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Re-epithelializing pharmaceutical compositions comprising xanthan gum

a technology of xanthan gum and composition, which is applied in the direction of drug compositions, aerosol delivery, inorganic non-active ingredients, etc., can solve the problems of long wound healing period, imperfect wound closure, and many discomfort, and achieve the effect of accelerating re-epithelialization and being well tolerated

Inactive Publication Date: 2008-06-19
S I F I SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004]The object of the present invention is a pharmaceutical composition that can accelerate re-epithelialization, especially of the corneal tissue, and is also well tolerated.

Problems solved by technology

Injuries of this sort generally require long wound healing periods; cause much discomfort and often an imperfect wound closure.

Method used

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Examples

Experimental program
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Embodiment Construction

[0007]A surprising experimental finding was the observation that xanthan gum shows a high re-epithelializing function, that is to say, it is able to accelerate the formation of new epithelial cells at the level of the damaged epithelial zone, as shown also in an in vivo experiment reported later in the present description.

[0008]Xanthan gum is a heteropolysaccharide with a molecular weight between 3−7.5×10 Da, produced through a process of fermentation by the bacterium Xanthomonas campestris.

[0009]The primary structure of xanthan is a branched chain, with a main chain of β(1→4)-D-glucose identical to cellulose wherein, a trisaccharide chain with a glucosidic link β(1♯3), composed of acetylated mannose, glucuronic acid, and mannose is linked to every other second residue; finally, to each carbon C4 and C6 of the terminal unit of mannose a molecule of pyruvic acid is linked in a variable proportion of 25-50%, that completes the structure of the lateral chain of the polymer.

[0010]The a...

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PUM

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Abstract

The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.

Description

RELATED APPLICATIONS[0001]This application is a divisional of application Ser. No. 10 / 512,521 filed Oct. 25, 2004, which is a National Stage under 35 U.S.C. § 371 of PCT / IT03 / 00257, filed on Apr. 24, 2003 claiming priority under Section 119(e) to application number EPO 02425274.4 filed Apr. 30, 2002, the contents of which are hereby incorporated by referenceFIELD OF THE INVENTION[0002]The present invention relates to re-epithelializing pharmaceutical compositions especially for ophthalmic use.BACKGROUND ART[0003]It is well known that epithelial cells, for example in the cornea, may suffer injuries caused by foreign bodies, such as abrasions, cuts and wounds (accidental, surgical, immunological etc), and postinfective ulcers. Injuries of this sort generally require long wound healing periods; cause much discomfort and often an imperfect wound closure.SUMMARY OF THE INVENTION[0004]The object of the present invention is a pharmaceutical composition that can accelerate re-epithelializat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/573A61P43/00A61K9/00C07H15/236A61K9/06A61K31/7032A61K31/715A61K31/723A61K31/728A61K45/00A61K47/02A61K47/10A61K47/12A61K47/16A61K47/20A61K47/24A61K47/36A61P17/00A61P17/02A61P25/04A61P27/02A61P29/00A61P31/00C07J5/00C08B37/00C08B37/08
CPCA61K9/0048A61K9/06A61K31/573A61K31/715A61K31/723A61K47/36A61K2300/00A61P17/00A61P17/02A61P25/04A61P27/02A61P29/00A61P31/00A61P43/00A61K31/661A61K31/7036A61K31/728
Inventor MAZZONE, MARIA GRAZIAPALADINO, GRAZIAMARINO, CLARAPERI, ORNELLAENEA, VINCENZO
Owner S I F I SPA
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