Method for synthesizing pyrazole compound based on WK (Willgerodt-Kindler) reaction and VHA (Vilsmeier-Haack-Arnold) reaction

Abstract

The invention discloses a method for synthesizing a pyrazole compound based on WK (Willgerodt-Kindler) reaction and VHA (Vilsmeier-Haack-Arnold) reaction. The method comprises the steps that an acyl compound is taken as a raw material to synthesize a carboxylic compound through the WK reaction; a VHA reagent is prepared; the carboxylic compound is added into the VHA reagent to synthesize an oniumsalt condensing agent; the onium salt condensing agent is hydrolyzed to obtain an aldehyde compound; the aldehyde compound is reacted with hydrazine hydrate to obtain the pyrazole compound. The methodhas the advantages that the synthetic route is reasonable, the method is stable and reliable, the synthetic efficiency is high, and the carboxylic compound, the onium salt condensing agent, the aldehyde compound and the pyrazole compound can be obtained simultaneously; the method has wide application prospect and huge commercial value, enriches the variety of inorganic and organic compounds as well as the synthetic method in the inorganic and organic field.

Description

technical field [0001] The invention relates to the synthesis of pyrazole compounds, in particular to a method for synthesizing pyrazole compounds based on Willgerodt-Kindler (WK) reaction and Vilsmeier-Haack-Arnold (VHA) reaction. Background technique [0002] Metal-organic porous materials (MOF) and covalent organic porous materials (COF) are two new types of porous materials that emerged at the end of the 20th century and the beginning of the 21st century. It has good applications in many fields such as transportation and electronic devices. In the design and synthesis process of MOF materials and COF materials, organic ligands are indispensable. There are many designs and choices of organic ligands. Relying on the mature organic synthesis technology, almost any organic ligands you want can be obtained to assemble different MOF materials and COF materials. With the support of strong synthetic chemistry, porous materials also have the ability to change ever-changing. ...

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Problems solved by technology

[0004] At present, there are few reports on pyrazole compounds. Therefore, the research on pyrazole compounds is of great significance for enriching the types of inorganic and organic compounds, as well as the reference of synthetic methods in inorganic and organic fields.

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