38 results about "3-methylbutyric acid" patented technology

The flavor and aroma characteristics of the smoke of a tobacco blend incorporating Oriental tobacco are improved by subjecting that blend to heat treatment. Oriental tobacco having a relatively high sucrose ester content is combined with a second dissimilar Oriental tobacco material and / or a non-Oriental tobacco material to form a tobacco mixture, and that mixture is heated for a time and under conditions sufficient to reduce the concentration of sucrose esters in the Oriental tobacco. Tobacco blends having reduced levels of sucrose esters yield smoke that does not possess undesirable off-notes provided by pyrolysis products of those sucrose esters; namely, 2-methylpropionic acid, 3-methylbutyric acid and 3-methylpentanoic acid.

A method for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in commercially viable amounts is disclosed. The reaction mixture cycles through an external heat exchanger while the primary reactant is added in a warmer so as to control and maintain a low temperature for the reaction mixture. The manufacturing process herein disclosed increases yield while decreasing reaction time from the synthetic processes currently practiced.

Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine.

The invention relates to an antisludging agent for preventing the deposition of Sr / Ba scale and the antisludging agent is used to prevent the deposition of Sr / Ba scale of an oil well during oil field production process. The antisludging agent comprises the following components by weight percent: 8.5-12% of dodecylaminoethyl phosphate, 7.5-9.0% of myristylaminoethyl phosphate, 5-6.5% of EDTA disodium salt, 2.5-3.0% of EDTP tetrasodium salt, 3.5-4.5% of ethylenediamine tetra methylenephosphonic acid, 0.05-0.08% of vitamin A, 0.05-0.12% of vitamin C, 0.005-0.01% of potassium iodide, 0.0005-0.001% of alpha-amino-3-methylbutyric acid, 0.0005-0.0010% of aspartic acid and the balance water, wherein the sum of the weight percentages of the components is 100%. The beneficial effect of the antisludging agent is as follows: when 25-30mg / l of the antisludging agent of the invention is used in the daily maintenance of the oil well, the scale preventing rate is more than 90% and the pump detection period of the oil well can be increased by more than once.

The invention discloses a solvent-free waterborne polyurethane resin and a preparation method thereof. The solvent-free waterborne polyurethane resin comprises the following raw materials in parts byweight: 80-150 parts of polyester or polyether glycol, 1-25 parts of 2,2-dihydroxymethyl isovaleric acid (2,2-dihydroxymethyl-3-methyl butyrate), 0-10 parts of hydrophilic carboxyl dihydric alcohol, 0-15 parts of micromolecule dihydric alcohol, 0-10 parts of nonionic dihydric alcohol, 40-150 parts of diisocyanate, 1-20 parts of a salting agent, 0-30 parts of a diamine chain extender and 500-700 parts of deionized water. The resin is free of organic solvent in the preparation process, low in prepolymer viscosity and high in dispersion stability.

A method for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in commercially viable amounts is disclosed. The reaction mixture cycles through an external heat exchanger while the primary reactant is added in a warmer so as to control and maintain a low temperature for the reaction mixture. The manufacturing process herein disclosed increases yield while decreasing reaction time from the synthetic processes currently practiced.

The invention discloses amidase, a coding gene and applications thereof. The amino acid sequence of the amidase is represented by the SEQ ID No.2. The amidase gene is cloned from acid-producing Klebsiella oxytoca KCTC 1686 genome. After the expression of the amidase gene, amidase can be successfully obtained, and the amidase has the advantages of high catalytic activity, good stereo-selectivity, high expression amount, and wind substrate spectrum. The obtained amidase can be used to prepare optically-pure chiral compounds especially an important medicine intermediate 2-(4-chlorophenyl)-3-methylbutyric acid. The recombinant amidase can be used to catalyze a racemic substrate 2-(4-chlorophenyl)-3-methylbutyramide, and when the substrate conversion rate is near 50%, the optical purity of the (S)-2-(4-chlorophenyl)-3-methylbutyric acid is 98.5%.

