylethylamine and is of a great significance to reveal of biological phenomena and processes.

The present invention provides data analysis methods for the rapid location of subsets of large, multivariable biological datasets that are of most interest for further analysis, for the investigation of molecular modes of action of biological phenomena of interest, and for the identification of sets of data points that best distinguish between experimental groups in larger datasets as putative biomarkers. While existing methods for analyzing large biological datasets generally provide too much information to the user, or not enough, the methods of the present invention entail taking user input on what kinds of trends are of interest and then finding results that match the designated trend. In such manner, the methods of the invention allow a user to quickly pinpoint the subset of data of most interest without a concomitant loss of a large percentage of relevant information, as is typical with standard methods. The methods of the invention allow for identification of molecular entities that are involved in a biological phenomenon of interest, entities that may have otherwise gone undiscovered in a large, multivariable dataset.

A genomic variant analysis method and computer system utilizing information related to variant frequency and biological consequence to determine the relative statistical significance of each variant in given genome sequence datasets. The method and system perform both variant frequency normalization and universal pairwise variant comparisons across the given genome sequence datasets to automatically identify the likelihood of any given variant as contributing to disease process or biological phenomenon under study and organize the results into a priority ranking. The priority ranking is then used to categorize the results into biologically-related data subsets for display to indicate potential for importance.

A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.

The invention discloses application of trans-cucurbiturils iQ[7] and a preparation method. The trans-cucurbiturils iQ[7] can be used for recognizing lysine, arginine or histidine. The trans-cucurbiturils iQ[7] can effectively recognize lysine, arginine and histidine of 10 amino acids essential for human bodies, has great significances in revealing biological phenomena and process, and has wide application prospects.

Detection sequences of periostin having from 6 to 30 amino acids and which include all or part of peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3, or a homologous peptide sequence. Antibodies suitable for specifically recognizing minimally one of these detection sequences, including an anti-periostin antibody, are disclosed. Periostin detection and dosage processes and kits that use these antibodies are also disclosed. A periostin marker for early diagnosis, tracking and prognosis of pathologies that involve periostin, including benign osteolysis such as inflammatory diseases, including osteoarticular diseases, and malignant osteolysis, such as cancers with bone metastases, is provided.

The disclosed approach employs a generic methodology for transforming individual modality specific multi-parametric data into data, e.g., maps or images, which provides direct insight into the underlying physiology of the tissue. This may facilitate better clinical evaluation of the disease data as well as help non-imaging technologists and scientist to directly correlate imaging findings with basic biological phenomenon being studied with imaging.

A method of photoplethysmography includes processing a signal based on at least one signal from at least one sensor arranged to capture light from a living subject to extract information on a characteristic of a periodic biological phenomenon. At least one of the signals from at least one sensor is obtained via sensing radiation as to a peak in an absorption spectrum of water.

The invention relates to a multi-channel mechanical damaging device which is used for damaging cells and which comprises a pin support body 1, a plurality of pins 2 which are arranged in parallel and connected with the pin support body, and a handle which is connected with the pin support body; the length the pins extending out of the pin support body can be adjusted. The pin support body is provided with a plurality of holes 5; the pins can be inserted into the holes and are suitable for the one-time suction head which can be replaced. The multi-channel mechanical damaging device can also be provided with guide components 4 which are arranged on two sides of the pin support body 1; and the angle between the guide components can be regulated. In particular, the invention provides an 8-channel mechanical damaging device which can be used in the cell injury experiment of cells which are cultured by 96-hole microplate. The invention also provides a method which uses the multi-channel mechanical damaging device to damage the cell culture and an application thereof in cell migration and the potential biological phenomena thereof.

Provided herein is a method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method including the steps of providing first data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon, providing a numerical model, converting the first data into at least one point on the same Riemann manifold, and using a numerical model to determine a temporal progression for the biological phenomenon for the studied subject, the numerical model being a function in a Riemann manifold, the numerical model associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers.

