The invention discloses a novel prefabricated frame structure. The novel prefabricated frame structure comprises vertical columns (1), main beams (2), secondary beams (3) and a floor (5); the main beams (2) and the secondary beams (3) adopt prefabricated members and are provided with reserved and exposed steel bars; the floor (5) is a laminated board, a prefabricated board (51) is adopted on the bottom of the floor, and concrete is cast in situ on the top parts of the prefabricated board (51), the main beams (2) and the secondary beams (3) to combine the prefabricated board (51), the main beams (2) and the secondary beams (3); reserved and exposed steel bars are arranged at the tops of the vertical columns (1), prefabricated columns of to-be-cast structures are arranged at the bottoms of the vertical columns, the to-be-cast structures are used for being connected to a lower layer building structure, exposed steel bars of the lower layer building structure is inserted inside the to-be-cast structures, and the connection between the vertical columns (1) and the lower layer building structure is realized by in-situ casting of concrete in the to-be-cast structures. According to the novel prefabricated frame structure, on-site construction working quantity can be effectively lowered, pollution and wasting are decreased, human resources are greatly lowered, construction efficiency iseffectively improved, and the construction period is shortened.