The invention relates to the technical field of
organic synthesis, in particular to a method for synthesizing 4-
alkylresorcinol through a
solvent-
free system. The method comprises the following stepsthat (1)
resorcinol,
zinc chloride and
alkyl acid are evenly mixed, heated and stirred for a reaction, after cooling, water is added to precipitate a
solid, filtering,
drying and recrystallization areconducted, and thus 4-acylresorcinol is obtained; (2) the 4-acylresorcinol is dissolved into
trifluoroacetic acid, triethyl silicane is added dropwise, heating and stirring are conducted for a reaction, cooling and standing are conducted for layering, an
organic layer is extracted and dried,
filtration and concentration are conducted to obtain a crude product, recrystallization is conducted, andthe 4-
alkylresorcinol is obtained. According to the method, a triethyl silicane /
trifluoroacetic acid system is applied to synthesis of the 4-
alkylresorcinol for the first time, the reaction conditionis gentler and easier to control, and a post-treatment method is simple; and the
system does not contain a
solvent, water materials generated during industrial amplification are also greatly reduced,and thus the whole process is more environment friendly.