The invention discloses an acylation reaction method for preparing 2-4-(chlorophenyl)-3-methylbutyryl chloride. The acylation reaction method comprises the following steps: adding 900-950 parts by weight of 2-4-(chlorophenyl)-3-methylbutyric acid, 10-12 parts by weight of acetic acid and 20-25 parts by weight of activated carbon into a reaction kettle, dripping 510-520 parts by weight of thionyl chloride into the reaction kettle at normal temperature, performing heat release reaction, increasing the temperature to 80 DEG C, then opening the reaction kettle, stirring, performing heat preservation for 6hours after the end of dripping of the thionyl chloride, and press-filtering out the activated carbon and other impurities to obtain a crude product 2-4-(chlorophenyl)-3-methylbutyryl chloride. According to the acylation reaction method, the activated carbon is adopted for heat absorption, so that the smooth reaction conditions can be ensured, the yield is greatly improved, the acetic acid is increased and the stable reaction conditions are ensured so as to be conductive to performing the reaction.

The invention discloses an active component for inducing german cockroach. The active component comprises the following constituents in parts by weight: 0.1 to 5 parts of acetic acid, 0.1 to 1 part of isobutyric acid, 0.1 to 1 part of propionic acid, 0.1 to 5 parts of butyric acid, 0.1 to 10 parts of 3-methylbutanoic acid, 0.1 to 10 parts of n-pentanoic acid, 0.1 to 10 parts of n-hexylic acid, 0.1 to 10 parts of 4-methylpentanoic acid, 0.1 to 10 parts of sorbic acid, 0.1 to 10 parts of L-sorbic acid, 0.1 to 10 parts of gamma-decalactone, 0.1 to 10 parts of delta-decalactone, and 0.1 to 5 parts of 3-methylbutanoic acid-beta-benzoquinone ethyl ester. The active component has the inducing effect on both german cockroach imago and larvas of all ages, and specifically has the inducing effect on adult female, therefore, the inducing range is greatly expanded, and good inducing effect is achieved.

The invention discloses a synthesis process of compound D-2- aminoxy-3-methylbutyric acid, and belongs to the technical field of chemical synthesis. The synthesis process includes taking natural amino acid L-valine as a raw material, and then synthetizing the non-natural D-2- aminoxy-3-methylbutyric acid by steps of diazotization hydrolysis, acetyl protection, tert-butyl esterification, deacetylation, Mitsunobu reaction, dephthaloyl, tert-butyl ester hydrolysis and the like. The compound is synthetized by raw materials easy to obtain and is low-price; synthesis operations are convenient and simple, reaction conditions are mild and easy to control, reaction selectivity is good, yield is high, and accordingly the compound is suitable for industrial production.

The invention discloses high-strength temperature resistant viscoelastic fracturing fluid copolymer which is characterized by comprising the following components in mass percent, 5 to 20 percent of acrylic acid, 10 to 30 percent of acrylic amide, 2 to 15 percent of 2-acrylamide-2-methyl-1-propane sulfonate, 1 to 10 percent of 3-acryloyl imidogen-3-methylbutyric acid, 0.1 to 2 percent of lauryl mercaptan, and the balance of deionized water. The copolymer does not have water-insoluble residue, and has good sand-carrying effect and high-temperature resistance and shearing resistance, the viscosity of the copolymer with the mass fraction being 0.45 percent is kept more than 70 percent after continuous shearing for 1 hour at 170S-1 and below 120 DEG C. Raw material of the copolymer adopts industrial products, and is not required to be purified before reaction. Organic solvent is not used, the copolymer does not pollute the environment, the product yield is high, the reaction process is simple, the operation is easy, and the price is low.

Disclosed is a novel flavor-improving agent. Specifically disclosed is a flavor-improving agent which contains 3-methylbutanoic acid as an active ingredient.

Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine.

A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus brevicomis).

The present invention is related to a pork-flavor enhancer for food and soups, and contains 3-methylbutyric acid as an active ingredient.

