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41results about How to "Weak side effects" patented technology
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Industrial synthesis method of polyarylether sulfone resin
The invention discloses an industrial synthesis method of polyarylether sulfone resin, which comprises the following steps: with 4,4'-dichlorodiphenyl sulfone and 4,4'-biphenol or 4,4'-dihydroxy diphenyl sulfone as reaction monomers, sulfolane as a solvent and sodium carbonate as a salt forming agent, adding the solvent into a reaction kettle filled with nitrogen protection, stirring and heating to 60-80 DEG C, and sequentially adding the reaction monomers, wherein the solid content of the system is 20-45%; after all monomers are dissolved, adding the salt forming agent into the system, then adding a dehydrating agent, stirring and heating to 200-210 DEG C, and performing a salt forming reaction for 1-2 hours; after the salt forming reaction is over, heating to 220-240 DEG C, and performing a constant-temperature polymerization reaction for 1-2.5 hours to obtain polymer mucus; cooling the polymer mucus with water, and grinding into powder; filtering, boiling with deionized water, washing to remove the solvent and the byproduct salt, and drying to obtain the polyarylether sulfone resin. The method disclosed by the invention can greatly shorten the reaction time, increase the productivity, reduce the consumption of raw materials, save the cost and reduce the energy consumption.
Owner:JIANGMEN YOUJU NEW MATERIALS
Coronary artery medicinal-coating stent
InactiveCN1935274AIncrease cAMP contentInhibit biosynthesisStentsSurgeryPhosphorylcholinePercent Diameter Stenosis
The present invention discloses a coronary artery medicine coating scaffold for inhibiting endometrial hyperplasia and preventing restenosis in the scaffold. It includes dilating scaffold base body and inner coating layer coated on the dilating scaffold base body, the above-mentioned inner coating layer is formed from medicine carrier and ligustrazine, their mass ratio is 3:1-1:3, the above-mentioned inner coating layer is one of methyl acrylate, methyl methacrylate copolymer, polylactic acid, polyglycollic acid, polymonoracemic lactic acid, polylactide-diglycolide polymer, phosphorylcholine, ethyl polyurethane inorganic micropore aluminium oxide and cellulose or their composite.
Owner:SOUTHEAST UNIV
High-fluidity polyphenylene ether sulfone ketone resin and industrial synthesis method thereof
The invention discloses a high-fluidity polyphenylene ether sulfone ketone (PPSUK) resin which is implemented through introducing an aromatic ketone monomer, especially a heterogeneous aromatic ketone monomer copolymer, into a PPSU polymer, so that the main chain of an obtained copolymer molecule contains a polyether sulphone and polyaryletherketone random copolymer structure, wherein the molar ratio of groups is (5-9):1. The machine-shaping temperature of a polymer prepared by using the method disclosed by the invention is usually not higher than 350 DEG C, and the polymer is high in fluidity and easy to machine, and has excellent solvent resistance, thereby expanding the product application field.
Owner:JIANGMEN YOUJU NEW MATERIALS
High-liquidity poly(ether sulfone ketone) (PESK) resin and industrial production process thereof
The invention discloses high-liquidity poly(ether sulfone ketone) (PESK) resin. Aromatic ketone monomers are introduced into a poly(ether sulfone) (PES) polymer, and particularly heterogeneous aromatic ketone monomers are copolymerized; and the main chain of the obtained polymer molecule contains an irregular copolymer structure of polyarylether sulfone and polyaryletherketone, wherein the molar ratio of the groups is (5-9):1. An industrial production process of the high-liquidity PESK resin consists of a salifying stage and a polymerization stage, wherein the solid content of the system in the salifying stage is 20-25%; and the solid content in the polymerization stage is 35-45%. By adopting the process provided by the invention, the processing forming temperature of the obtained polymer is generally not higher than 350 DEG C, the polymer has relatively high liquidity and is easy to process; and moreover, the solvent resistance is excellent, and the application fields of the product are widened.
