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30 results about "Allergen specific IgE" patented technology
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Microarray chip for detection of immunoglobulin
InactiveUS20060008895A1Determine hypersensitivity levelTime-effectiveBioreactor/fermenter combinationsSequential/parallel process reactionsTotal igeSpecific igm
Disclosed is a microarray chip for allergy-related immunoglobulin detection, especially for quantitative detection of total IgE and allergen-specific immunoglobulins (such as specific IgE, specific IgG, and specific IgM), which comprises a solid substrate, a reactive layer fabricated on the solid substrate, and at least one allergen or substance capable of binding to immunoglobulin of interest. Whereby, use the result of quantitative detection for allergen-specific IgE to determine hypersensitivity level. In addition, a method for allergy-related immunoglobulin detection using the microarray chip is present, which uses a secondary monoclonal antibody to minimize non-specific binding and applies an enzymatic reaction to amplify reaction signal. An efficient way is thus obtained, which not only reduces time consumption but also provides quantitative measurement.
Owner:CHENG LOONG CORPORATION
Methods For Characterizing Antibody Binding Affinity And Epitope Diversity in Food Allergy
ActiveUS20110071043A1High affinityPeptide librariesPeptide/protein ingredientsEpitope mappingFood allergy
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects, methods are provided for the specific characterization of IgE and IgG4. Also disclosed are methods for diagnosing whether a milk-allergic individual will outgrow his or her allergy based on the characterization of the individual's milk allergen-specific IgE antibodies.
Owner:MT SINAI SCHOOL OF MEDICINE
Methods for characterizing antibody binding affinity and epitope diversity in food allergy
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects, methods are provided for the specific characterization of IgE and IgG4. Also disclosed are methods for diagnosing whether a milk-allergic individual will outgrow his or her allergy based on the characterization of the individual's milk allergen-specific IgE antibodies.
Owner:MT SINAI SCHOOL OF MEDICINE
Liquid phase chip for detecting allergen specific antibody and preparation method of liquid phase chip
ActiveCN103454412AComprehensive clinical testingAccurate clinical detection meansFluorescence/phosphorescenceBiotin-streptavidin complexFluorescence
The invention discloses a liquid phase chip for detecting an allergen specific antibody. The liquid phase chip mainly comprises (1) a plurality of common allergen probes, comprising 12 fluorescence coded microspheres respectively coated with mite, cockroach, ragweed, felon herb, dog hairs, cat hairs, soybean, peanut, milk, egg, shrimp and crab allergen extracts; (2) a biotin labeling detection antibody; (3) a streptavidin phycoerythrin; (4) a total IgE (immunoglobulin E) probe used when semiquantitative or quantitative detection is carried out on the allergen specific IgE antibody, namely, a fluorescence coded microsphere coated with a rat anti-human IgE monoclonal antibody. The invention also discloses a preparation method of the liquid phase chip probe. The liquid phase chip disclosed by the invention is mainly used for detecting the allergen specific IgE antibody in a serum sample, also for detecting an allergen specific IgG4 (Intravenous Gamma Globulin 4) antibody and a total IgE antibody, and has the advantages of few used samples, parallel detection of a plurality of indexes, high flux, high sensitivity and the like.
Owner:NANJING BOMINDA BIO TECH
Rapid specific antibody IgE detection kit and preparation method thereof
The present invention relates to a rapid allergic disease allergen diagnosis kit through a two-step method, a preparation method and a use method thereof. During use of the kit, a serum sample requiring detection and catalase-labeled allergen are subjected to equal volume mixing, room temperature incubation is performed for 5-15 min, the mixed sample is added to a sample hole of colloidal gold test paper strip, and the result is read after 5-15 min, wherein the test strip comprises the sample hole, a colloidal gold pad, a film strip and a water suction pad, colloidal gold is conjugated with biotin labeled goat anti-catalase antibody through streptomycin protein and mouse anti-human IgE monoclonal antibody is coated on the film strip so as to form the colloidal gold-streptomycin protein-biotin-goat anti-catalase antibody-catalase-allergen-specific human IgE antibody-mouse anti-human IgE antibody complex, and the quality control zone is coated with mouse anti-goat IgG antibody. The total detection time of the kit is 10-30 min. The kit has characteristics of strong specificity, high sensitivity, simpleness, rapidness, on-site inspection and no requirement of professional training on operators, wherein operations on allergen specific IgE detection reagents can be completed according to the instruction.
