The invention belongs to the technical field of marine antifouling materials, and discloses main chain degradable zinc polyacrylate resin prepared by the aid of monomer processes and a method and application of the main chain degradable zinc polyacrylate resin. The main chain degradable zinc polyacrylate resin is mainly prepared from components including, by weight, 5-80 parts of vinyl zinc ester functional monomers, 5-95 parts of cyclic monomers, 0-95 parts of vinyl monomers, 0.01-10 parts of initiators and 50-100 parts of organic solvents. The main chain degradable zinc polyacrylate resin, the method and the application have the advantages that zinc ester bonds of side chains and polyester chain segments of main chains of the main chain degradable zinc polyacrylate resin can be hydrolyzed under the attack effect of seawater, accordingly, the problem of dependence of the traditional self-polish materials on navigational speeds can be solved, the surfaces of coatings can be regenerated in static seawater under hydrolytic degradation effects, antifouling agents can be released at constant speeds under effective control, and antifouling requirements of ships at low navigational speeds and facilities such as offshore oil production platforms can be met; the main chain degradable zinc polyacrylate resin is excellent in drag reduction performance; the main chain degradable zinc polyacrylate resin is used for marine antifouling coating.