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A kind of preparation method and product thereof with sustained-release antibacterial dressing

A function and slow-release technology, applied in bandages, absorbent pads, medical science, etc., can solve problems such as organ damage, achieve good re-epithelialization, prevent adverse effects, and good water absorption

Active Publication Date: 2021-04-27
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the toxicity of these nanomaterials cannot be ignored. Studies have shown that nanosilver has obvious damage to various organs such as the spleen, liver and kidneys.

Method used

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  • A kind of preparation method and product thereof with sustained-release antibacterial dressing
  • A kind of preparation method and product thereof with sustained-release antibacterial dressing
  • A kind of preparation method and product thereof with sustained-release antibacterial dressing

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Embodiment

[0029] A preparation method of an antibacterial dressing with sustained release, comprising the following steps:

[0030] (1) Dissolve carboxymethyl chitosan, macromolecular collagen, and carboxyl-containing antibiotics in deionized water, and stir evenly to obtain a mixed solution. The mass ratio of carboxymethyl chitosan to macromolecular collagen in the mixed solution is 0.75~2.5: 1, the concentration of carboxyl-containing antibiotics is 0.5~1 mmol / L;

[0031] (2) Pour the mixed liquid obtained in step (1) into the mold, let it stand for defoaming, freeze-dry, and obtain an uncrosslinked spongy material after drying;

[0032] (3) Soak the uncrosslinked spongy material obtained in step (2) in an absolute ethanol solution containing EDC / NHS, and the amount of EDC is based on the excess molar amount of EDC relative to the total molar amount of carboxyl groups in the mixed solution. Standard, the molar ratio of EDC to NHS is 4:1, cross-linking reaction at room temperature for...

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Abstract

The invention provides a preparation method of an antibacterial dressing with slow-release effect and its product. The preparation method comprises: (1) mixing carboxymethyl chitosan, macromolecular collagen, and carboxyl-containing antibiotics; (2) mixing Pour the solution into the mold, let it stand, and dry to obtain an uncrosslinked spongy material; (3) Soak the uncrosslinked spongy material in an absolute ethanol solution containing EDC / NHS, and crosslink at room temperature to obtain an antibacterial dressing. In the present invention, the carboxyl group on the antibiotic is covalently bonded with the amino group on the composite dressing matrix to form an amide bond to realize the grafting of the antibiotic on the dressing matrix, and the slow breaking of the amide bond on the polymer skeleton realizes the slow dissolution of the antibiotic in the dressing. release, thus making antibacterial dressings with high biocompatibility, long-term antibacterial activity, and promoting wound healing.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a preparation method of an antibacterial dressing with slow-release effect and its product. Background technique [0002] In order to avoid wound infection, wound dressings should have good antibacterial activity. An ideal antimicrobial dressing would effectively kill bacteria or fungi in wound infections, prevent bacterial biofilm formation, and prevent wound reinfection during healing, wound inspection, surgery, or dressing changes. However, the current commonly used antibacterial dressing preparation method is to physically mix small molecule drugs in the material (for example, the Chinese patent with the authorized announcement number CN201337582 discloses a method of adding ciprofloxacin to chitosan glue by physical mixing. method for preparing chitosan antiseptic dressings), which provides a viable option for the treatment of wound infections. However, because the antibacterial drugs o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/46A61L15/28A61L15/32
CPCA61L15/28A61L15/325A61L15/42A61L15/425A61L15/46A61L2300/406A61L2300/412A61L2300/602C08L5/08
Inventor 杨建民石贤爱胡圣学
Owner FUZHOU UNIV
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