Owner:北京新华联协和药业有限责任公司
Kit and method for achieving highly-sensitive multiterm joint inspection of allergen-specific IgE antibodies
InactiveCN105044326AReduce dosageSuitable for high-throughput detectionMaterial analysisSerum igePolymerase L
The invention discloses a kit and method for achieving highly-sensitive multiterm joint inspection of allergen-specific IgE antibodies. The kit comprises a membrane strip, the polymerase coupling anti-human IgE antibodies and a substrate color development agent matched with the polymerase coupling anti-human IgE antibodies; str-bio-allergens are fixed on the membrane strip, and the allergen-specific IgE antibodies are detected by adopting the kit. In this way, According to the kit and method for achieving highly-sensitive multiterm joint inspection of the allergen-specific IgE antibodies, the concentration of the allergen-specific antibodies IgE in the human serum or plasma can be detected highly sensitively, qualitatively or semi-quantitatively and quickly, the allergen usage amount can be reduced, dozens of allergens can be screened for one time, the advantages of being quick, accurate and little in sample usage amount are achieved, and high throughput detection is suitably performed.
Owner:SUZHOU HAOOUBO BIOPHARML
Herbal composition for treating allergic disorders and method for making the same
Pharmaceutical compositions for treating immunological disorders and the preparing method of the same are disclosed, which include alcohol extracts of Radix Dioscorea, Rhizoma Alismatis, Poria cocos (schw) Wolf, and Scutellaria Baicalensis. The compositions are manufactured by novel procedures consisting of decocting using specific concentration ranges of alcohol, filtering, regulating pH value, purifying, concentrating, proportionally mixing, and making a granule powder from lyophilized extract. This invention used both in vitro and in vivo assays to evaluate therapeutic effects of specific combination of herbal plant extracts. The combination of herbal extracts has been able to maximize the anti-inflammatory activity and regulate the secretion of cytokines such as eotaxin and IL-4. When the pharmaceutical composition of the present invention is used for asthma, it can relieve coughs, resist airway allergic inflammation reactions, improve the pulmonary functions, reduce allergen specific IgE in bloods, stabilize elasmatoblasts, and stop the attacks from asthma.
Owner:IND TECH RES INST
Surface acoustic wave immunosensor for diagnosing allergy disease and method for diagnosing allergy disease using the same
InactiveUS20090280509A1Effectively diagnosing allergy diseaseBioreactor/fermenter combinationsMaterial analysis using sonic/ultrasonic/infrasonic wavesAcoustic waveSurface acoustic wave
A surface acoustic wave (SAW) immunosensor for diagnosing allergy disease includes one or more SAW devices on each of which allergens derived from one allergy-causing substance are fixed and an allergen derived from another allergy-causing substance is not included, that is, allergens derived from different allergy-causing substances being fixed on different SAW devices; and a signal detector which detects an output signal from the SAW device. Also a method for diagnosing allergy disease is capable of measuring levels of allergen-specific IgE and total IgE in blood or another sample taken from a subject of diagnosis using a SAW immunosensor, the allergens being derived from various allergy-causing substances, thereby capable of effectively diagnosing allergy disease for various allergy-causing substances.
Owner:SAMSUNG ELECTRONICS CO LTD
Kit detecting dog-hair allergen specific IgE antibody and method
InactiveCN105353134AImprove stabilityStrong specificityChemiluminescene/bioluminescenceBiological testingBiotin-streptavidin complexClinical research
The invention discloses a kit detecting dog-hair allergen specific IgE antibody and a method. The kit comprises a calibration substance, a quality-control substance, a biotin-labeled dog-hair allergen solution, an alkaline-phosphatase-labeled mouse anti-human IgE secondary-antibody solution and a streptavidin-labeled nanometer-magnetic-particle suspension. The kit is utilized to detect the dog-hair allergen specific IgE antibody. Through the above manner, the reagent compositions in the kit are good in stability, the expiration data is one year or more, the detection sensitivity is high, the specificity is good, and variation is small. An improved unified technology is obtained after a large amount of experiments are performed for technology optimization, and production is performed strictly according to standard production operation rules and quality control rules. A user can perform standard operation and obtain a reliable result only according to the operation instruction. During clinic research, the coincidence correlation with a foreign imported reagent is up to 90% or more, and the cost only is 1 / 2 of the foreign imported reagent.
