The present invention provides a multi-screen display system and a multi-screen display setting method. The multi-screen display system includes a computer host and multiple displays, the computer host is provided with an acquisition module, used for acquiring mouse movement path; a monitor module, used for monitoring acquired mouse movement path, when failure of the mouse crossing the display boundary or the unconformity of the entering display with the prospect is monitored, touching an adjustment module; a adjustment module, used for adjusting the multiple-screen display according to the touch of the monitor module, ensuring the display entered by the mouse match with the prospect. The technical solution of the invention automatically processes multiple-screen display set according to the moving track of the mouse, when processing the multiple-screen set, need not remember the number and relative position of each display, having simple operation, need not increase new hardware consumption, having lower cost.