The invention provides a modified loofah seed oil-based memory sponge. The modified loofah seed oil-based memory sponge is prepared from the following raw materials in parts by weight: 1-40 parts of loofah seed oil-based polyol, 40-60 parts of first polyether polyol, 10-30 parts of second polyether polyol, 10-20 parts of third polyether polyol, 1-5 parts of water, 5-15 parts of a foaming agent, 0.5-3 parts of a foam stabilizer, 0.3-2 parts of a catalyst, 0.1-0.3 part of an antioxidant and 40-60 parts of modified MDI. The invention also provides a preparation method and application of the modified loofah seed oil-based memory sponge. Meanwhile, the invention further provides the modified loofah seed oil memory sponge pillow. The modified loofah seed oil-based memory sponge material is prepared by mixing loofah seed oil-based polyol with polyether polyol, modified MDI and the like through a polyurethane slow-rebound foaming technology. The sponge is used as a pillow inner material and has the advantages of being antibacterial, capable of helping sleep, breathable, capable of dissipating moisture, good in mechanical performance, low in cost, environmentally friendly and the like.