34results about How to "Reasonable synthetic route" patented technology

The present invention relates to polymerisable fluorescent functional monomers in the structure as shown, and they have strong fluorescent reaction and part capable of reacting with biomacromolecular protein and non-covalent bond of DNA mutually. They may be polymerized with hydrophilic monomer to obtain fluorescent amphiphilic polymer with excellent biocompatibility, medicine carrying capacity and target administration capacity, and the polymer may find wide application foreground in high sensitivity fluorescent tracing detection technology, biomacromolecule separation and distinction, biosensor, medical diagnosis, medicine conveying, target material and other aspects. The present invention has reasonable synthesis path, simple synthesis process, easy-to-obtain material and high application value.

The invention discloses a compound 2-substituent-5-substitued anilino-1,3,4-oxadiazole derivative with functions of resisting plant germs and plant viruses and a preparation method and an application thereof, wherein the structure of the compound is represented by the general formula (I). In the invention, the substituted arylamine is adopted as a start raw material, and a thioether compound is prepared by the steps of esterification, hydrazinolysis, salifying, ring closing and etherification; a sulfone compound is prepared by thioether oxidization. The compound disclosed by the invention has a good inhibiting effect on gibberella zeae, pepper fusarium wilt pathogen, valsa mali and tobacco mosaic virus and can be used for preparing medicines resisting plant germs and plant viruses.

The invention discloses a novel tobacco humectant 3-O carboxymethyl-D-glucose. The fork group protects and deprotects the hydroxyl group of D-glucose, and successfully synthesizes the new polyhydroxy tobacco humectant—3-O-carboxymethyl-D-glucose. Through the physical moisturizing performance test and the internal sensory quality evaluation, it was found that the humectant has a good physical moisturizing effect on cigarettes, and can reduce the irritation and miscellaneous gas of cigarettes, and improve the roundness and comfort of cigarette smoke.

The invention discloses a novel tobacco moisturizer 3-O-hydroxyethyl-D-glucose. The propylidene group protects and deprotects the hydroxyl group of D-glucose, and successfully synthesizes the novel polyhydroxy cigarette humectant 3-O-hydroxyethyl-D-glucose. Through the physical moisturizing performance test and the internal sensory quality evaluation, it was found that the humectant has a good physical moisturizing effect on cigarettes, and can reduce the irritation and miscellaneous gas of cigarettes, and improve the roundness and comfort of cigarette smoke.

The invention provides a novel weakly cross-linked particle control and displacement agent capable of enhancing oil recovery and a preparation method thereof. The drive control agent is formed by polymerization of acrylamide monomer and composite crosslinking system through an initiator. Its preparation method is: dissolve 100 parts of acrylamide in 200-250 parts of water to make a solution, dissolve 0.2-0.5 parts of dimethylaminoethyl methacrylate in 30-50 parts of water to make a solution, and dissolve 0.0002-0.001 parts of polyethylene Diol diacrylate is dissolved in 20~40 parts of water to form a solution, which is added to the three-necked bottle in turn, and placed in a water bath at 10°C~15°C; after 30 minutes of nitrogen gas, dissolve 0.01-0.03 parts of ammonium persulfate Add the solution prepared in 30~50 parts of water into the three-necked bottle. After the temperature rise of the reaction solution is greater than 1°C, stop the nitrogen flow. After the reaction, put the three-neck bottle into a water bath at 70-85°C to keep warm for 2-6 hours, then take out the gel, cut it into pieces, dry, pulverize, The powdered product can be obtained after sieving.

The invention relates to a constrained geometry carbon-bridged single metallocene compound, its preparation and application; a structural general formula is shown as the following: wherein R denotes H, or allyl or t-butyl containing 1 to 10 carbon atoms; R1,R2 denote H, Or alkyl, allyl, aromatic base or silicon-based containing 1 to 10 carbon atoms; M denotes Ti or Zr; Cp denotes cyclopentadienyl, substituted cyclopentadienyl, indenes or substituted indenes. The application of the constrained geometry carbon-bridged single metallocene compound is suitable for catalyzing ethane / 1- hexane, ethane / 1-octene copolymerization, reaction temperature is 70 DEG C, the reaction time is 0.5 hour, the aluminum / zirconium ratio is 1000, the concentration of 1-octene is 0.6 mol / L and ethene pressure is 0.1 MPa, polymerization activity is 2.76*106 g PE / mol.cat.h., the 1-octene content in polymer is 19.07%, catalytic activity is high during copolymerization, the insertion rate of the long chain alpha-alkene is high.