Owner:JIANGMEN YOUJU NEW MATERIALS
General flavone of root of lilac daphne, method of extraction, and application
InactiveCN1915335AIncrease contentLow toxicityOrganic active ingredientsImmunological disordersChloroform methanolAlcohol
A general flavone of lilac daphne root is prepared from lilac daphne root through breaking, proportionally mixing it with alcohol, extracting at 40-70 deg.C for 12-48 hr, removing deposit, adsorbing by macroreticular resin, water washing, eluting with alcohol, vacuum distilling, passing through silicon gel column, eluting with the mixture of chloroform and methanol, and concentrating. It can be used to prepare the medicines for preventing and treating the sexual tumor.
Owner:XUZHOU NORMAL UNIVERSITY
Fiber-reinforced type polyether sulphone alloy blended and modified resin and preparation method thereof
The invention discloses fiber-reinforced type polyether sulphone alloy blended and modified resin and a preparation method thereof. The preparation method comprises the steps of mixing 20-75% of chain-extending polyether sulphone resin (PPSU, PES), 5-45% of polysulfone resin PSU, 10-40% of fibers, 0.1-5% of carbon black or titanium dioxide or a mixture of carbon black and titanium dioxide and 0.1-10% of various auxiliary agents, conducting extrusion, and obtaining the fiber-reinforced type polyether sulphone alloy blended and modified resin. The novel chain-extending polyether sulphone resin synthesized through the method is higher in mechanical strength, lower in melt viscosity and easier to process and form, an alloy material obtained by blending the fiber-modified-and-reinforced polyether sulphone resin and the polysulfone resin is good in flowability and heat resistance, mechanical properties of the reinforced alloy material such as tensile strength, bending strength and toughness are all substantially improved, and the application field of polyether sulphone series materials is expanded.
Owner:JIANGMEN YOUJU NEW MATERIALS +1
High-fluidity polyethersulfoneketone resin and industrial synthesis method thereof
The invention discloses a high-fluidity polyethersulfoneketone (PESK) resin. Aromatic ketone monomers (especially heterogeneous aromatic ketone monomers) are introduced into a PES polymer to carry out copolymerization reactions so as to obtain the high-fluidity polyethersulfoneketone resin, whose main chain comprises a random copolymerization structure composed of poly(aryl ether sulfone) and poly(aryl ether ketone), wherein the mole ratio of poly(aryl ether sulfone) group to poly(aryl ether ketone) group is in a range of (5 to 9):1. The processing temperature and molding temperature of the PESK resin is usually not higher than 350 DEG C; the PESK resin has a high fluidity, is easy to process, and has an excellent solvent-resistant performance; so the product application area is enlarged.
Owner:JIANGMEN YOUJU NEW MATERIALS
Composite agricultural drought-resistant water conservation agent
InactiveCN104694131AWeak side effectsLow costAgriculture tools and machinesOrganic fertilisersCellulosePotassium persulfate
The invention discloses a composite agricultural drought-resistant water conservation agent which is characterized by comprising the following components in parts by weight: 150-180 parts of carboxymethylcellulose, 6-10 parts of N,N-methylene bisacrylamide, 30-50 parts of humic acid, 700-1,000 parts of acrylamide, 60-80 parts of potassium persulfate, 200-375 parts of NaOH and 10,000-15,000 parts of distilled water. According to the composite agricultural drought-resistant water conservation agent disclosed by the invention, humic acid and carboxymethylcellulose are used as raw materials, and both are a natural material; particularly, humic acid is an important organic component of soil, and thus, the adverse reaction of soil caused by applying humic acid and carboxymethylcellulose is less than that caused by general synthetic substances; and meanwhile, since humic acid and cellulose are widely available and easy to get, the cost of the water conservation agent disclosed by the invention is lower than that of general water conservation agents, and the water conservation agent disclosed by the invention is more suitable for large-range popularization and application.
