31results about How to "Promotes re-epithelialization" patented technology

The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue.

The present invention relates to a composition for skin regeneration, using a culture medium or a secretion in the culture of an embryonic stem cell-derived endothelial progenitor cell, and to the use thereof. As the present invention uses the secretion in the culture as a medicine and not the embryonic stem cell-derived endothelial progenitor cell itself, the risk of teratoma formation is prevented, and angiogenic activity is promoted to achieve improved effectiveness in healing wounds and burn wounds. The composition of the present invention, when used as a material in cosmetics, increases collagen synthesis and thus prevents skin aging. Particularly, the composition of the present invention in which the secretion in the culture is concentrated into a high concentration provides superior wound-healing effects as compared to a conventional human growth hormone (hGH).

The invention discloses a skin wound dressing with antibacterial performance and a preparation method thereof, belonging to the technical field of biomedical engineering. The skin wound dressing provided by the present invention has a spongy porous membrane structure. A sodium alginate fiber membrane is prepared by using sodium alginate as a matrix by a freeze-drying method, and then the biological antimicrobial peptide Cys-KR12 is fixed on the fiber membrane by surface modification. Prepared above. The preparation method of the skin wound dressing prepared by the present invention is simple, the source of material is abundant, overcomes the shortcomings such as drug resistance and single function of the existing antibacterial dressing after long-term use, has low immunogenicity, and has good biocompatibility, antibacterial It can promote the healing of wounds and the growth of epithelial cells, which is beneficial to the re-epithelialization of wounds.

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and / or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

The invention relates to the field of biological products, and discloses a collagen-chitosan tissue engineering scaffold compounded with Tβ4, a preparation method thereof and an application in preparation of skin substitutes. The preparation method of the present invention comprises: preparing collagen-chitosan porous scaffold, and soaking collagen-chitosan porous scaffold in Tβ4 solution, obtains the collagen-chitosan porous scaffold of compound Tβ4; Then the collagen-chitosan porous scaffold of compound Tβ4 The chitosan porous scaffolds were subjected to chemical cross-linking treatment and freeze-drying treatment sequentially. The collagen-chitosan tissue engineering scaffold compounded with Tβ4 of the present invention can significantly and effectively promote the regeneration, reconstruction, repair and healing of diabetic and other skin refractory wounds.

The present invention relates to a composite natural sunscreen of Tiannv Mulan and its preparation method. The flavonoids extracted from three plants of Tiannv Mulan, Huai Mi and Scutellaria baicalensis are used as main raw materials, and have obvious broad-spectrum strong ultraviolet absorption effect; The invention mainly utilizes extracts of plant flavonoids such as Magnolias, mink oil that is close to human body fat, and badger oil that has the functions of promoting muscle, skin care, relieving pain, and keeping wounds moist, so as to obtain a new type of plant flavonoids that absorb ultraviolet rays. , Natural sunscreen of animal and vegetable compound oils composed of heat preservation, antifreeze and anti-cracking fatty acids.

The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.

The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.

The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.

The invention provides a preparation method of an antibacterial dressing with slow-release effect and its product. The preparation method comprises: (1) mixing carboxymethyl chitosan, macromolecular collagen, and carboxyl-containing antibiotics; (2) mixing Pour the solution into the mold, let it stand, and dry to obtain an uncrosslinked spongy material; (3) Soak the uncrosslinked spongy material in an absolute ethanol solution containing EDC / NHS, and crosslink at room temperature to obtain an antibacterial dressing. In the present invention, the carboxyl group on the antibiotic is covalently bonded with the amino group on the composite dressing matrix to form an amide bond to realize the grafting of the antibiotic on the dressing matrix, and the slow breaking of the amide bond on the polymer skeleton realizes the slow dissolution of the antibiotic in the dressing. release, thus making antibacterial dressings with high biocompatibility, long-term antibacterial activity, and promoting wound healing.

The invention provides a preparation method of stem cell ointment and the ointment prepared by the method. In the present invention, mesenchymal stem cells with immune regulation and tissue regeneration functions are prepared into agglomerates of uniform size under 3D suspension culture conditions, and mixed in a non-biotoxic active energy matrix to prepare an ointment. Stem cells can survive in this ointment at room temperature for up to a week, maintaining biological activity. The stem cell ointment provided by the invention can be directly applied to the damaged skin, and the stem cells therein will migrate into the wound to suppress inflammation and promote tissue regeneration, accelerate wound healing and significantly improve the healing condition, and reduce scar formation. After the repair process is completed, the stem cells will be cleared by the autoimmune system without residue, safe, stable and efficient.