The present invention relates to polymerisable fluorescent functional monomers in the structure as shown, and they have strong fluorescent reaction and part capable of reacting with biomacromolecular protein and non-covalent bond of DNA mutually. They may be polymerized with hydrophilic monomer to obtain fluorescent amphiphilic polymer with excellent biocompatibility, medicine carrying capacity and target administration capacity, and the polymer may find wide application foreground in high sensitivity fluorescent tracing detection technology, biomacromolecule separation and distinction, biosensor, medical diagnosis, medicine conveying, target material and other aspects. The present invention has reasonable synthesis path, simple synthesis process, easy-to-obtain material and high application value.

The invention relates to a preparation method of tedizolid impurity, which comprises the steps of treating compound A with a strong base in the presence of oxygen, adding glycidyl ester, and reacting to obtain tedizolid impurity. The high-purity tedizolid impurity can be prepared by the method, and the method has high yield and simple operation, and the product can be used as a reference substance of the tedizolid impurity, and then the purity of the intermediate is monitored in the synthesis process of the tedizolid.

The invention provides a quatenary core end epoxy hyperbranched polyester and a preparation method thereof, relates to the technical field of composite materials and in particular relates to a toughening agent for fiber composite material matrix resin and a preparation method for the toughening agent. According to the invention, the problems that the hyperbranched polyester serving as the toughening agent of the epoxy resin matrix has single structure, low compatibility with epoxy resin, a complex synthesis process and the like are solved. The structural formula of the quatenary core end epoxy hyperbranched polyester is shown as the specifications. The preparation method comprises the following steps: I, mixing and stirring; II, preparing a hydroxyl-terminated hyperbranched polyester crude product; III, preparing hydroxyl-terminated hyperbranched polyester; IV, preparing an epoxidation solution; V, preparing alkaline liquid; VI, preparing a neutralization solution; and VII, washing and drying to obtain the quatenary core end epoxy hyperbranched polyester. The method is mainly used for preparing the quatenary core end epoxy hyperbranched polyester.

The invention provides a preparation method of 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxy-1-piperidyl) phenyl]-2(1H)-pyridine. The preparation method comprises the following steps: step (1) reducing N-(4-nitrobenzophenone)-3,3-dichloro-2-oxy piperidine (10) which is used as an initial raw material by utilizing a reducing agent to obtain a compound 13; step (2) acylating the compound 13 and 5-bromine valeryl chloride in the presence of catalyst and acid-binding agent to obtain a compound 14; step (3) facilitating the reaction of the compound 14 in the presence of cyclic condensation agent to obtain a compound 15; step (4) facilitating the reaction of the compound 15 and morpholine in the presence of alkali to obtain a compound 5, wherein the reaction route is as follows. Compared with the prior art, the preparation method has the advantages that the limitation of enamine structure on the synthesized pyridone ring can be avoided, the synthesis of the pyridone ring can be simplified, and the synthesizing route is more reasonable; fewer reaction side products are produced, easiness in purification is realized, the total yield is high, and simplicity in reaction operation is realized; the preparation method is very suitable for the industrialized production.

The present invention provides a branched viscoelastic powder oil displacement agent and its preparation method. The method is carried out as follows: a. Acrylamide aqueous solution is prepared according to the ratio of acrylamide: water = 100:200-250 parts by weight; b. First take the acrylamide aqueous solution in step a and put it into a three-neck container, and in a water bath at 10°C to 15°C, blow nitrogen gas for 15 to 30 minutes. The persulfide aqueous solution prepared according to the ratio and the polyhydroxy compound aqueous solution prepared according to the ratio of polyol: water = 0.0018 to 0.004: 40 to 60 parts by weight are added to a three-neck container for reaction, and after the temperature of the reaction solution exceeds 1 °C , stop the nitrogen flow, and start to record the temperature of the reaction system; c. When the temperature of the reaction system no longer rises, put the three-neck container in a water bath at 70-85°C and keep it warm for 4-6 hours, then take out the gel, dry it, Pulverize to obtain viscoelastic powder oil displacement agent products.

The invention discloses a flavor-enhancing moisturizer 1-L-tryptophan-1-deoxy-D-fructose for cigarettes. As a raw material, a flavor-enhancing humectant 1-L-tryptophan-1-deoxy-D-fructose for cigarettes was successfully synthesized through a simple reaction process. Through physical moisturizing performance tests and intrinsic sensory quality evaluations, it was found that The humectant has a good physical moisturizing effect on cigarettes, and can reduce the irritation and miscellaneous gas of cigarettes, and improve the roundness and comfort of cigarette smoke.

