The invention discloses a method for preparing a multilayer composite structure material of a NiFeBMo-based opening and closing locker. Using NiFeBMo matrix alloy, anti-wear agent, heat conduction agent, reinforcing agent and curing agent as raw materials, the raw material powder of each layer is passed through each layer Structural design and composition calculation, proportioning preparation, vibration mixing, dry hot pressing, curing heat treatment, superimposed sintering and each layer of machining process are made of NiFeBMo-based multilayer composite structure material for opening and closing locker, which has various The layer has the advantages of different composition, different thickness, and large component difference, and presents a gradient distribution trend, which not only saves the relative amount of materials, but also significantly enhances its friction and wear properties. At the same time, the preparation method of the present invention is simple, the preparation process is easy to control, the efficiency is high, the process parameters are stable, the operation is easy to control, and the structure of each layer of the obtained opening and closing locker can be freely divided and repaired, the mechanical performance is stable, and the service life is long.