Owner:SUZHOU HAOOUBO BIOPHARML
Serum allergen specific IgE detection method based on micro-fluidic chip and protein chip
The invention belongs to the field of biomedicine, and relates to a serum allergen specific IgE detection method based on micro-fluidic chip and protein chip. Micro fluidic chip only need a trace amount of sample and is capable of quickly carrying out analysis; protein chip can perform high-flux analysis, and the provided method adopts the micro fluidic chip and protein chip and is developed on an antigen-antibody specific immunity response principle. The micro fluidic chip and protein chip are combined together to detect the allergen specific IgE in a clinical serum sample of an allergy sufferer. The results show that the provided method can effectively reduce the using amount of serum for detection. So the method is suitable for infants or children, who have little peripheral blood. Moreover, the using amount of detection reagents and detection time are both reduced. Compared with the prior art, the provided method has the characteristics of rapidness, high flux, reduced amount of serum, high efficiency, portability, and low cost. The method is especially suitable for analysis of large-scale epidemic disease.
Owner:FUDAN UNIV
Kit and method for detecting allergen-specific IgE antibody of cat hair
InactiveCN105445257AImprove stabilityStrong specificityChemiluminescene/bioluminescenceBiotin-streptavidin complexClinical study
The invention discloses a kit and a method for detecting the allergen-specific IgE antibody of cat hair. The kit comprises a calibration product, a quality control product, a biotin-labeled cat hair allergen solution, an alkaline phosphatase labeled mouse anti-human IgE secondary antibody solution and streptavidin labeled nano magnetic micro particle suspension; the kit is used for detecting the allergen-specific IgE antibody of cat hair. By the mode above, each reagent component in the kit is good in stability, and the period of validity can be more than or equal to one year; the detection flexibility is high, the specificity is good, and variation is tiny. A perfect uniform technology is obtained via the technological optimization of a great amount of experiments, and production is carried out according to the standardized production operation instructions and quality control instructions vigorously. A user can perform standard operation according to the operation specification so as to obtain the reliable result. In the clinical study, the conforming relevance to imported reagents abroad is higher than or equal to 90%, and the expense is only 1 / 2 that of the imported reagents abroad.
Owner:SUZHOU HAOOUBO BIOPHARML
Recombinant fusion alkaline phosphatase-allergen protein and preparation method and application thereof
ActiveCN108239651AHigh detection sensitivityReduce non-specific reactionsTransferrinsAntibody mimetics/scaffoldsNon specificityAntibody
The invention provides recombinant fusion alkaline phosphatase-allergen protein and a preparation method and application thereof, and comprises an expression vector of recombinant fusion alkaline phosphatase-allergen protein, a preparation method of the recombinant fusion alkaline phosphatase-allergen protein, the recombinant fusion alkaline phosphatase-allergen protein and application of the recombinant fusion alkaline phosphatase-allergen protein in in-vitro diagnosis of I type allergy. The invention also provides a kit and a detection method for detecting allergen-specific IgE antibody. Theprotein structure and physical and chemical properties of the recombinant fusion alkaline phosphatase-allergen protein are closer to natural allergen protein, and therefore, detection sensitivity ishigh and non-specificity is less; conventional mark inter-assay difference is avoided absolutely, and the production process of markers is simplified; the preparation process of key materials is simplified, production cost is lowered, the activity of allergen is improved, and kit use operation step and time are saved.
Owner:GUANGZHOU INST OF RESPIRATORY DISEASE +3
Kit detecting dermatophagoides-farinae allergen specific IgE antibody and method
InactiveCN105353133AImprove stabilityStrong specificityChemiluminescene/bioluminescenceBiological testingClinical researchSpecific antibody
The invention discloses a kit detecting dermatophagoides-farinae allergen specific IgE antibody and a method. The kit comprises a calibration substance, a quality-control substance, a biotin-labeled dermatophagoides-farinae allergen solution, an alkaline-phosphatase-labelled mouse anti-human IgE secondary-antibody solution and a streptavidin-labeled nanometer-magnetic-particle suspension. The kit is utilized to detect the dermatophagoides-farinae allergen specific IgE antibody. Through the above manner, the reagent compositions in the kit are good in stability, the expiration data is one year or more, the detection sensitivity is high, the specificity is good, and variation is small. An improved unified technology is obtained after a large amount of experiments are performed for technology optimization, and production is performed strictly according to standard production operation rules and quality control rules. A user can perform standard operation and obtain a reliable result only according to the operation instruction. During clinic research, the coincidence correlation with a foreign imported reagent is up to 90% or more, and the cost only is 1 / 2 of the foreign imported reagent.