Owner:凯姆勒科技发展(天津)有限公司
A kind of high fluidity polyphenylene ether sulfone ketone resin and its industrial synthesis method
The invention discloses a high-fluidity polyphenylene ether sulfone ketone (PPSUK) resin which is implemented through introducing an aromatic ketone monomer, especially a heterogeneous aromatic ketone monomer copolymer, into a PPSU polymer, so that the main chain of an obtained copolymer molecule contains a polyether sulphone and polyaryletherketone random copolymer structure, wherein the molar ratio of groups is (5-9):1. The machine-shaping temperature of a polymer prepared by using the method disclosed by the invention is usually not higher than 350 DEG C, and the polymer is high in fluidity and easy to machine, and has excellent solvent resistance, thereby expanding the product application field.
Owner:JIANGMEN YOUJU NEW MATERIALS
Aqueous zinc ion battery positive electrode material, preparation method thereof and aqueous zinc ion battery
PendingCN112838198AIncrease capacityLess side effectsMaterial nanotechnologySecondary cellsElectrical batteryElectrode material
The invention discloses an aqueous zinc ion battery positive electrode material, a preparation method thereof and an aqueous zinc ion battery. The aqueous zinc ion battery positive electrode material comprises an inner core and a coating layer, wherein the inner core comprises MnO, the coating layer is formed on the outer surface of the inner core, and the coating layer comprises carbon. Therefore, the aqueous zinc ion positive electrode material is stable in structure and high in specific capacity, and an aqueous zinc ion battery prepared from the aqueous zinc ion positive electrode material is good in electrochemical performance, high in specific capacity and good in cycle performance.
Owner:REHAB ENERGY INC
Star type polysulfone resin industrial synthesis method
InactiveCN105330837AImprove performanceWide range of practical applicationsSynthesis methodsThermal stability
The invention discloses a star type polysulfone resin industrial synthesis method. Reinforced polysulfone resin is prepared through molecular design, excellent performance of original polysulfone is kept, melt viscosity of polysulfone is greatly reduced due to introduction of aromatic polyphenol, processing and forming are easier, thermal stability is higher, and the actual application field of polysulfone is greatly expanded. According to the method, the use amount of a key solvent of N-methyl pyrrolidone can be greatly reduced by controlling the solid content in the salifying stage and the polymerization stage and increasing the solid content in the polymerization stage, and cost is reduced.
Owner:GUANGDONG YOUJU ADVANCED MATERIAL RES CO LTD
Medicine for hyperlipemia and its production process
ActiveCN1985909AWeak side effectsSafe for clinical useMetabolism disorderCapsule deliveryDiseaseBlood circulation
The present invention relates to medicine, and is especially one kind of blood fat reducing Chinese medicine capsule prepared with red peony root, red sage, prepared fleeceflower root, and haw in the weight ratio of 1-1.5 to 1-1.5 to 1 to 1. The Chinese medicine capsule is used in preventing and treating hyperlipemia, atherosclerosis and other diseases. The Chinese medicine capsule possesses the functions of promoting blood circulation to disperse blood clots and reducing blood fat.
Owner:JUMPCAN PHARMA GRP
Retinoic acid and its analogs are used to treat tumors caused by tsc1/tsc2 inactivation or activation of its upstream pathway
InactiveCN102283826ALower doseLittle side effectsHydroxy compound active ingredientsDermatological disorderTumor therapyTSC2
The invention provides the use of retinoic acid and its analogs in the preparation of medicines for treating mammals including human tumors caused by TSC1 / TSC2 inactivation or activation of its upstream pathway. The invention also provides retinoic acid and its analogs and mTOR Use of the pharmaceutical composition composed of pathway inhibitors in the preparation of medicines for treating tumors in mammals including humans caused by TSC1 / TSC2 inactivation or activation of upstream pathways. The invention provides a new approach for the treatment of tumors caused by TSC1 / TSC2 inactivation.