The invention relates to an antisludging agent for preventing the deposition of Sr / Ba scale and the antisludging agent is used to prevent the deposition of Sr / Ba scale of an oil well during oil field production process. The antisludging agent comprises the following components by weight percent: 8.5-12% of dodecylaminoethyl phosphate, 7.5-9.0% of myristylaminoethyl phosphate, 5-6.5% of EDTA disodium salt, 2.5-3.0% of EDTP tetrasodium salt, 3.5-4.5% of ethylenediamine tetra methylenephosphonic acid, 0.05-0.08% of vitamin A, 0.05-0.12% of vitamin C, 0.005-0.01% of potassium iodide, 0.0005-0.001% of alpha-amino-3-methylbutyric acid, 0.0005-0.0010% of aspartic acid and the balance water, wherein the sum of the weight percentages of the components is 100%. The beneficial effect of the antisludging agent is as follows: when 25-30mg / l of the antisludging agent of the invention is used in the daily maintenance of the oil well, the scale preventing rate is more than 90% and the pump detection period of the oil well can be increased by more than once.

An oil modifier is prepared from 20-50% of 3-methylbutyric acid, 20-30% of streptomyces fradiae, 5-15% of fatty acid, 10-15% of amino acid and the balance inevitable impurities. The oil modifier has the advantage of being good in use effect.

Disclosed is a novel flavor-improving agent. Specifically disclosed is a flavor-improving agent which contains 3-methylbutanoic acid as an active ingredient.

The invention discloses one aspect, a high temperature resistant coating, comprising the following components in parts by weight: 20-30 parts of methyl 2-hydroxy-3-methyl butyrate, 12-16 parts of polyvinyl alcohol, polyamideimide 8-12 parts of amine, 6-8 parts of polyetherimide, 4-8 parts of polyimide, 7-15 parts of dibutyl ester, 6-12 parts of pentaerythritol, 12-24 parts of norfloxacin, dihydroacetate 6-12 parts of pine oil ester, 6-12 parts of dihydroterpineol, 4-12 parts of ethylene glycol monohexyl ether, 6-10 parts of dimethylethanolamine, 14-18 parts of cobalt calcium carbonate. The invention provides a kind of high temperature resistant coating, various components cooperate with each other, the coating has low toxicity, and the coating effect is good, and the service time is long. , can play the role of anti-corrosion and high temperature resistance.

The invention relates to a preparation method of MOC (methoxycarbonyl group)-L-tertiary leucine, in particular to a method for preparing the MOC-L-tertiary leucine by separating 2-methoxyamide-3, 3-methylbutanoic acid. The method comprises the following steps of forming two kinds of diastereoisomer amine salts by using the 2-methoxyamide-3, 3-methylbutanoic acid and a resolving agent which is an amine compound; separating the two kinds of diastereoisomer amine salts to obtain MOC-L- tertiary leucine amine salt; and performing acid dissociation on the MOC-L- tertiary leucine amine salt to obtain the MOC-L-tertiary leucine. The method is low in cost, a technology is simple and reasonable, the purity of products is high, and the method is suitable for industrial production of the MOC-L-tertiary leucine.

The invention discloses an active component for inducing german cockroach. The active component comprises the following constituents in parts by weight: 0.1 to 5 parts of acetic acid, 0.1 to 1 part of isobutyric acid, 0.1 to 1 part of propionic acid, 0.1 to 5 parts of butyric acid, 0.1 to 10 parts of 3-methylbutanoic acid, 0.1 to 10 parts of n-pentanoic acid, 0.1 to 10 parts of n-hexylic acid, 0.1 to 10 parts of 4-methylpentanoic acid, 0.1 to 10 parts of sorbic acid, 0.1 to 10 parts of L-sorbic acid, 0.1 to 10 parts of gamma-decalactone, 0.1 to 10 parts of delta-decalactone, and 0.1 to 5 parts of 3-methylbutanoic acid-beta-benzoquinone ethyl ester. The active component has the inducing effect on both german cockroach imago and larvas of all ages, and specifically has the inducing effect on adult female, therefore, the inducing range is greatly expanded, and good inducing effect is achieved.

A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus brevicomis).

