51 results about "Aromatic hydroxylation" patented technology

An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention provides an isocyanate production process including the steps of: obtaining a reaction mixture containing an aryl carbamate having an aryl group originating in a diaryl carbonate, an aromatic hydroxy compound originating in a diaryl carbonate, and a diaryl carbonate, by reacting a diaryl carbonate and an amine compound in the presence of a reaction solvent in the form of an aromatic hydroxy compound; transferring the reaction mixture to a thermal decomposition reaction vessel; and obtaining isocyanate by applying the aryl carbamate to a thermal decomposition reaction, wherein the reaction vessel in which the reaction between the diaryl carbonate and the amine compound is carried out and the thermal decomposition reaction vessel for the aryl carbamate are different.

A water dilutable binder resin for use in an inorganic fiber material; wherein the binder resin is prepared by reacting at least the following components in any order: (a) proteinaceous material which is substantially soluble in water at 20° C. and has a viscosity of <50 mPa*s for a 25 wt % aqueous solution, (b) an aromatic hydroxyl compound, and (c) an aldehyde, and wherein the water dilutable binder resin has a property of having a viscosity of <100 mPa*s when measured at a concentration of 50 wt % at 20° C. During curing, the resin thus produced gives lower phenol emissions. Also, the formaldehyde and ammonia emissions are dramatically lower when compared to conventional resins.

A negative photosensitive resin composition including an alkali-soluble resin (A), a photoacid generator (B), a basic compound (C), a cross-linking agent (D), and a solvent (E) is provided. The alkali-soluble resin (A) includes an acrylate resin (A-1) and a novolac resin (A-2). The acrylate resin (A-1) is synthesized by polymerizing a monomer for polymerization, wherein the monomer for polymerization includes an unsaturated carboxylic acid or unsaturated carboxylic acid anhydride monomer (a-1-1) and a monomer (a-1-2). The monomer (a-1-2) includes a compound (a-1-2-1) with a tricyclodecane or dicyclopentadiene structure, a compound (a-1-2-2) represented by formula (1), or a combination of both. The novolac resin (A-2) is synthesized by polymerizing an aldehyde compound with an aromatic hydroxy compound, wherein the aromatic hydroxy compound includes a xylenol compound.

An air cleaner, wherein an inlet port and an outlet port are formed, an antiallergic filter having an aromatic hydroxyl compound is installed in the air flow passage of an air blow means in a body, and the inlet port is formed at the front lower part of the air cleaner, whereby pollen and dead tick near a floor surface can be efficiently sucked to inactivate antiallergic activation. A treating solution is conditioned by dissolving and / or dispersing a water soluble material and a water insoluble material in the mixed solvent of water, celosolves and / or carbitols. A functional filter can be manufactured by adding the treatment solution to a filter base material. An air cleaner device is formed by disposing the functional filter between the inlet port and the outlet port for air or water. An air cleaning filter is formed by adding two or more raw materials selected from a raw material having antiallergic properties, a raw material having antibacterial properties, a raw material having antivirus properties, and a raw material having mildewproofing properties. The air cleaning device is formed by disposing the air cleaning filter between the inlet port and the outlet port for air.

The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite.

A method for preparing 1,1,1,-tris(4-hydroxyphenyl)alkanes generally comprises reacting a mixture of an aromatic hydroxy compound and a ketone in the presence of at least one ion exchange resin catalyst and optionally a co-catalyst to produce the 1,1,1-tris(4-hydroxyphenyl)alkanes of formula:

The present invention relates to a positive photosensitive resin composition and a method for forming patterns by using the same. The positive photosensitive resin composition includes a novolac resin (A), an ortho-naphthoquinone diazide sulfonic acid ester (B), a hydroxycompound (C) and a solvent (D). The novolac resin (A) further includes a hydroxy-type novolac resin (A-1) and a xylenol-type novolac resin (A-2). The hydroxy-type novolac resin (A-1) is synthesized by condensing hydroxyl benzaldehyde compound with aromatic hydroxyl compound. The xylenol-type novolac resin (A-2) is synthesized by condensing aldehyde compound with xylenol compound. The postbaked positive photosensitive resin composition can be beneficially formed to patterns with high film thickness and well cross-sectional profile.

The invention relates to a positive photosensitive resin composite and a method for forming a pattern and especially to a positive photosensitive resin composite having good anti-cracking performance and a method for using the composite to form the pattern. The positive photosensitive resin composite contains novolac resin (A), epoxy resin (B) having epoxy propyl, naphthoquinone sulfoacid ester (C) and solvent (D), wherein the novolac resin (A) contains hydroxy novolac resin (A-1). The hydroxy novolac resin (A-1) is prepared by condensing hydroxy benzaldehyde compound and aromatic hydroxyl compound.

The present invention relates to a continuous method for the preparation of an aromatic carbonate by reacting a dialkyl carbonate and an aromatic hydroxy compound in the presence of a heterogeneous catalyst, and a reaction apparatus for the same. The continuous method comprises the step of reacting dialkyl carbonate and an aromatic hydroxy compound in the presence of the heterogeneous catalyst in a loop-type, catalyst-containing reaction apparatus, wherein a reactor equipped with a filter in which the catalyst is contained is connected with a heat exchanger portion for providing necessary heat during the reaction, reaction solution is circulated between the catalyst-containing portion and heat exchanger via a circulation pump, and by-products can be eliminated via a distillation column connected with the reactor.

Resin compositions (A) and (B) are described: wherein resin composition (A) comprises a naturally occurring component or derivative thereof comprising protein, an aromatic hydroxyl compound-aldehyde resin and an amino resin, wherein the naturally occurring component or derivative thereof is chemically bound to the aromatic hydroxyl compound-aldehyde resin to form an ncPF resin and the naturally occurring component or derivative thereof is optionally chemically bound to the amino resin; wherein resin composition (B) comprises a condensation product of a naturally occurring component or derivative thereof, an aromatic hydroxyl compound-aldehyde resin and at least 20 wt % of urea based on the total mass of the resin composition, wherein at least 50 wt % of the naturally occurring component or derivative thereof is chemically bound directly or indirectly to the aromatic hydroxyl compound-aldehyde resin (ncPF), and wherein the naturally occurring component or derivative thereof comprises protein. The resin compositions can be used as a binder for lignocellulosic or cellulosic materials which have an excellent combination of low formaldehyde emissions and high strength. Also described are low formaldehyde emissions wood products comprising unique binder combinations.