Owner:THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Synthesis method of high-transparency polysulfone resin containing cycloalkyl group substituted phenol
The invention discloses a synthesis method of high-transparency polysulfone (PSU) resin containing cycloalkyl group substituted phenol. The method includes the steps of adding organic solvent in a nitrogen-protected reaction kettle with 4,4'-dichlorodiphenyi sulfone and bisphenol A as reaction monomers, wherein the mole ratio of 4,4'-dichlorodiphenyi sulfone to bisphenol A is 1 to 1; conducting stirring and temperature raising, sequentially adding the reaction monomers, adding a salt-forming agent and a water separation agent after all the monomers are dissolved, conducting stirring and temperature raising, and conducting the salt forming reaction for 1-2 hours; raising the temperature after the reaction ends, adding cycloalkyl group substituted phenol with the concentration of 0.1-5%, and conducting constant-temperature polymerization reaction for 4-5 hours to obtain polymerization mucus; cooling, smashing, washing and drying polymerization mucus to obtain the finished product. The method starts from the molecular structure level, cycloalkyl group substituted phenol is introduced into polymer molecular chains, the regularity of polymer chains is broken, the crystallization degree is lowered, and high-transparency polysulfone resin with ends capped by hydroxyl groups is prepared. The synthesized product keeps existing excellent performance of polysulfone, has the advantage of high light transmittance, and has better application prospects and great market value.
Owner:JIANGMEN YOUJU NEW MATERIALS
A kind of industrial synthesis method of poly(aryl ether ketone resin) with high thermal stability capping containing biphenyl structure
Owner:JIANGMEN YOUJU NEW MATERIALS
Fusion vesicle derived from bacteria and plants as well as preparation method and application of fusion vesicle
ActiveCN113425842AGood long cycle characteristicsGood tumor targetingPhotodynamic therapyPharmaceutical non-active ingredientsTumor targetTumor targeting
The invention provides a fusion vesicle derived from bacteria and plants as well as a preparation method and application of the fusion vesicle, and relates to the technical field of biomedicine. The fusion vesicle comprises a mixed membrane structure formed by fusing a bacterial outer membrane vesicle and a plant thylakoid membrane, wherein the bacteria are gram negative bacteria, and the plant thylakoid is a spinach thylakoid. The fusion vesicle of the present invention combines the characteristics of the bacterial outer membrane vesicle and the plant capsular membrane, the structure of the vesicle is uniform, the vesicle can efficiently and rapidly reach the tumor, the tumor targeting property is high, and the accumulation time is long; and the obvious effect is realized in the aspect of tumor treatment.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Application of spermidine in preparation of aortic aneurysm treatment drug
ActiveCN110548020AGood treatment effectClear toxicology and pharmacologyOrganic active ingredientsCardiovascular disorderSide effectTherapeutic effect
The invention discloses an application of spermidine in preparation of an aortic aneurysm treatment drug. The application has beneficial effects as follows: spermidine can be taken as a drug for delaying progression of abdominal aortic aneurysm, has a good treatment effect in animal experiments, and has clearer toxicology and pharmacology, higher safety and weak toxic and side effects.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Traditional Chinese medicine compound composition capable of treating infantile constipation as well as preparation method and application thereof
InactiveCN108159161AGood treatment effectImprove securityDigestive systemBird material medical ingredientsSide effectTherapeutic effect