Owner:SUZHOU HAOOUBO BIOPHARML
Detection of allergen-specific IgE
InactiveUS20050214866A1Low cost point-of-carePerformed simply and quicklyBioreactor/fermenter combinationsBiological substance pretreatmentsPoint of care deviceImmunotherapy
This invention relates to point-of-care devices and methods to screen animals with suspected IgE-mediated allergic disease. The present invention provides a simple and rapid preliminary immunoassay screen, in which a defined mixture of clinically relevant allergens is used to capture allergen-specific IgE present in a sample, followed by a second binding reagent that selectively binds IgE. The present invention further provides methods for prescribing immunotherapy treatment in animals having IgE-mediated diseases. Devices and kits useful for carrying out the methods of the invention are also provided.
Owner:MCCALL CATHERINE A +2
Peanut allergen specific IgE quantitative detection reagent, kit and application thereof
ActiveCN112180102APromote formationLarge specific surface areaBiological material analysisBiological testingHydrophilic polymersBiotin
The invention relates to the field of biological detection, in particular to a peanut allergen specific IgE quantitative detection reagent, a kit and application thereof. The kit is based on a magnetic particle chemiluminescence method, used allergens are subjected to biotinylation modification based on hydrophilic polymers, and the kit is high in sensitivity, good in specificity, short in reaction time and high in automation degree.
Owner:AUTOBIO DIAGNOSTICS CO LTD
Artemisia plant pollen allergen combination, application and kit
The invention discloses an artemisia plant pollen allergen combination for predicting an occurrence risk of asthma of an artemisia allergy patient, an application and a kit. The artemisia plant pollenallergen combination comprises Art v 1, Art ar 2, Art v 3 and Art an 7. The research on 240 artemisia pollen allergy cases discovers that when at least three kinds of allergen specific IgE in the Artv 1, the Art ar 2, the Art v 3 and the Art an 7 are positive in an artemisia pollen allergy case detection result, the occurrence rate of allergic asthma is 57%; when the positive number of the fourallergens is less than 3, the incidence rate of the allergic asthma is 24%; and the former is 2.4 times of the latter. By detecting the allergic patient, the patient with the high occurrence risk of the allergic asthma judged by detection can be possibly cured only by drug control and desensitization treatment, so that the occurrence of the allergic asthma is avoided.
Owner:杭州艾乐吉生物科技有限公司
Application of allergen specific IgE antibody idiotypic heterogeneity intensity in kit for allergen detection
PendingCN110763835AGood correlationIndividual particle analysisBiological testingDiseaseClinical manifestation
Owner:TIANJIN MEDICAL UNIV
A kind of rapid detection specific antibody IGE kit and preparation method thereof
The present invention relates to a rapid allergic disease allergen diagnosis kit through a two-step method, a preparation method and a use method thereof. During use of the kit, a serum sample requiring detection and catalase-labeled allergen are subjected to equal volume mixing, room temperature incubation is performed for 5-15 min, the mixed sample is added to a sample hole of colloidal gold test paper strip, and the result is read after 5-15 min, wherein the test strip comprises the sample hole, a colloidal gold pad, a film strip and a water suction pad, colloidal gold is conjugated with biotin labeled goat anti-catalase antibody through streptomycin protein and mouse anti-human IgE monoclonal antibody is coated on the film strip so as to form the colloidal gold-streptomycin protein-biotin-goat anti-catalase antibody-catalase-allergen-specific human IgE antibody-mouse anti-human IgE antibody complex, and the quality control zone is coated with mouse anti-goat IgG antibody. The total detection time of the kit is 10-30 min. The kit has characteristics of strong specificity, high sensitivity, simpleness, rapidness, on-site inspection and no requirement of professional training on operators, wherein operations on allergen specific IgE detection reagents can be completed according to the instruction.
