54 results about "Point of care device" patented technology

The smart medical compliance method and system invention prevents adverse drug events through the use of protocols that uniquely identifies the patient, care provider, medication and/or medical device that is to be used with radio frequency identification (RFID). The RFID devices incorporate fail-safe locks or indicators that prevent the inadvertent or unauthorized use of medication, medical devices, or medical supplies. The system corroborates, patient, the care provider, the medical device, and the manner in which it is to be used, and authorizes the action to be undertaken through an interface on a personal digital assistant PDA over a wireless communication channel. The system also timestamps events in the equivalent of a medical black box such that records may be kept to further improve patient care and allow an analysis of procedures. In addition, the system includes interfaces to medication preparation and safe disposal. A number of smart devices that interact with the system are also described. These include smart medical containers, smart clamps, smart valves, smart syringes, smart couplers, smart pipettes, and a host of other point of care devices.

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

A computer-implemented method to process POC information for potential QC compliance issues. A system and method for implementation of traditional laboratory analyzer based QC compliance in point-of-care (POC) environments is disclosed. A specific system and method to analyze data from POC testing to identify when the testing exceeds the variation expected under stable operation (i.e., the testing is “out of control”) is disclosed. This system and method is characterized by solving the QC compliance problem for POC devices by individuals not trained in traditional laboratory practices. This also provides the capability in real-time or near real-time to analyze POC testing information regarding the performance of each POC device, reagent kit (i.e., one kit per analyte tested) and/or lot, and operator so one can respond quickly to a particular device, reagent kit and/or lot, or operator that is not performing properly.

A plurality of Point-of-Care (POC) tests on a single cartridge (300) is provided such that sequential or nonsequential tests may be performed in an integrated fashion without changing the test cartridge. Each cartridge can contain a penetrating member sensor (302) combination in a radial disk format, interrogated and read by a single illumination/detection device. Alternatively a series of tests can be measured electrochemically and reported. Only those tests, which are required at the time, the sample is taken need to be reported, though all tests are carried out.

An ultrasonic field-portable system for accurately measuring hematocrit (HCT) and hemoglobin concentration (HGB) in small food samples. The system includes an analyzer (10) that allows extremely accurate measurements of blood hematocrit from only one or two drops of +>>d collected in a disposable sampling device (12) that is then inserted into the analyzer (10). The system is compact enough to package into a point of care device, making it a point of care device with accuracy comparable to larger CBC lab equipment.

Methods and devices for determining sensing device usability, e.g., for self-monitoring and point of care devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a humidity-responsive polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the humidity-responsive polymer layer; and determining whether the measured electrical property associated with the humidity-responsive polymer layer has exceeded a humidity threshold level associated with the device usability.

The invention provides for a novel dynamically configurable point-of-care device for clinical diagnostics and research for analysis of activity associated with pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, cardiovascular diseases, liver cell therapy, cell-cell signaling, epidemic outbreaks, hospital based infectious diseases, pathogens, germ cells, pharmacological compounds, oxidation reduction, microscopy, tomography, flow cytometry, clinical lab testing, and for providing immunoassays, ELISA, electrophoresis, PCR, chromatography, and other laboratory functions. The device comprises a biochemical processing module further comprising a processor and at least one controller, receiving microfluidic elements, sensors, software scripts, an electrically operated interface, flow ports, a user interface, memory, and a communications link, configurable based on analysis of patient data. The invention further provides for multiple-criteria decision analysis for hospital administrators, a wearable device, mobile medical device, molecular electronics configuration, touchscreen recognition, data analytics application, and a drone delivery based point-of-care system.

The present invention details a nanostructured electrochemical biosensor based on aptamer as the molecular recognition probe. The biosensor is comprised of an electrochemical cell that can be plugged into an electric controller. This electrochemical biosensor contains a working electrode made of the micro-/nano-scale gold dot array pattern, on which aptamer is immobilized on the surface of the dot array as the molecular recognition probe. The aptamer is labeled with an electrochemical indicator. Reversible binding of an analyte to the aptamer causes the change in the conformation of aptamer, consequently brings the electrochemical indicator close to the electrode surface. This results in the electron transfer from the electrochemical indicator to the electrode, which can be read as a change in output current or potential. The invented biosensor is a portable point-of-care device that has higher sensitivity, allows the measurement of the analyte more rapidly and requires much less sample volume than is presently available with current methods of detection.

A fully integrated and disposable point-of-care device for detecting a target nucleic acid is provided. The device comprises: an extraction chamber adapted to receive a biological sample, wherein said extraction chamber comprises means to extract and lyse the sample to release nucleic acid; a first amplification chamber in communication with the extraction chamber, wherein said amplification chamber comprises means to trigger nucleic acid amplification of a target nucleic acid sequence to occur; and a detection chamber in communication with the amplification chamber, wherein said detection chamber comprises means to detectably label the target nucleic acid and means to detect a signal associated with labeled target nucleic acid, or a single chamber for amplification, detection and identification of multiple nucleic acid sequences.

A diagnostic test for hepatocellular carcinoma is based on increases in the concentration of two biochemical markers in a biological sample, alpha-1-acid glycoprotein (AAG) or isoforms thereof and alpha-fetoprotein (AFP) or glycoforms thereof. Levels of these markers may be performed using an immunoassay. Also disclosed is a diagnostic kit for use in these assays that comprises reagents for detecting and/or measuring in AAG and AFP in blood, serum or tissue samples. A point-of-care device for the performance of such measurements is also disclosed.

This invention relates to point-of-care devices and methods to screen animals with suspected IgE-mediated allergic disease. The present invention provides a simple and rapid preliminary immunoassay screen, in which a defined mixture of clinically relevant allergens is used to capture allergen-specific IgE present in a sample, followed by a second binding reagent that selectively binds IgE. The present invention further provides methods for prescribing immunotherapy treatment in animals having IgE-mediated diseases. Devices and kits useful for carrying out the methods of the invention are also provided.

The present disclosure provides, in part, a self-contained, point-of-care device for the early detection of infection, or other pathologic conditions that can lead to system inflammation, by the detection of the endogenous gaseous mediator nitric oxide (NO.) and methods of use.

A method, system, test strip, point-of-care device and computer-implemented method for detecting a level of inflammation in a subject is provided. The level of inflammation is detected by contacting a biological sample obtained from the subject with a serum amyloid A (SAA) capture agent. The capture agent is secured to a substrate and is configured to emit a signal upon binding to SAA. The signal is detected and a result indicating the level of inflammation in the subject is output.

Compositions including a plurality of reactive components. The reactive components each include an inorganic core with one or more photoresponsive ligand(s) covalently bonded to a surface of the inorganic core. A composition may also include a photoinitiator. Methods of making an article of manufacture includes photochemically reacting at least a portion of one or more layer(s) formed from one or more composition(s). The photochemical reaction may be carried using a laser as a source of electromagnetic radiation. An article of manufacture, which may be a three-dimensional article of manufacture, may be or is a part of a microfluidic device, HPLC column, fluidic channel, point of care device, or diagnostics device.