The invention discloses a traditional Chinese medicine compound composition capable of treating infantile constipation and a preparation method thereof. The traditional Chinese medicine compound composition is prepared from 6-15 parts of immature bitter orange, 6-15 parts of magnolia officinalis, 6-15 parts of snakegourd root, 6-15 parts of fructus forsythiae, 6-15 parts of medicated leaven, 6-15parts of fried cassia seed, 3-5 parts of rhubarb, and 3-9 parts of chicken's gizzard-membrane. The traditional Chinese medicine compound composition provided by the invention provides treatment according to differentiation of symptoms and signs on the basis of the theory of traditional Chinese medicine and has a scientific prescription according to the pathogenesis of infantile constipation; and experimental research results prove that the traditional Chinese medicine compound composition provided by the invention has scientific and reasonable proportion of each component, can obviously improve the activity of pepsin in rats, has a promoting effect on a propulsion function of small intestines in mice, and can reduce serum SS of the mice, and increase MTL and GAS, thereby regulating gastrointestinal hormones and promoting gastrointestinal peristalsis. Moreover, clinical experimental results show that the traditional Chinese medicine compound composition has a very good therapeutic effect on infantile constipation, and has good safety and no toxic or side effects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
High fluidity polysulfone ketone resin and its production process
The invention discloses high-liquidity polysulfone ketone resin and a production process. An aromatic ketone monomer is introduced into a PSU polymer; especially a heterogeneous aromatic ketone monomer is copolymerized; the aromatic ketone monomer accounts for 10%-25% of total mole of an aromatic sulphone monomer; a main molecular chain of the prepared polysulfone ketone resin contains a polysulfone and polyaryletherketone random copolymer structure. The melting point of the prepared product is 305-340 DEG C; the processing and molding temperature is not higher than 350 DEG C in general; the melt index is 10.0-30 g / 10min; and the high-liquidity polysulfone ketone resin has the advantages of being relatively high in liquidity and easy to process, and can be widely applied to various thin-wall products.
Owner:JIANGMEN YOUJU NEW MATERIALS
A kind of high fluidity polyethersulfone ketone resin and its industrial synthesis method
The invention discloses a high-fluidity polyethersulfoneketone (PESK) resin. Aromatic ketone monomers (especially heterogeneous aromatic ketone monomers) are introduced into a PES polymer to carry out copolymerization reactions so as to obtain the high-fluidity polyethersulfoneketone resin, whose main chain comprises a random copolymerization structure composed of poly(aryl ether sulfone) and poly(aryl ether ketone), wherein the mole ratio of poly(aryl ether sulfone) group to poly(aryl ether ketone) group is in a range of (5 to 9):1. The processing temperature and molding temperature of the PESK resin is usually not higher than 350 DEG C; the PESK resin has a high fluidity, is easy to process, and has an excellent solvent-resistant performance; so the product application area is enlarged.
Owner:JIANGMEN YOUJU NEW MATERIALS
Application of spermidine in preparation of medicine for treating aortic aneurysm
ActiveCN110548020BGood treatment effectClear toxicology and pharmacologyOrganic active ingredientsCardiovascular disorderPharmaceutical drugTherapeutic effect
The invention discloses the application of spermidine in the preparation of medicine for treating aortic aneurysm. The beneficial effect of the present invention is that the spermidine can be used as a drug for delaying the progress of abdominal aortic aneurysm, and the drug has achieved good therapeutic effects in animal experiments, has relatively clear toxicology and pharmacology, high safety, and weak toxic and side effects.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
A kind of glass fiber reinforced chain extension modified polyaryl ether sulfone resin and preparation method thereof
The invention discloses glass fiber-enhanced chain-extending modified polyether sulphone resin and a preparation method therefor. The preparation method comprises the step of mixing and extruding the following: 50-90% of chain-extending polyether sulfone resin (PPSU, PES); 9-40% of fiber; 0.1-5% of carbon black or titanium dioxide; and 0.1-10% of various auxiliary agents. The synthetic process disclosed by the invention is simple and the production efficiency is high. The synthesized novel chain-extending modified polyether sulphone resin has higher mechanical strength and lower melt viscosity, and is more liable to be processed and moulded. Meanwhile, the fiber-modified and enhanced polyether sulphone resin is good in flowability and heat resistance, and the mechanical properties of the enhanced resin such as tensile strength, bending strength and toughness are improved to a great extent, so that the application field of the polyether sulphone material is widened.
