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Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocyclic ring

A technology of ester compounds and methyl pyrimidines, applied in the field of chemistry, can solve the problem of no ideal disease-resistant varieties, and achieve the effects of simple operation, high reaction yield, and easy availability of synthetic raw materials

Active Publication Date: 2018-06-01
GUIZHOU INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no ideal resistant variety against tobacco R. solanacearum, and the development of effective chemical control agents has received the attention of domestic researchers

Method used

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  • Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocyclic ring
  • Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocyclic ring
  • Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocyclic ring

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Compound I 1 Synthesis:

[0041] In a 100mL single-necked bottle, add 2-amino-4-piperidinyl-6-methylpyrimidine (0.001mol), benzaldehyde (0.001mol), diethyl malonate (0.0015mol), add p-xylene ( 30mL) as solvent, microwave at 100°C, finish the reaction after 50 minutes, recover p-xylene under reduced pressure, and separate by column chromatography (petroleum ether:ethyl acetate=4:1V / V) to obtain the target product.

Embodiment 2

[0042] Embodiment 2: Compound I 2 Synthesis:

[0043]In a 100mL single-necked bottle, add 2-amino-4-piperidinyl-6-methylpyrimidine (0.001mol), 4-methoxybenzaldehyde (0.001mol), diethyl malonate (0.0015mol), Add p-xylene (30mL) as a solvent, microwave at 100°C, stop the reaction after 50 minutes, recover p-xylene under reduced pressure, and separate by column chromatography (petroleum ether: ethyl acetate = 4:1 V / V) to obtain the target product.

Embodiment 3

[0044] Embodiment 3: Compound I 3 Synthesis:

[0045] In a 100mL single-necked bottle, add 2-amino-4-piperidinyl-6-methylpyrimidine (0.001mol), 4-chlorobenzaldehyde (0.001mol), diethyl malonate (0.0015mol), and add p Xylene (30 mL) was used as a solvent, and the reaction was terminated after 50 minutes under microwave at 100° C., p-xylene was recovered under reduced pressure, and the target product was obtained through column chromatography (petroleum ether: ethyl acetate = 4:1 V / V).

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Abstract

The invention discloses a preparation method and bioactivity of an amino acid ester compound containing a 4-piperidyl-6-methylpyrimidine heterocyclic ring, which is used for preventing and controllingcucumber mosaic virus, and relates to a compound shown as a general formula (I) and a preparation method thereof. The invention provides the amino acid ester compound containing the 4-piperidyl-6-methylpyrimidine heterocyclic ring, which is synthesized by taking 2-amino-4-piperidyl-6-methylpyrimidine, substituted aldehyde and malonate as raw materials and p-xylene as a solvent through a microwaveone-pot method. The compound I2 provided by the invention has a relatively good inhibition effect on the cucumber mosaic virus and tobacco ralstonia solanacearum. The formula I is shown in the description.

Description

technical field [0001] The invention relates to the field of chemical technology, in particular to an amino acid ester compound containing a 4-piperidinyl-6-methylpyrimidine heterocycle, a preparation method of the compound and a method for treating cucumber mosaic virus disease and tobacco bacterial wilt Inhibitory uses. Background technique [0002] Cucumber Mosaic Virus (CMV) is a member of the brome mosaic virus family and is one of the most widely distributed, most harmful and most economically important viruses. The distribution and hazards of the virus are found in the tobacco and vegetable growing areas around the world. The infection of tobacco and vegetables leads to a decline in yield and quality, or even failure, and brings serious economic losses to agricultural production (Shen Xiaoying, Song Shuang, Luo Jing, Zhang Xin, An Derong. Anti-tobacco cucumber mosaic virus polysaccharide screening and its effect on tobacco defense enzyme activity[J]. Microbiology Jou...

Claims

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Application Information

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IPC IPC(8): C07D239/48C07D405/12A01N43/54A01P1/00
CPCA01N43/54C07D239/48C07D405/12
Inventor 柏松朱芸莹魏娴吴琴邹树良唐芹龚志海周涵周航
Owner GUIZHOU INST OF TECH
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