The invention provides a preparation method for (2R,3S)-1-chlorine-3-tert-butoxycarbonylamino-4-phenyl-2-butanol. The preparation method comprises the steps that L-phenylalanine is taken as raw materials, protected by adopting benzyl, esterified and then catalyzed through NMM to generate a mixed anhydride compound, the mixed anhydride compound reacts with diazomethane to generate diazoketone, a reduction reaction and palladium carbon reduction are performed, and finally the intermediate (2R,3S)-1-chlorine-3-tert-butoxycarbonylamino-4-phenyl-2-butanol is obtained. According to the preparation method, the low-cost benzyl is adopted to protect amidogen, the synthetic route is reasonable, the operation technology is simple, safe and high in yield, industrialization can be well achieved, and the production efficiency is improved.

The invention discloses a preparation method and biological activity of an amino acid ester compound containing a 4-(dimethoxymethyl)pyrimidine heterocycle, which is a compound for preventing and treating tobacco mosaic virus. It is composed of the following general formula ( I) the compound represented by it and the preparation method thereof. The present invention introduces the use of 4-(dimethoxymethyl)pyrimidin-2-amine, substituted aldehyde, and malonate as raw materials, toluene as solvent, and under ultrasonic conditions, a one-pot synthesis method containing 4-(dimethoxy) Amino acid esters of pyrimidine heterocycles. Compound I of the present invention 5 and I 8 It has good inhibitory effect on tobacco mosaic virus and tobacco bacterial wilt. (I).

The invention relates to a bis-silicon-bridged dinuclear metallocene compound and preparation and application thereof. The bridged cyclopentadienyl rings of the bis-silicon-bridged dinuclear metallocene compound contain different substituents. Dimethyldichlorosilane reacts with cyclopentadienyl sodium, so that light yellow solution is obtained; the light yellow solution reacts with n-butyl lithium, and dimethyldichlorosilane is then added for reaction, so that bis-silicon-bridged dicyclopentadiene is obtained; the bis-silicon-bridged dicyclopentadiene reacts with n-butyl lithium, halogenide is then added for reaction, n-butyl lithium is then added for reaction, and finally, another halogenide is added for reaction, so that ligand L is obtained; and cyclopentadienyl titanium trichloride orcyclopentadienyl zirconium trichloride or substituetd cyclopentadienyl titanium trichloride or substituetd cyclopentadienyl zirconium trichloride is added in the ligand L, so that the compound is obtained. The synthesis route is reasonable, the yield is high, separation and purification are easy, the amount of needed cocatalysts is less when the compound is used for catalyzing the copolymerization of ethylene, such as ethylene / hexene-1, ethylene / octene-1 and ethylene / decylene, and long-chain Alpha-alkene, the catalytic activity is high, the insertion rate of the long-chain Alpha-alkene is high, and molecular weight distribution is wide.

The invention discloses a compound 2-substituent-5-substitued anilino-1,3,4-oxadiazole derivative with functions of resisting plant germs and plant viruses and a preparation method and an application thereof, wherein the structure of the compound is represented by the general formula (I). In the invention, the substituted arylamine is adopted as a start raw material, and a thioether compound is prepared by the steps of esterification, hydrazinolysis, salifying, ring closing and etherification; a sulfone compound is prepared by thioether oxidization. The compound disclosed by the invention has a good inhibiting effect on gibberella zeae, pepper fusarium wilt pathogen, valsa mali and tobacco mosaic virus and can be used for preparing medicines resisting plant germs and plant viruses.

The invention discloses a novel preparation technology of molecule AMD3465 for treating hematopoietic stem cell symptoms. The chemical name of the molecule AMD3465 is 2-pyridine methylamino, N-((3-(1,4,8,11-tetraazacyclotetradecane-methyl)benzyl)methyl-). The novel preparation technology comprises the steps of: with 2-(aminomethyl)pyridine as a raw material, singly butting the 2-(aminomethyl)pyridine with p-Xylylene dibromide, then butting with tricarbonyl torus, and reducing to obtain the product AMD3465 (I), wherein the purity of the product AMD3465 (I) is above 99.5 percent. The novel preparation technology is reasonable in process route and simple and convenient to operation and has broad prospects of popularization and application.