Owner:JIANGMEN YOUJU NEW MATERIALS +1
A kind of industrial synthesis method of high thermal stability capped polyaryl ether sulfone resin
Owner:JIANGMEN YOUJU NEW MATERIALS
Nitrate NO donor type tripyridine bisoxazole compound as well as preparation method and application thereof
ActiveCN112300148AWeak side effectsHigh selectivityOrganic active ingredientsOrganic chemistryTheoretical and experimental justification for the Schrödinger equationNo donors
The invention discloses a nitrate NO donor type tripyridine bisoxazole compound as well as a preparation method and application thereof. The structural formula of the nitrate NO donor type tripyridinebisoxazole compound is shown as a formula (I) in the description, wherein in the formula (I), n is 1 or 2. The nitrate NO donor type tripyridine bisoxazole compound disclosed by the invention shows targeted combination with a G-quadruplex and basically does not generate a combination effect with double helix DNA, so that targeted release of NO in tumor cells is realized, NO and a flexible G-quadruplex ligand generate a synergistic anti-tumor effect, and only weak toxic and side effects are generated. Theoretical and experimental bases are provided for developing novel anti-tumor drugs with high selectivity, high efficiency and low toxic and side effects on the basis of double functions of targeting G-quadruplex and releasing NO.
Owner:ANHUI MEDICAL UNIV
Composition of main ingredients for treating carbuncle, burn and acne, sustained and controlled release pharmaceutical preparation, preparation method and application thereof
ActiveCN113713000BDispelling wind and relieving itchingWith detoxification and swellingHydroxy compound active ingredientsAerosol deliveryCentella asiatica extractDrugs preparations
The invention provides a main drug component composition, a slow-controlled-release pharmaceutical preparation, and a preparation method and application thereof for treating sore carbuncles, burns and scalds and acne. The main medicinal composition for treating carbuncle, burn and acne includes Kochia kohlrabi extract, Centella asiatica extract and borneol, based on the total weight of the composition, the Kochia kohlrabi extract The content of the extract is 40-75% by weight, the content of the Centella asiatica extract is 20-50% by weight, and the content of the borneol is 1-10% by weight. The main drug has the functions of expelling wind and relieving itching, detoxification and swelling, clearing heat and dispelling knots. It is non-irritating and has stable drug release. It can relieve inflammation and reduce scars caused by inflammatory reactions.
Owner:江苏集萃新型药物制剂技术研究所有限公司
Traditional Chinese medicine preparation for preventing and treating bacterial dysentery
InactiveCN110898199AEasy to killThe ratio is scientific and reasonableAntibacterial agentsDigestive systemBiotechnologySmoked Plum
The invention discloses a traditional Chinese medicine preparation for preventing and treating bacterial dysentery. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight of 20-80 parts of honeysuckle flowers, 10-60 parts of common andrographis herbs, 10-30 parts of smoked plums, 10-30 parts of wrinkled gianthyssop herbs, 10-30 parts of fresh ginger, and 10-60 parts of licorice roots. According to the traditional Chinese medicine preparation for preventing and treating bacterial dysentery provided by the invention, through massive test screening, the compounding ratio is scientific and reasonable. Experiment results indicate that the traditional Chinese medicine preparation has good efficacy of killing bacteria and preventing and treating bacterial dysentery, and is low in adverse reactions, weak in toxic and side effects and good in safety performance.
Owner:南京昕海医药科技有限公司
A kind of high strength polysulfone resin and preparation method thereof
ActiveCN105418924BLow high and low temperature alternating performanceLow dielectric propertiesPolymer scienceBoiling point
The invention discloses high-strength polysulfone resin and a preparation method thereof. The preparation method specifically comprises a salt forming reaction, a polymerization reaction and aftertreatment, wherein a chain extender containing Si, C or Ti is added in the polymerization reaction; and a high-boiling point solvent is adopted, sodium carbonate is preferentially adopted as a salt forming agent, and the solid content of the salt forming reaction and polymerization reaction is controlled. Through the invention, the production cost and energy consumption can be reduced, and the obtained polysulfone resin has good mechanical property, hydrophobic property, tensile strength, impact toughness, thermal stability and fluidity.