The invention discloses application of trans-cucurbit(7)uril in recognition of biogenic amines. Trans-cucurbit(7)uril can be used for recognizing tryptamine by the following steps: (a) adding trans-cucurbit(7)uril into a nuclear magnetism tube, adding D2O, and vibrating to dissolve, so as to obtain a product A; (b) storing tryptamine into a frozen storage pipe, adding D2O to dissolve, so as to obtain a product B; and (c) successively adding the product B into the product A so as to obtain a corresponding nuclear magnetism spectrogram in each dropwise adding process until a series of nuclear magnetism spectrograms of a host-guest complex, making comparison on the nuclear magnetism spectrograms and a nuclear magnetism spectrogram of tryptamine, and determining biogenic amines as tryptamine when two groups of signal peaks Hg and Hf appear in the spectrograms, Hgs move towards a low field, Hfs move to a high field, peak forms of signal peaks of other Ha-He protons are widened and signal peaks move towards the high yield. Trans-cucurbit(7)uril can be used for recognizing six biogenic amines including tryptamine, spermine, spermidine, tyramine and phenylethylamine and is of a great significance to reveal of biological phenomena and processes.

The invention provides a fast fire-extinguishing ashtray which is designed by virtue of a biological phenomenon of water-absorbing and fire-extinguishing through a frog mouth. In the invention, water in a transparent cup is communicated with the outlet of the tail of a frog so as to facilitate watering and extinguishing smoke and fire.

The invention discloses a plant pollen development specific promoter and an application thereof. The promoter has a full length of 1140 bases, and is used for starting gene expression at the plant pollen mononuclear microspore phase and at the matured pollen grain phase, wherein the expression is only carried out in tapetal layers and pollen. The promoter has good application prospects on genetic engineering breeding, is helpful for understanding biological phenomena of pollen development and male sterility, provides a new regulatory element for plant male sterility genetic engineering, and provides theoretical basis and application guidance for effective control of plant fertility performance, and rapid acquisition of production-available male sterile lines.

The invention provides a microfluidic chemotactic chip, and further provides a water eutrophication indication method based on the microfluidic chemotactic chip. The microfluidic chemotactic chip is composed of three units of the nutrient water gradient forming unit, the cell sample-injecting unit and a chemotactic effect observation chamber. The nutrient water gradient forming unit can form one of a nutrient water linear source gradient or a nutrient water point source gradient. The cell sample-injecting unit is arranged at the corresponding position according to the gradient forming mode. The microfluidic chemotactic chip has the following beneficial effects that the microfluidic chemotactic chip can accurately simulate the nutrient water linear source gradient and the nutrient water point source gradient, and a friendly testing platform is provided for chemotaxis of microalgae and bacteria to nutrient substances; and the eutrophication degree of water is evaluated from the aspect ofthe biological phenomenon instead of exploration of a physicochemical environment, the more convenient and intuitive effects are achieved, and thus supplement is provided for an existing eutrophication evaluation method based on exploration of the physicochemical environment.

Provided herein is a method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method including the steps of providing first data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon, providing a numerical model, converting the first data into at least one point on the same Riemann manifold, and using a numerical model to determine a temporal progression for the biological phenomenon for the studied subject, the numerical model being a function in a Riemann manifold, the numerical model associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers.

The invention relates to a multi-channel mechanical damaging device which is used for damaging cells and which comprises a pin support body 1, a plurality of pins 2 which are arranged in parallel and connected with the pin support body, and a handle which is connected with the pin support body; the length the pins extending out of the pin support body can be adjusted. The pin support body is provided with a plurality of holes 5; the pins can be inserted into the holes and are suitable for the one-time suction head which can be replaced. The multi-channel mechanical damaging device can also be provided with guide components 4 which are arranged on two sides of the pin support body 1; and the angle between the guide components can be regulated. In particular, the invention provides an 8-channel mechanical damaging device which can be used in the cell injury experiment of cells which are cultured by 96-hole microplate. The invention also provides a method which uses the multi-channel mechanical damaging device to damage the cell culture and an application thereof in cell migration and the potential biological phenomena thereof.

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34cdc2-cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.