Owner:北京新华联协和药业有限责任公司
Liquid phase chip for detecting allergen specific antibody and preparation method of liquid phase chip
ActiveCN103454412BComprehensive clinical testingAccurate clinical detection meansFluorescence/phosphorescenceBiotin-streptavidin complexFluorescence
Owner:NANJING BOMINDA BIO TECH
Test strip for ige screening of specific mushroom allergens and preparation method thereof
ActiveCN103995135BEasy to operateThe result is accurateDisease diagnosisBiological testingAntigenColloid
The invention provides a test strip for screening specific mushroom allergen IgE. The test strip is coated with a mushroom antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, colloidal gold is used for marking specific mushroom allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare the test strip product for allergen detection. The test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.
Owner:BIOSINO BIO TECH & SCI
Test strip for specific weed pollen allergen ige screening and preparation method thereof
ActiveCN103995131BSimple and fast operationThe result is accurateDisease diagnosisBiological testingAntigenPollen
Owner:BIOSINO BIO TECH & SCI
Allergen-specific IgE antibody quality control products and preparation method thereof
InactiveCN109142742AReduce in quantityLittle difference between bottlesBiological material analysisBiological testingQuality controlAntibody
The invention relates to allergen-specific IgE antibody control products. The allergen-specific IgE antibody control products comprise the quality control product L, the quality control product M andthe quality control product H; the quality control product L, the quality control product M and the quality control product H all include raw material components including a substrate and at least twoallergens, and the concentrations of the allergens in the quality control product L, quality control product M and quality control product H are different. The quality control products have many components, inspection requirements for common allergens of allergy can be met, and various allergens can also be added as needed, so that the detection range is wider, the batch difference can be effectively controlled, and therefore detection results are more accurate and reliable.
Owner:SUZHOU HAOOUBO BIOPHARML
Test strip for specific cereal allergen ige screening and preparation method thereof
ActiveCN103995132BSimple and fast operationThe result is accurateDisease diagnosisBiological testingAntigenColloid
The invention provides a test strip for screening specific cereal allergens IgE. The test strip is coated with a cereal antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, colloidal gold is used for marking specific cereal allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare the test strip product for allergen detection. The test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.
Owner:BIOSINO BIO TECH & SCI
Ige epitope-like peptides and uses thereof
PendingUS20210115097A1Avoid crosslinkingInhibition of secretionPeptide/protein ingredientsPharmaceutical delivery mechanismEffector cellIge epitope
The present invention relates to IgE epitope-like peptides which have ability to bind to allergen specific IgE paratopes. Said allergen specific IgEs are bound to effector cells of allergic patients. The IgE epitope-like peptides of the invention cover the paratopes of said IgE bound on effector cells, prevent biding of causative allergen on said IgE on effector cells, and thereby prevent degranulation and secretion of mediators of allergic inflammation from effector cells, after contact with the causative allergen. The present invention relates to the methods of using such IgE epitope-like peptides for therapy of allergic reaction. Said allergic reaction is caused by exposure to the causative allergen.
Owner:UNIVERSITY OF LJUBLJANA +1
Test strip for specific milk allergen ige screening and preparation method thereof
ActiveCN103983788BSimple and fast operationThe result is accurateDisease diagnosisBiological testingAntigenColloid
Owner:BIOSINO BIO TECH & SCI
Test strip for screening specific insulin allergen ige and preparation method thereof
The invention provides a test strip for screening specific insulin allergens IgE (Immunoglobulin E). The test strip is coated with an insulin antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, the colloidal gold mark is used for marking the specific insulin allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare a test strip product to carry out allergen detection; the test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.
Owner:BIOSINO BIO TECH & SCI
Test strip for specific animal dander allergen ige screening and preparation method thereof
ActiveCN103995112BSimple and fast operationThe result is accurateDisease diagnosisAntigenScreening method
Owner:BIOSINO BIO TECH & SCI
A method for detecting serum allergen-specific IGE based on microfluidic chip and protein chip
Owner:FUDAN UNIV
Test strip for specific silk allergen ige screening and preparation method thereof
ActiveCN103983790BSimple and fast operationThe result is accurateDisease diagnosisBiological testingColloidBiology
Owner:BIOSINO BIO TECH & SCI
Test strip for specific egg white allergen ige screening and preparation method thereof
ActiveCN103995133BSimple and fast operationThe result is accurateDisease diagnosisBiological testingAntigenColloid
Owner:BIOSINO BIO TECH & SCI
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