The invention provides a waterproof anti-collision expanded connecting structure of handheld terminal equipment. The waterproof anti-collision expanded connecting structure comprises a host machine and a sub-machine, wherein mutually-adapted guide rail structures are arranged on the housings of the host machine and the sub-machine to be butted, and the inner parts of the guide rail structures are provided with connecting pieces which are used for circuit and communication connection of the host machine and the sub-machine. The host machine has basic functions of voice communication, satellite positioning, pickup, taking a picture, bluetooth and the like, and the sub-machine can be arbitrarily switched into expanded sub-machines with various functions as needed, such as printers, POS (Point-of-Sale) card readers, identity recognizers, fingerprint readers, bar code readers and the like. Meanwhile, according to various usages, the host machine can arbitrarily select different sub-machines to form handheld terminal equipment which is suitable for various fields of public security, electric power, banks, logistics, finance, railway and the like. The waterproof anti-collision expanded connecting structure has the characteristics of firm and stable combination, small size, one-hand operation, one machine for multiple purposes, convenience in carrying and the like.