Owner:GUANGDONG YOUJU ADVANCED MATERIAL RES CO LTD
A method for synthesizing high-strength polyaryl ether sulfone resin by adding chain extender in the middle section
The invention discloses a method for synthesizing high-strength polyaryl ether sulfone resin by adding a chain extender in the middle section, comprising the steps of: using 4,4'-dichlorodiphenyl sulfone and 4,4'-biphenol or 4, 4′‑dihydroxydiphenyl sulfone is the reactive monomer. In the nitrogen-protected reaction kettle, after adding the solvent, start to stir and raise the temperature to 60°C-80°C. Add the reactive monomers in sequence. After dissolving, add the salt forming agent Then add the water separating agent, continue to stir and raise the temperature to 200°C-210°C, and react for 1-2 hours after salt formation; then raise the temperature to 220°C-240°C, perform constant temperature polymerization for 1-2 hours, then add the chain extender and continue the reaction After 40 minutes, the obtained high-strength polyaryl ether sulfone resin viscous is cooled, pulverized, filtered, and dried in a vacuum. The synthesis process of the invention is simple, the production efficiency is high, and the synthesized novel reinforced polyaryl ether sulfone resin has higher mechanical strength, lower melt viscosity, easier processing and molding, and higher thermal stability.
Owner:JIANGMEN YOUJU NEW MATERIALS +1
Method for increasing survival rate of tachypleustridentatus larvae by controlling concentration of trichlorfon
InactiveCN107509665AWeak side effectsReduce biological activityClimate change adaptationPisciculture and aquariaHigh survival rateZoology
The invention belongs to the technical field of tachypleustridentatus larva culture, and discloses a method for increasing the survival rate of tachypleustridentatus larvae by controlling the concentration of trichlorfon. The safety concentration of trichlorfon is 0.3813 g / L; the survival rate of tachypleustridentatus larvae is 100% by using trichlorfon with the concentration of 2.0 g / L or below; the LC50 of trichlorfon on tachypleustridentatus is 0, 7.88 g / L, 5.912 g / L, 5.912 g / L, 5.912 g / L, 4.143 g / L, 4.038 g / L and 3.813 g / L. at 12 h, 24 h, 36 h, 48 h, 60 h, 72 h, 84 h and 96 h respectively. According to the method, the safe concentration and intensity of trichlorfon for influencing the survival of tachypleustridentatus larvae in the first stage are obtained, and the survival rate of tachypleustridentatus larvae is increased.
Owner:QINZHOU UNIV
Short peptide targeting ikkβ and its application in inflammatory diseases
ActiveCN111978408BInhibit bindingInhibition formationPolypeptide with localisation/targeting motifPeptide/protein ingredientsSynthetic ImmunogensArthritis
The invention belongs to the field of biomedicine, in particular to a short peptide targeting IKKβ and its application in inflammatory diseases. In order to provide a more effective treatment for inhibiting inflammatory responses, the present application provides a short peptide targeting IKKβ, the short peptide includes the N-terminal amino acid 46-60 region derived from the IκB kinase binding protein IKIP, and the N-terminal of the short peptide is fused through Membrane peptides, with peptide tags. The short peptide can target IKKβ, inhibit the combination of IKKβ and IKKγ, thereby inhibiting the formation of IKK complex, reducing the expression of inflammatory cytokines TNF-α and IL-6, and inhibiting the inflammatory response. Animal models have shown that short peptides can effectively treat arthritis and inflammatory bowel disease. Compared with the full-length protein, the short peptide has a small molecular weight, is easy to synthesize, has weak immunogenicity, and has relatively weak side effects; it has better absorption with cell-penetrating peptides, and is easy to track and observe with peptide tags, which is a great tool for clinical treatment of inflammatory diseases for reference.
Owner:SHANDONG UNIV
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