The invention discloses a preparation method of 3,3-dimethyl butanol. According to the preparation method, in ethanol, 3,3-methylbutanoic acid is subjected to esterification under acid catalysis; and one-pot reaction is adopted in the presence of a hydroboron so as to obtain end product 3,3-dimethyl butanol. Using of flammable and combustible reagents (such as lithium aluminium hydride) and solvents (such as ether) is avoided; the end product is obtained via one-pot reaction; yield is high; purity is high; the raw materials are cheap, and source is wide; end product cost is low; and the preparation method is suitable for industrialized production.

The invention discloses amidase, a coding gene and applications thereof. The amino acid sequence of the amidase is represented by the SEQ ID No.2. The amidase gene is cloned from acid-producing Klebsiella oxytoca KCTC 1686 genome. After the expression of the amidase gene, amidase can be successfully obtained, and the amidase has the advantages of high catalytic activity, good stereo-selectivity, high expression amount, and wind substrate spectrum. The obtained amidase can be used to prepare optically-pure chiral compounds especially an important medicine intermediate 2-(4-chlorophenyl)-3-methylbutyric acid. The recombinant amidase can be used to catalyze a racemic substrate 2-(4-chlorophenyl)-3-methylbutyramide, and when the substrate conversion rate is near 50%, the optical purity of the (S)-2-(4-chlorophenyl)-3-methylbutyric acid is 98.5%.

The invention discloses green and non-toxic paint. The green and non-toxic paint comprises, by weight, 20 parts of 2-hydroxyl-3-methylbutyric acid methyl ester, 12 parts of polyvinyl alcohol, 12 partsof difluoro tetrachloroethane, 5 parts of chloroprene adhesive, 4 parts of sodium hydroxide, 12 parts of methyl celluloses, 12 parts of antimony trioxide, 4 parts of vanadium trioxide, 10 parts of azodicarbonamide, 12 parts of benzoyl peroxide, 8 parts of isopropyl alcohol, 4 parts of isopropyl acrylate and 8 parts of butyl acetate. The green and non-toxic paint has the advantages that various components in the green and non-toxic paint are matched with one another, and the green and non-toxic paint is low in toxicity; good paint smearing effects can be realized, and the green and non-toxic paint is long in service time.

The invention discloses an amino acid Schiff base coordination compound (S)-prolyl-2-aminobenzophenone-(S)-2-amino-2, 3-methylbutanoic acid Schiff base nickel, and a preparation method. The preparation method is characterized in that second halogenoalkane participates in the reaction to form the amino acid Schiff base coordination compound. The method prepares the target amino acid Schiff base coordination compound through the reaction of chiral auxiliary alanine Schiff base coordination compound (S)-prolyl-2-aminobenzophenone-(S)-amino acid Schiff base coordination compound and second halogenoalkane isopropyl nickel. The invention widens the application range of chiral auxiliary alanine Schiff base coordination compound (S)-prolyl-2-aminobenzophenone-(S)-amino acid Schiff base nickel, so through the method, more types of non-natural chiral amino acid can be synthetized.

The invention relates to a pork improver, which comprises: 10-20% of glucose oxidase, 50-60% of 3-methylbutanoic acid, 10-15% of fatty acid, 1-3% of sodium chloride, and the balance unavoidable impurities. The pork improver provided by the invention has good use effect.

The invention relates to the field of sterilization and disinfection, and particularly relates to low corrosive oxidation potential sterilization water and a preparation method thereof. The preparation method of the low corrosive oxidation potential sterilization water comprises the following steps: (1) providing an available chlorine provision unit which contains available chlorine or can generate available chlorine; (2) providing a pH value regulation unit; and (3) mixing the pH value regulation unit and the available chlorine provision unit to obtain a strong oxidizing solution, wherein the pH value of the strong oxidizing solution is 2-8, the oxidation-reduction potential is not lower than 600 mV, the available chlorine content is not lower than 3 mg / L, and the sum of the 3-methylbutyric acid content and the 3-methylbutyrate ion content is not higher than 1.8 mol / L. Compared with the existing acidic oxidation potential sterilization water, the sterilization water prepared by the oxidation potential sterilization water preparation method can reduce the corrosion to metal, thereby widening the application range.